ID A0A2Y9PMR5_DELLE Unreviewed; 625 AA.
AC A0A2Y9PMR5;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Polycystic kidney disease 2-like 2 protein isoform X1 {ECO:0000313|RefSeq:XP_022444587.1};
GN Name=PKD2L2 {ECO:0000313|RefSeq:XP_022444587.1};
OS Delphinapterus leucas (Beluga whale).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Monodontidae; Delphinapterus.
OX NCBI_TaxID=9749 {ECO:0000313|Proteomes:UP000248483, ECO:0000313|RefSeq:XP_022444587.1};
RN [1] {ECO:0000313|RefSeq:XP_022444587.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022444587.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell projection, cilium membrane
CC {ECO:0000256|ARBA:ARBA00004272}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004272}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the polycystin family.
CC {ECO:0000256|ARBA:ARBA00007200}.
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DR RefSeq; XP_022444587.1; XM_022588879.2.
DR AlphaFoldDB; A0A2Y9PMR5; -.
DR STRING; 9749.A0A2Y9PMR5; -.
DR KEGG; dle:111182484; -.
DR Proteomes; UP000248483; Unplaced.
DR GO; GO:0060170; C:ciliary membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR CDD; cd22265; UDM1_RNF168; 1.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 1.
DR InterPro; IPR013122; PKD1_2_channel.
DR InterPro; IPR003915; PKD_2.
DR InterPro; IPR046791; Polycystin_dom.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR10877:SF47; POLYCYSTIC KIDNEY DISEASE 2-LIKE 2 PROTEIN; 1.
DR PANTHER; PTHR10877; POLYCYSTIN FAMILY MEMBER; 1.
DR Pfam; PF08016; PKD_channel; 1.
DR Pfam; PF20519; Polycystin_dom; 1.
DR PRINTS; PR01433; POLYCYSTIN2.
PE 3: Inferred from homology;
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000248483};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 32..51
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 230..252
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 277..297
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 318..346
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 366..387
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 407..429
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 469..490
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 77..272
FT /note="Polycystin"
FT /evidence="ECO:0000259|Pfam:PF20519"
FT DOMAIN 273..497
FT /note="Polycystin cation channel PKD1/PKD2"
FT /evidence="ECO:0000259|Pfam:PF08016"
FT REGION 531..557
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 141..154
FT /evidence="ECO:0000256|PIRSR:PIRSR603915-2"
SQ SEQUENCE 625 AA; 74351 MW; 0388A94778FAD644 CRC64;
MAEASRWHLG GTPKHKLHYR KEVEMRTTLQ EFLLYLIFLI NLCILTFGMV NPHMYYLNKV
MSSLFLDTSV HGEERINFKS IRSITDFWKF MEGPLLEGLY WDSWYNNKNL YDLKNSSRIY
YENILLGVPR VRQLKVRNNT CKVHSSFRSL MNECYDKYTS ENEDLSDFGL KYDTEWKYSA
PIINSPWHWG FTGVYRNGGY IFTLPKSKSE TLNKFINLRM NSWITRSTRV IFIDFSLYNA
NVNLFCIIRL VAEFPATGGI LTSWQFYSVK LLRYVSYYDY FIASCEITFC IFLIVFTTQE
VLKIKEFKSA YFKSSWNWLE LLLLVLCFVA VFFNSYCNIQ TFLLLGQLLK STEKYSDFYF
LAHWHIYYNN IIAITIFFAW IKIFKFISFN KTMSQLSSTL SRCIKDIVGF AIMFFIIFFA
YAQLGFLVFG SQVDDFSTFQ NSIFTQFRIV LGDFNFAGIQ QASRILGPIY FITFIFFVFF
VLLNMFLAII NDTYSEVKAD YSIGRRPDFE LGKMIKKSYH NALEKLKLKK PETDEDKKRK
SRDLAEQARR EGFDEKEIQS AEQMKKWKER LEKKYYSTEI QDDYQPVTQQ EFRDLFLYAV
ELEKELHYVS LKLNRVMRKV SALQY
//
