ID A0A2Y9PKM3_DELLE Unreviewed; 1556 AA.
AC A0A2Y9PKM3;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=CLIP-associating protein 1 isoform X7 {ECO:0000313|RefSeq:XP_022446310.1};
GN Name=CLASP1 {ECO:0000313|RefSeq:XP_022446310.1};
OS Delphinapterus leucas (Beluga whale).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Monodontidae; Delphinapterus.
OX NCBI_TaxID=9749 {ECO:0000313|Proteomes:UP000248483, ECO:0000313|RefSeq:XP_022446310.1};
RN [1] {ECO:0000313|RefSeq:XP_022446310.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022446310.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Chromosome, centromere, kinetochore
CC {ECO:0000256|ARBA:ARBA00004629}. Cytoplasm, cytoskeleton, microtubule
CC organizing center, centrosome {ECO:0000256|ARBA:ARBA00004300}. Golgi
CC apparatus, trans-Golgi network {ECO:0000256|ARBA:ARBA00004601}.
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DR RefSeq; XP_022446310.1; XM_022590602.2.
DR Proteomes; UP000248483; Unplaced.
DR GO; GO:0005813; C:centrosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR GO; GO:0000776; C:kinetochore; IEA:UniProtKB-KW.
DR GO; GO:0008017; F:microtubule binding; IEA:UniProt.
DR GO; GO:0051494; P:negative regulation of cytoskeleton organization; IEA:UniProt.
DR GO; GO:1902904; P:negative regulation of supramolecular fiber organization; IEA:UniProt.
DR GO; GO:0031110; P:regulation of microtubule polymerization or depolymerization; IEA:UniProt.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 4.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR024395; CLASP_N_dom.
DR InterPro; IPR021133; HEAT_type_2.
DR InterPro; IPR034085; TOG.
DR InterPro; IPR048491; XMAP215_CLASP_TOG.
DR PANTHER; PTHR21567; CLASP; 1.
DR PANTHER; PTHR21567:SF28; CLIP-ASSOCIATING PROTEIN 1; 1.
DR Pfam; PF21040; CEP104-like_TOG; 1.
DR Pfam; PF12348; CLASP_N; 1.
DR Pfam; PF21041; XMAP215_CLASP_TOG; 1.
DR SMART; SM01349; TOG; 4.
DR SUPFAM; SSF48371; ARM repeat; 2.
DR PROSITE; PS50077; HEAT_REPEAT; 1.
PE 4: Predicted;
KW Centromere {ECO:0000256|ARBA:ARBA00023328};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Kinetochore {ECO:0000256|ARBA:ARBA00022838};
KW Reference proteome {ECO:0000313|Proteomes:UP000248483};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 1..232
FT /note="TOG"
FT /evidence="ECO:0000259|SMART:SM01349"
FT REPEAT 168..206
FT /note="HEAT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT DOMAIN 319..551
FT /note="TOG"
FT /evidence="ECO:0000259|SMART:SM01349"
FT DOMAIN 866..1104
FT /note="TOG"
FT /evidence="ECO:0000259|SMART:SM01349"
FT DOMAIN 1307..1545
FT /note="TOG"
FT /evidence="ECO:0000259|SMART:SM01349"
FT REGION 235..291
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 543..790
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1097..1137
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1152..1176
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1221..1287
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1326..1353
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 250..267
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 543..605
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 651..702
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 716..764
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1556 AA; 170913 MW; 8C7857B013731CF9 CRC64;
MEPRMEACLA QVLQKDVGKR LQVGQELIDY FSDKQKSADL EHDQTTLDKL VDGLATFWVN
SSNYKVVLLG MDILSSLVTR LQDRFKAQIG TVLPSLIDRL GDAKDSVREQ DQALLLKIMD
QAANPQYVWD RMLGGFKHKN FRTREGTCLC LVATLNASGA HTLTLSKIVP HICNLLGDPN
SQVRDAAINS LVEIYRHVGE RVRADLSKKG LPQSRLNVIF TKFDEVQKSG NMIQSANDKN
FDDEDSVDGN RPSSASSTSS KAPASSRRNV GMGTARRLGS STLGSKSSAA KEGAGAVDEE
DFIKAFDDVP VVQIYSSRDL EESINKIREI LSDDKHDWEQ RVTALKKIRS LLLAGAAEYD
NFFQHLRLLD GAFKLSAKDL RSQVVREACI TLGHLSSVLG NKFDHGAEAI MPTIFNLIPN
SAKIMATSGV VAVRLIIRHT HIPRLIPIIT SNCTSKSVAV RRRCFEFLDL LLQEWQTHSL
ERHISVLAET IKKGIHDADS EARIEARKCY WGFHSHFSRE AEHLYHTLEP SYQRALQSHL
KSSDSVVSLP QSDRSSSSSQ ESLNRPLSAK RSPTGSATSR ASTVSSKSVS TTGSLQRSRS
DIDVNAAASA KSKVPSAPGA APFSSAAALP PGSYASLDGT ATKAEGRIRT RRQSSGSATN
VTSTPSDSRG RSRAKVVSQS QRSRSANPAG AGSRSSSPGK LLGSGYSGLA GGSSRGPPAT
PSSEKRSKIP RSQGCSRETS PNRIGLARSS RIPRPSMSQG CSRDASRESS RDTSPARGFP
PLDRFGLGQA GRIPGSVNAM RVLSTSADLE AAVADALLLG DSRSKKKPVR RRYEPYGMYS
DDDANSDASS VCSERSYSSR NGGIPHYLRQ TEDVAEVLNH CASSNWSERK EGLLGLQNLL
KSQRTLSRVE LKRLCEIFTR MFADPHSKRV FSMFLETLVD FIIIHKDDLQ DWLFVLLTQL
LKKMGADLLG SVQAKVQKAL DVTRDSFPFD QQFNILMRFI VDQTQTPNLK VKVAILKYIE
SLARQMDPTD FINSSETRLA VSRIITWTTE PKSSDVRKAA QIVLISLFEL NTPEFTMLLG
ALPKTFQDGA TKLLHNHLKN SSNTSVGSPS NTIGRTPSRH PSSRTSPLTS PTNCSHGGLS
PSRLWGCSAD GWSKQPAPFP QPSSIPTAPS HKTLRRPYSP SLLDYDTENL NSEEIYSSLR
GVTEAIEKFS FRSQEDLNEP IKRDGRKDCD VVSRDGGITS PATEGRGGSD AVEGGRTALD
NKTSLLNTQP PRAFPGPRAR DYSPYPYSDT ISTYDKTALK EAVFDDDMEQ LRDVPIDHSD
LVADLLKELS NHNERVEERK GALLELLKIA REDSLGVWEE HFKTVLLLLL ETLGDKDHSI
RALALRVLRE TLRSQPARFK HYAELTIMKT LEAHKDSHKE VVRAAEEAAS TLASSIHPEQ
CIKVLCPIIQ TADYPINLAA IKMQTKVVER IAKEALLQLL ADIIPGLLQG YDNTESSVRK
ASVFCLVAIY SVIGEELKPH LAQLTGSKMK LLNLYIKRAQ TTNSNSSSSS DVSTHS
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