ID A0A2Y9PS96_DELLE Unreviewed; 573 AA.
AC A0A2Y9PS96;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=RNA helicase {ECO:0000256|ARBA:ARBA00012552};
DE EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
GN Name=DHX35 {ECO:0000313|RefSeq:XP_022448121.1};
OS Delphinapterus leucas (Beluga whale).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Monodontidae; Delphinapterus.
OX NCBI_TaxID=9749 {ECO:0000313|Proteomes:UP000248483, ECO:0000313|RefSeq:XP_022448121.1};
RN [1] {ECO:0000313|RefSeq:XP_022448121.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022448121.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC Evidence={ECO:0000256|ARBA:ARBA00001556};
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DR RefSeq; XP_022448121.1; XM_022592413.2.
DR AlphaFoldDB; A0A2Y9PS96; -.
DR Proteomes; UP000248483; Unplaced.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR CDD; cd18791; SF2_C_RHA; 1.
DR Gene3D; 1.20.120.1080; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS.
DR InterPro; IPR048333; HA2_WH.
DR InterPro; IPR007502; Helicase-assoc_dom.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR PANTHER; PTHR18934:SF136; ATP-DEPENDENT RNA HELICASE DHX35-RELATED; 1.
DR Pfam; PF21010; HA2_C; 1.
DR Pfam; PF04408; HA2_N; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF07717; OB_NTP_bind; 1.
DR SMART; SM00847; HA2; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00690; DEAH_ATP_HELICASE; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022806,
KW ECO:0000313|RefSeq:XP_022448121.1};
KW Helicase {ECO:0000256|ARBA:ARBA00022806,
KW ECO:0000313|RefSeq:XP_022448121.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022806,
KW ECO:0000313|RefSeq:XP_022448121.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000248483}.
FT DOMAIN 106..283
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 550..573
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 573 AA; 64671 MW; BD99F1F99F048397 CRC64;
MLVREMMVDP LLTKYSAIML DEAHERTLYT DIAIGLLKKI QKKRGDLRLI VASATLDAEK
FWDFFNQNDT SDPTRDTCVI LTVEGRTFPV DIFYLQSPVP DYIKSTVETV MKIHQTEGDG
DILAFLTGQE EVETVVSMLI EQARALGRTG MKRHLRVLPM YAGLPSFEQM KVFERVSRTV
RKVIVATNVA ETSITISGIV YVIDCGFVKL RAYNPRTAIE CLVVVPVSQA SASQRAGRGG
RSRSGKCYRL YTEEAFDQLP QSTVPEMQRS NLAPVILQLK ALGIDNVLRF HFMSPPPAQS
MVQALELLYA LGGLDKDCRL TEPLGMRIAE FPLNPMFAKM LLESGNFGCS QEILSIAAMM
QIQNVFVVPS NQKSQAIRVH RKFAVEEGDH LTMLNVYEAF IKHSKNSLWC QEHFLNYKGL
VRAVTVREQL KKLLVKFQVP KKSSEGDPDP VLRCIVSGFF ANAARFHSTG AYRTIRDDHE
LHIHPASVLY AEKPPRWVIY NEVIQTSKYY MRDVTAIESA WLLELAPHFY QQGTPCVWRG
TITVRGLQPR NHGFGPGPSL RVSAGPRDLI REQ
//
