ID A0A2Y9PNE3_DELLE Unreviewed; 609 AA.
AC A0A2Y9PNE3;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Mitochondrial import receptor subunit TOM70 isoform X1 {ECO:0000313|RefSeq:XP_022444288.1};
GN Name=TOMM70 {ECO:0000313|RefSeq:XP_022444288.1};
OS Delphinapterus leucas (Beluga whale).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Monodontidae; Delphinapterus.
OX NCBI_TaxID=9749 {ECO:0000313|Proteomes:UP000248483, ECO:0000313|RefSeq:XP_022444288.1};
RN [1] {ECO:0000313|RefSeq:XP_022444288.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022444288.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004167}. Mitochondrion
CC outer membrane {ECO:0000256|ARBA:ARBA00004572}; Single-pass membrane
CC protein {ECO:0000256|ARBA:ARBA00004572}.
CC -!- SIMILARITY: Belongs to the Tom70 family.
CC {ECO:0000256|ARBA:ARBA00038030}.
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DR RefSeq; XP_022444288.1; XM_022588580.2.
DR AlphaFoldDB; A0A2Y9PNE3; -.
DR STRING; 9749.A0A2Y9PNE3; -.
DR Ensembl; ENSDLET00000019036; ENSDLEP00000017261; ENSDLEG00000012606.
DR KEGG; dle:111182242; -.
DR InParanoid; A0A2Y9PNE3; -.
DR OrthoDB; 1083789at2759; -.
DR Proteomes; UP000248483; Unplaced.
DR GO; GO:0005741; C:mitochondrial outer membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0060090; F:molecular adaptor activity; IEA:Ensembl.
DR GO; GO:0002218; P:activation of innate immune response; IEA:Ensembl.
DR GO; GO:0098586; P:cellular response to virus; IEA:Ensembl.
DR GO; GO:0002230; P:positive regulation of defense response to virus by host; IEA:Ensembl.
DR GO; GO:0032728; P:positive regulation of interferon-beta production; IEA:Ensembl.
DR GO; GO:0042981; P:regulation of apoptotic process; IEA:Ensembl.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 2.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR001440; TPR_1.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR46208; MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM70; 1.
DR PANTHER; PTHR46208:SF1; MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM70; 1.
DR Pfam; PF00515; TPR_1; 1.
DR Pfam; PF13181; TPR_8; 4.
DR SMART; SM00028; TPR; 10.
DR SUPFAM; SSF48439; Protein prenylyltransferase; 1.
DR SUPFAM; SSF48452; TPR-like; 1.
DR PROSITE; PS50005; TPR; 5.
DR PROSITE; PS50293; TPR_REGION; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Mitochondrion outer membrane {ECO:0000256|ARBA:ARBA00022787};
KW Receptor {ECO:0000313|RefSeq:XP_022444288.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000248483};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW TPR repeat {ECO:0000256|ARBA:ARBA00022803, ECO:0000256|PROSITE-
KW ProRule:PRU00339}; Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT REPEAT 115..148
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 368..401
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 402..435
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 477..510
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 546..579
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REGION 64..108
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 64..87
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 609 AA; 67545 MW; 426D05AC1BD38211 CRC64;
MAASKPVEAA VVAAAIPGSG SGVGGGSATA GPGTGGLPRW QLALAVGAPL LLGAGAMYLW
SRQRRRRETG GRGDASGLKR NSERKTPEGR ASPAPGSGHP EGPGTHLEMN SLDRAQAAKN
KGNKYFKAGK YEQAIQCYTE AISLCPTEKN VDLSTFYQNR AAAFEQLQKW KEVAQDCTKA
VELNPKYVKA LFRRAKAHEK LDNKKECLED VTAVCILEGF QNQQSMLLAD KVLKLLGKEK
AKEKYKNREP LMPSPQFIKS YFSSFTDDII SQPMLKGEKS DEDKDKEGEA LEVKENSGYL
KAKQYMEEEN YDKIISECSK EVDAQGKYMA EALLLRATFY LLIGNANAAK PDLDKVISLK
EANVKLRANA LIKRGSMYMQ QQQPLLSTQD FNMAADIDPQ NADVYHHRGQ LKILLDQVEE
AVADFDECIR LRPESALAQA QKCFALYRQA YTGNNSSQIQ AAMKGFEEVI KKFPRCAEGY
ALYAQALTDQ QQFGKADEMY DKCINLEPDN ATTYVHKGLL QLQWKQDLDR GLELISKAIE
IDNKCDFAYE TMGTIEVQRG NMEKAIDMFN KAINLAKSEM EMAHLYSLCD AAHAQTEVAK
KYGLKPPTL
//
