ID   A0A2Y9PPG7_DELLE        Unreviewed;       717 AA.
AC   A0A2Y9PPG7;
DT   12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT   12-SEP-2018, sequence version 1.
DT   27-MAR-2024, entry version 19.
DE   RecName: Full=Macrophage-expressed gene 1 protein {ECO:0000256|ARBA:ARBA00021365};
DE   AltName: Full=Perforin-2 {ECO:0000256|ARBA:ARBA00030728};
GN   Name=MPEG1 {ECO:0000313|RefSeq:XP_022447610.1};
OS   Delphinapterus leucas (Beluga whale).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC   Monodontidae; Delphinapterus.
OX   NCBI_TaxID=9749 {ECO:0000313|Proteomes:UP000248483, ECO:0000313|RefSeq:XP_022447610.1};
RN   [1] {ECO:0000313|RefSeq:XP_022447610.1}
RP   IDENTIFICATION.
RC   TISSUE=Blood {ECO:0000313|RefSeq:XP_022447610.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane
CC       {ECO:0000256|ARBA:ARBA00004439}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004439}. Cytoplasmic vesicle, phagosome
CC       membrane {ECO:0000256|ARBA:ARBA00004265}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004265}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the MPEG1 family.
CC       {ECO:0000256|ARBA:ARBA00007256}.
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DR   RefSeq; XP_022447610.1; XM_022591902.1.
DR   AlphaFoldDB; A0A2Y9PPG7; -.
DR   STRING; 9749.A0A2Y9PPG7; -.
DR   Ensembl; ENSDLET00000003335; ENSDLEP00000002929; ENSDLEG00000002362.
DR   KEGG; dle:111183921; -.
DR   InParanoid; A0A2Y9PPG7; -.
DR   OrthoDB; 4221421at2759; -.
DR   Proteomes; UP000248483; Unplaced.
DR   GO; GO:0061474; C:phagolysosome membrane; IEA:Ensembl.
DR   GO; GO:0022829; F:wide pore channel activity; IEA:Ensembl.
DR   GO; GO:0002250; P:adaptive immune response; IEA:UniProtKB-KW.
DR   GO; GO:0050829; P:defense response to Gram-negative bacterium; IEA:Ensembl.
DR   GO; GO:0050830; P:defense response to Gram-positive bacterium; IEA:Ensembl.
DR   CDD; cd22579; MPEG1_P2; 1.
DR   InterPro; IPR020864; MACPF.
DR   InterPro; IPR039707; MPEG1.
DR   PANTHER; PTHR31463; MACROPHAGE-EXPRESSED GENE 1 PROTEIN; 1.
DR   PANTHER; PTHR31463:SF4; MACROPHAGE-EXPRESSED GENE 1 PROTEIN; 1.
DR   Pfam; PF01823; MACPF; 1.
DR   SMART; SM00457; MACPF; 1.
DR   PROSITE; PS51412; MACPF_2; 1.
PE   3: Inferred from homology;
KW   Adaptive immunity {ECO:0000256|ARBA:ARBA00023130};
KW   Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Immunity {ECO:0000256|ARBA:ARBA00023130};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000248483};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane beta strand {ECO:0000256|ARBA:ARBA00022452};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT   SIGNAL          1..17
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           18..717
FT                   /note="Macrophage-expressed gene 1 protein"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5015997456"
FT   TRANSMEM        656..677
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          30..345
FT                   /note="MACPF"
FT                   /evidence="ECO:0000259|PROSITE:PS51412"
SQ   SEQUENCE   717 AA;  79012 MW;  BFFF38EF9088770D CRC64;
     MNSFRGAILI WAVAAWAKMN KPLGDTDEDG FQKCKIALKL PVLAVLPGGG WDNLRNVDMG
     RVMNLTYTYC RTTEDGQYIV PDEVFTIPQK ESNLEMNSKI LESWENYQSS TSYSINMELS
     LFSKVNGKFS PEFQRMKTLQ VKDQAVTTQV QVRNLVYTVK INPDAELSWG FKKELLDISE
     RLEKNQTRMA TYLAELLVLN YGTHVITSVD AGAALIQEDH IRSSLLQDSQ SSRSAVTASA
     GITFLNIVNF KFEENHTSQN AFTKSYLSNR TNSRVQSIGG LPFYPGITLQ TWQQGITNHL
     VAMDRAGLPL YFFINPDRLP DLPGPLVKKL SKTVETAVRR YYTFNTYPGC TDINSPNFNF
     QANIDDGSCE GKMTNFSFGG VYQECTQFSG NEVVQLCRNL EQKNPLTGNF SCPSGYTPVQ
     LLSQTHEEGY NHLECSRKCT LLIFCKTVCE DVFRVAKAEF RAFWCVASGQ VPENSGLLFG
     GLFSDKSINP LTNAQSCPAG YFPLRLFENL KVCASQDYEL GYRFSVPFGG FFSCAVGNPL
     VDAAMYKDLG APSLKKCPGG FSQHLALISD GCQVSYCVKA GLFTGGSLPP VRLPPYTQPP
     LMSQAATNTV LVTNLETASS WIKDSQTHQW RLGEPLELRR AMKVIHGDGS GLSGGAAAGV
     TLGVTTILAA VIALAIYGTR KYNKRGYQAV QDERQSLVTG TAVNGDALDQ EQAQSPA
//