ID A0A2Y9PPC3_DELLE Unreviewed; 1028 AA.
AC A0A2Y9PPC3;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Neuronal cell adhesion molecule isoform X4 {ECO:0000313|RefSeq:XP_022448719.1};
GN Name=NRCAM {ECO:0000313|RefSeq:XP_022448719.1};
OS Delphinapterus leucas (Beluga whale).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Monodontidae; Delphinapterus.
OX NCBI_TaxID=9749 {ECO:0000313|Proteomes:UP000248483, ECO:0000313|RefSeq:XP_022448719.1};
RN [1] {ECO:0000313|RefSeq:XP_022448719.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022448719.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the immunoglobulin superfamily.
CC L1/neurofascin/NgCAM family. {ECO:0000256|ARBA:ARBA00008588}.
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DR RefSeq; XP_022448719.1; XM_022593011.2.
DR AlphaFoldDB; A0A2Y9PPC3; -.
DR Proteomes; UP000248483; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR CDD; cd00063; FN3; 4.
DR CDD; cd05868; Ig4_NrCAM; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 9.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003006; Ig/MHC_CS.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR026966; Neurofascin/L1/NrCAM_C.
DR PANTHER; PTHR44170:SF15; NEURONAL CELL ADHESION MOLECULE; 1.
DR PANTHER; PTHR44170; PROTEIN SIDEKICK; 1.
DR Pfam; PF13882; Bravo_FIGEY; 1.
DR Pfam; PF00041; fn3; 4.
DR Pfam; PF07679; I-set; 3.
DR Pfam; PF13927; Ig_3; 1.
DR SMART; SM00060; FN3; 4.
DR SMART; SM00409; IG; 4.
DR SMART; SM00408; IGc2; 4.
DR SUPFAM; SSF49265; Fibronectin type III; 2.
DR SUPFAM; SSF48726; Immunoglobulin; 4.
DR PROSITE; PS50853; FN3; 4.
DR PROSITE; PS50835; IG_LIKE; 4.
DR PROSITE; PS00290; IG_MHC; 1.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000248483};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 893..914
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 91..180
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 185..272
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 278..365
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 369..456
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 463..558
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 560..657
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 662..764
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 768..864
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT REGION 923..1028
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 923..979
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1028 AA; 113478 MW; A7D5EC37EDAA53B6 CRC64;
MSLRLSPAFQ RLPQSERVSQ GLNGDLYFSN VLPEDTREDY ICYARFNHTQ TIQQKQPISV
KVISVDELND TIAANLSDTE FYGAKSHRER PPTFLTPEGN ASRKEELRGN VLSLECIAEG
LPTPIIYWIK EDGTLSINRT FYRNFKKTLQ IVQVTEADSG NYQCIAKNAL GAIHHTISVT
VKAAPYWIIA PQNLVLSPGE DGTLICRANG NPKPRISWLL NGVPIEIAPD DPSRKIDGDT
IIFSNVQERS SAVYQCNASN EYGYLLANAF VNVLAEPPRI LTSADTLYQV IANRPALLDC
AFFGSPLPTI EWFKGAKGSA LREDIYVLHE NGTLEIPVAQ KDSTGTYTCV ARNKLGMAKN
DIHLEIKDPT RIIKQPEYAV VQRGSTVSFE CIVKHDHTLI PTVMWLKDHR ELPSDGRFTV
DKDRLVVADV NDDDGGTYTC VANTTLDNVS ASAVLSVVDV PNPPFDLELT DQLDRSVQLS
WTPGDDNNSP ITKFIIEYED AMHEPGLWHH QTEVPGAQTT AQLKLSPYVN YSFRVMAVNS
LGRSLPSEAS EQYLTKAAEP DKNPTAVEGL GSEPDNLVIT WKPLNGFESN GPGLQYKVSW
RQKDGDDEWT SMVVADVSKY IVSGTPTFVP YLIKVQALND AGFAPEPAVV LGHSGEDLPM
VAPGNVHVNV VNSTLAEVHW DPVPLKSIRG HLQGYRIYYW KAQSSSTRNR RHIEKKILTF
QGSKTHGMLP GLEPFSHYTL NVRVVNGKGE GPASPDRVFN TPEGVPSAPS SLKIVNPTLD
SLTLEWEPPS HPNGVLTEYT LKYQPINSTH ELGPLVDLKI PANKTRWTLK NLNFSTRYKF
YFYAQTAAGS GNQITEEAIT TVDEGKMAGI LPPDVGAGKA MASRQVDIAT QGWFIGLMCA
VALLILILLI VCFIRRNKGG KYPVKEKEDA HADPEIQPMK EDDGTFGEYS DAEDHKPLKK
GSRTPSDRTV KKEDSDDSLV DYGEGVNGQF NEDGSFIGQY SGKKEKEPAE GNESSEAPSP
VNAMNSFV
//
