ID   A0A2Y9PLU0_DELLE        Unreviewed;       651 AA.
AC   A0A2Y9PLU0;
DT   12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT   12-SEP-2018, sequence version 1.
DT   27-MAR-2024, entry version 26.
DE   RecName: Full=Amiloride-sensitive sodium channel subunit gamma {ECO:0000256|ARBA:ARBA00039160};
DE   AltName: Full=Epithelial Na(+) channel subunit gamma {ECO:0000256|ARBA:ARBA00041623};
DE   AltName: Full=Gamma-NaCH {ECO:0000256|ARBA:ARBA00042229};
DE   AltName: Full=Nonvoltage-gated sodium channel 1 subunit gamma {ECO:0000256|ARBA:ARBA00043111};
DE   AltName: Full=SCNEG {ECO:0000256|ARBA:ARBA00041935};
GN   Name=SCNN1G {ECO:0000313|RefSeq:XP_022444262.1};
OS   Delphinapterus leucas (Beluga whale).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC   Monodontidae; Delphinapterus.
OX   NCBI_TaxID=9749 {ECO:0000313|Proteomes:UP000248483, ECO:0000313|RefSeq:XP_022444262.1};
RN   [1] {ECO:0000313|RefSeq:XP_022444262.1}
RP   IDENTIFICATION.
RC   TISSUE=Blood {ECO:0000313|RefSeq:XP_022444262.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Apical cell membrane
CC       {ECO:0000256|ARBA:ARBA00004424}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004424}. Cell membrane
CC       {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the amiloride-sensitive sodium channel (TC
CC       1.A.6) family. SCNN1G subfamily. {ECO:0000256|ARBA:ARBA00038067}.
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DR   RefSeq; XP_022444262.1; XM_022588554.2.
DR   AlphaFoldDB; A0A2Y9PLU0; -.
DR   STRING; 9749.A0A2Y9PLU0; -.
DR   Ensembl; ENSDLET00000013578; ENSDLEP00000012302; ENSDLEG00000008999.
DR   KEGG; dle:111182247; -.
DR   InParanoid; A0A2Y9PLU0; -.
DR   OrthoDB; 5344287at2759; -.
DR   Proteomes; UP000248483; Unplaced.
DR   GO; GO:0016324; C:apical plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015280; F:ligand-gated sodium channel activity; IEA:InterPro.
DR   GO; GO:0050896; P:response to stimulus; IEA:UniProtKB-KW.
DR   GO; GO:0050909; P:sensory perception of taste; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.470.10; Acid-sensing ion channels like domains; 1.
DR   Gene3D; 1.10.287.770; YojJ-like; 1.
DR   InterPro; IPR001873; ENaC.
DR   InterPro; IPR004724; ENaC_chordates.
DR   InterPro; IPR020903; ENaC_CS.
DR   NCBIfam; TIGR00859; ENaC; 1.
DR   PANTHER; PTHR11690:SF19; AMILORIDE-SENSITIVE SODIUM CHANNEL SUBUNIT GAMMA; 1.
DR   PANTHER; PTHR11690; AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED; 1.
DR   Pfam; PF00858; ASC; 1.
DR   PRINTS; PR01078; AMINACHANNEL.
DR   PROSITE; PS01206; ASC; 1.
PE   3: Inferred from homology;
KW   Ion channel {ECO:0000313|RefSeq:XP_022444262.1};
KW   Ion transport {ECO:0000256|ARBA:ARBA00022461};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000248483};
KW   Sensory transduction {ECO:0000256|ARBA:ARBA00022606};
KW   Sodium {ECO:0000256|ARBA:ARBA00023053};
KW   Sodium channel {ECO:0000256|ARBA:ARBA00022461};
KW   Sodium transport {ECO:0000256|ARBA:ARBA00023201};
KW   Taste {ECO:0000256|ARBA:ARBA00022480};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022461}.
FT   TRANSMEM        54..79
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   REGION          579..599
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   651 AA;  74044 MW;  F17438996293D961 CRC64;
     MAAGEKIKAK IKKNLPVRGP QAPTIKELMR WYCLNTNTHG CRRIVVSRGR LRRLLWILFT
     LTAVALIFWQ CALLISSFYT VSVSIKVHFQ KLDFPAVTIC NINPYRYSAV RDLLAELEQE
     TRGSLKTLFG FSEITSRKRR EAESWSSARK GTGSKFLNLI PLLAFDKGET SKARDFRTGR
     KRKVSGRIIH TASDVVHVYE SKGLVGFQLC SNDTSSCAVY TFTSGVNAIR EWYKLHYMNI
     MAQVSLEKKI NMSYSAEELL VTCFFDGESC DARNFTRFHH PMYGNCYTFN NRQNETILST
     SMGGSEYGLQ VILYLNEEEY NPFLVSSTGA KVIVHRQYEY PFIEDVGTEI ETAMATSIGM
     HLTESFKLSE PYSRCTEDWN GVLITNIYNA TYSLQICLHS CFQAKMVEKC GCAQFSQPLP
     QGANYCNYRQ HPNWMYCYYE LHQAFVWGEL GCQSVCKEAC SFKEWTLTTS LAQWPSEVSE
     KWLLSVLTWD QGQIKKKLNK TDLAKLLIFY KDLNQRSIVE SPANSIEMLL SNIGGQLGLW
     MSCSIVCIIE IIEVFFIDSL SIVARHQWHK AKEWWARRQA SPCPEAPPSP QGQDNLGLNM
     DDDLPTFTSA LCLPPAPAAQ VPGTPPPRYN TLRLERTFSR QLTGTEVPAE S
//