ID   A0A2Y9PTA9_DELLE        Unreviewed;       476 AA.
AC   A0A2Y9PTA9;
DT   12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT   12-SEP-2018, sequence version 1.
DT   27-MAR-2024, entry version 19.
DE   RecName: Full=Cytosolic iron-sulfur assembly component 3 {ECO:0000256|ARBA:ARBA00039851};
DE   AltName: Full=Cytosolic Fe-S cluster assembly factor NARFL {ECO:0000256|ARBA:ARBA00041671};
DE   AltName: Full=Iron-only hydrogenase-like protein 1 {ECO:0000256|ARBA:ARBA00042668};
DE   AltName: Full=Nuclear prelamin A recognition factor-like protein {ECO:0000256|ARBA:ARBA00041553};
GN   Name=CIAO3 {ECO:0000313|RefSeq:XP_022450109.1};
OS   Delphinapterus leucas (Beluga whale).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC   Monodontidae; Delphinapterus.
OX   NCBI_TaxID=9749 {ECO:0000313|Proteomes:UP000248483, ECO:0000313|RefSeq:XP_022450109.1};
RN   [1] {ECO:0000313|RefSeq:XP_022450109.1}
RP   IDENTIFICATION.
RC   TISSUE=Blood {ECO:0000313|RefSeq:XP_022450109.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- FUNCTION: Component of the cytosolic iron-sulfur protein assembly (CIA)
CC       complex, a multiprotein complex that mediates the incorporation of
CC       iron-sulfur cluster into extramitochondrial Fe/S proteins. Seems to
CC       negatively regulate the level of HIF1A expression, although this effect
CC       could be indirect. {ECO:0000256|ARBA:ARBA00037412}.
CC   -!- SIMILARITY: Belongs to the NARF family.
CC       {ECO:0000256|ARBA:ARBA00006596}.
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DR   RefSeq; XP_022450109.1; XM_022594401.2.
DR   AlphaFoldDB; A0A2Y9PTA9; -.
DR   STRING; 9749.A0A2Y9PTA9; -.
DR   Ensembl; ENSDLET00000008309; ENSDLEP00000007513; ENSDLEG00000005508.
DR   KEGG; dle:111185124; -.
DR   InParanoid; A0A2Y9PTA9; -.
DR   OrthoDB; 5477067at2759; -.
DR   Proteomes; UP000248483; Unplaced.
DR   GO; GO:0097361; C:CIA complex; IEA:Ensembl.
DR   GO; GO:0002244; P:hematopoietic progenitor cell differentiation; IEA:Ensembl.
DR   GO; GO:0032364; P:intracellular oxygen homeostasis; IEA:Ensembl.
DR   GO; GO:0016226; P:iron-sulfur cluster assembly; IEA:Ensembl.
DR   GO; GO:0010468; P:regulation of gene expression; IEA:Ensembl.
DR   GO; GO:0001666; P:response to hypoxia; IEA:Ensembl.
DR   Gene3D; 3.40.50.1780; -; 1.
DR   InterPro; IPR009016; Fe_hydrogenase.
DR   InterPro; IPR004108; Fe_hydrogenase_lsu_C.
DR   InterPro; IPR003149; Fe_hydrogenase_ssu.
DR   PANTHER; PTHR11615:SF322; CYTOSOLIC IRON-SULFUR ASSEMBLY COMPONENT 3; 1.
DR   PANTHER; PTHR11615; NITRATE, FORMATE, IRON DEHYDROGENASE; 1.
DR   Pfam; PF02906; Fe_hyd_lg_C; 1.
DR   Pfam; PF02256; Fe_hyd_SSU; 1.
DR   SMART; SM00902; Fe_hyd_SSU; 1.
DR   SUPFAM; SSF53920; Fe-only hydrogenase; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000248483}.
FT   DOMAIN          410..466
FT                   /note="Iron hydrogenase small subunit"
FT                   /evidence="ECO:0000259|SMART:SM00902"
SQ   SEQUENCE   476 AA;  52907 MW;  EFB055BA9C71E496 CRC64;
     MASLFSGALQ LTDLDDFIAP SQDCIKPMRV DKRPGSGVAK IHVEDDGSYF QVSQDGGTKK
     LERAKISLDD CLACSGCVTS AETVLITQQS HEELRKVLGA NKMVAPDQQR LVVISVSPQS
     RASLAVRFQL NPTDTARKLT AFFKKIGAHY VFDTTFSRNF SLLESQREFV RRFRAQADSK
     QALPMLTSAC PGWICYAEKT HGNVLLPHIS TARSPQQVMG SLVKDFFSQQ QHLTPDKIYH
     VTVMPCYDKK LEASRPDFFS QEHQTRDVDC VITTGEVFKL LEEEGVSLSE LESAPLDSLC
     SSVSAQEPTS HQGGGSGGYL EHVFRHAAQE LFGIHVTEVT YRPLRNKDLQ EVTLEREGRV
     LLHFAAAYGF RNIQNLVQKL KRGRCPYHYV EVMACPAGCL NGGGQLKAPD MPGKELLQQV
     ERLYSMVRTE APEDAPGVQE LYGHWLQGEG SEQASRLLHT SYHAVEKAGS SLSIRW
//