ID A0A2Y9PMP4_DELLE Unreviewed; 1068 AA.
AC A0A2Y9PMP4;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=Retinoblastoma-like protein 1 isoform X1 {ECO:0000313|RefSeq:XP_022448174.1};
GN Name=RBL1 {ECO:0000313|RefSeq:XP_022448174.1};
OS Delphinapterus leucas (Beluga whale).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Monodontidae; Delphinapterus.
OX NCBI_TaxID=9749 {ECO:0000313|Proteomes:UP000248483, ECO:0000313|RefSeq:XP_022448174.1};
RN [1] {ECO:0000313|RefSeq:XP_022448174.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022448174.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the retinoblastoma protein (RB) family.
CC {ECO:0000256|ARBA:ARBA00009475}.
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DR RefSeq; XP_022448174.1; XM_022592466.2.
DR AlphaFoldDB; A0A2Y9PMP4; -.
DR Ensembl; ENSDLET00000020329; ENSDLEP00000018434; ENSDLEG00000013443.
DR KEGG; dle:111184203; -.
DR Proteomes; UP000248483; Unplaced.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0005667; C:transcription regulator complex; IEA:Ensembl.
DR GO; GO:1990841; F:promoter-specific chromatin binding; IEA:Ensembl.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR GO; GO:2000773; P:negative regulation of cellular senescence; IEA:Ensembl.
DR GO; GO:0010629; P:negative regulation of gene expression; IEA:Ensembl.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:0051726; P:regulation of cell cycle; IEA:InterPro.
DR CDD; cd20605; CYCLIN_RBL1; 1.
DR Gene3D; 1.10.472.140; -; 1.
DR Gene3D; 1.10.472.10; Cyclin-like; 3.
DR InterPro; IPR013763; Cyclin-like_dom.
DR InterPro; IPR036915; Cyclin-like_sf.
DR InterPro; IPR002720; RB_A.
DR InterPro; IPR002719; RB_B.
DR InterPro; IPR015030; RB_C.
DR InterPro; IPR028309; RB_fam.
DR InterPro; IPR024599; RB_N.
DR PANTHER; PTHR13742; RETINOBLASTOMA-ASSOCIATED PROTEIN RB -RELATED; 1.
DR PANTHER; PTHR13742:SF20; RETINOBLASTOMA-LIKE PROTEIN 1; 1.
DR Pfam; PF11934; DUF3452; 1.
DR Pfam; PF01858; RB_A; 1.
DR Pfam; PF01857; RB_B; 1.
DR Pfam; PF08934; Rb_C; 1.
DR SMART; SM00385; CYCLIN; 1.
DR SMART; SM01367; DUF3452; 1.
DR SMART; SM01368; RB_A; 1.
DR SMART; SM01369; Rb_C; 1.
DR SUPFAM; SSF47954; Cyclin-like; 2.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW Chromatin regulator {ECO:0000256|ARBA:ARBA00022853};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000248483};
KW Repressor {ECO:0000256|ARBA:ARBA00022491};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 70..212
FT /note="Retinoblastoma-associated protein N-terminal"
FT /evidence="ECO:0000259|SMART:SM01367"
FT DOMAIN 385..578
FT /note="Retinoblastoma-associated protein A-box"
FT /evidence="ECO:0000259|SMART:SM01368"
FT DOMAIN 801..899
FT /note="Cyclin-like"
FT /evidence="ECO:0000259|SMART:SM00385"
FT DOMAIN 952..1068
FT /note="Retinoblastoma-associated protein C-terminal"
FT /evidence="ECO:0000259|SMART:SM01369"
SQ SEQUENCE 1068 AA; 120617 MW; 101CA38323BDFB66 CRC64;
MDEDDPHSEG AAVVAAAGEA LQALCQELNL DEGSAAEALD DFTAIRGNYS LEGEVIHWLA
CSLYVACRKS IIPTVGKGIM EGNCVSLTRI LRSAKLSLIQ FFSKMKKWMD MSNLPQEFRE
RIERLERNFE VSTVIFKKFE PIFLDIFQNP YEEPPKLPRS RKQRRIPCSV KELFNFCWTL
FVYTKGNFRM IGDDLVNSYH LLLCCLDLIF ANAIMCPNRR DLLNPSFKGL PSDFHTADFR
ASEEPPCIIP VLCELHDGLL VEAKGIKEHY FKPYISKLFD RKILKGECLL DLSSFTDNSK
AVNKEYEEYV LTVGDFDERI FLGADAEEEI GTPRKFTGDA PLGKLTAQAN VECNLQQHFE
KKTSFAPSTP LTGRRYLREK EAVITPVASA TQSVSRLQSI VAGLKNAPSE QLINIFGSCM
RNPMENIMKT VKLIGQTFCQ HYTQSTDEQP GSHIDFAVNR LKLAEILYYK ILETVMVQET
RRLHGMDMSV LLEQDIFHHS LMACCLEIVL FAYSSPRTFP WIIQVLNLRP FYFYKVIEVV
IRSEEGLSRD MVKHLNSIEE QILESLAWSH DSALWEALQA STNRVPTCEE VIFPNNFETG
NGGNVQGHLP MMPMSPLMHP RVKEVRTDSG SLRKDTQPLS PISVHERYSS PTAGSAKRRL
FGEDPPKEML MDRIITEGTK LKIAPSSSIT AENISISPGQ SLLTMATAIV TGTTGHKVTI
PLHGIANDAG EITLIPISMN TTQESQVESP VSLTAQSLIG ASPKQTHLTK AQEVHSVGIS
KPKRTGSLAL FYRKVYHLAS VRLRDLCLKL DVSNELRRKI WTCFEFTLVH CPDLMKDRHL
DQLLLCAFYI MAKVTKEERT FQEIMKSYRN QPQANSHVYR SVLLKSIPRE VVTYNKNLNG
DFEMTDCDLE DATKTPDCSS GPVKEERGDL IKFYNTIYVG RVKSFALKYD LSNQDHVMEA
PPLSPFPHIK QQPGSPRRIS QQHSIYVSPH KNGSGLTPRS ALLYKFNGSP SKSLKDINNM
IRQGEQRTKK RAIAIDGDAE SPAKRLCQEN DDILLKRLQD VVSERANH
//
