ID A0A2Y9PTV5_DELLE Unreviewed; 1316 AA.
AC A0A2Y9PTV5;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=3'-5' RNA helicase YTHDC2 isoform X3 {ECO:0000313|RefSeq:XP_022446752.1};
GN Name=YTHDC2 {ECO:0000313|RefSeq:XP_022446752.1};
OS Delphinapterus leucas (Beluga whale).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Monodontidae; Delphinapterus.
OX NCBI_TaxID=9749 {ECO:0000313|Proteomes:UP000248483, ECO:0000313|RefSeq:XP_022446752.1};
RN [1] {ECO:0000313|RefSeq:XP_022446752.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022446752.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_022446752.1; XM_022591044.2.
DR Proteomes; UP000248483; Unplaced.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR CDD; cd17987; DEXHc_YTHDC2; 1.
DR CDD; cd18791; SF2_C_RHA; 1.
DR CDD; cd21134; YTH; 1.
DR Gene3D; 1.20.120.1080; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 3.10.590.10; ph1033 like domains; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR048333; HA2_WH.
DR InterPro; IPR007502; Helicase-assoc_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR007275; YTH_domain.
DR PANTHER; PTHR18934:SF213; 3'-5' RNA HELICASE YTHDC2; 1.
DR PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF21010; HA2_C; 1.
DR Pfam; PF04408; HA2_N; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF07717; OB_NTP_bind; 1.
DR Pfam; PF04146; YTH; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00847; HA2; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS50088; ANK_REPEAT; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
DR PROSITE; PS50882; YTH; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806,
KW ECO:0000313|RefSeq:XP_022446752.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022806,
KW ECO:0000313|RefSeq:XP_022446752.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000248483}.
FT DOMAIN 90..256
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT REPEAT 393..425
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 499..671
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT DOMAIN 1174..1304
FT /note="YTH"
FT /evidence="ECO:0000259|PROSITE:PS50882"
FT REGION 1052..1174
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1075..1089
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1119..1136
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1137..1166
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1316 AA; 148536 MW; 0F1D2DA151ADE9D7 CRC64;
MMTCNLTHNT KHAVRSLIQR FPVTSKERTE LLPKTERGNV FAVEAENREM SKTSGRLNSG
LSQIPVKRGE SEFDSFRQSL PVFEKQEEIV KIIKENKVVL IVGETGSGKT TQIPQFLLDD
CFKNGIPCRI FCTQPRRLAA IAVAERVAAE RRERIGQTIG YQIRLESRVS PKTLLTFCTN
GVLLRTLMAG DSSLSTVTHV IVDEVHERDR FSDFLLTKLR DLLQKYPTLK LILSSAALDV
NLFMRYFGSC PVTYIQGRPF EVKEMFLEDI LRTTGYTNKE MLKYKKEKQR EERQQTTLTE
WYSAQENTFK PESQRQRAVP NVTEENDLLD DGGDAAFSQL TEKDVNCLEP WLIKEMDACL
SDIWLRKDVD AFAQVFHLIL TENVSVDYRH SETSATALMV AAGRGFSSQV EQLISMGANI
HIKASNGWMA LDWAKHFGQT EIVDLLESYS ASLEFGNLDE SSLVQTNGSD LSAEDRELLK
AYHHSFDDEK VDLDLIMHLL YNICHSCDSG AILIFLPGYD EIVGLRDRIL FDDRRFADNT
HRYQVFMLHS NMQTSDQKKI LKNPPAGVRK IILSTNIAET SITVNDVVFV IDSGKVKEKS
FDALNFVTML KMVWISKASA IQRKGRAGRC RPGICFRLFS RLRFQNMLEF QTPELLRMPL
QELCLHTKLL APVNCPIADF LMKAPEPPPT LIVRNAVHML KTIDAMDAWE DLTELGYHLA
DLPVEPHLGK MVLCAVVLKC LDPILTIACT LAYRDPFVLP TQASQKRAAM LCRKRFTAGT
FSDHMALLRA FQAWQKARSD GWERAFCEKN FLSQATLEII IGMRTQLLGQ LRASGFVRAR
GGGDIRDVNT NSENWAVVKA ALVAGMYPHL VHVDRENVVL TGPKEKKVRF HPTSVLSQSH
YKKIPPANGQ AAAIQALPTD WLIYDEMTRA HRIANIRCCS AVTPVTVLIF CGPARLASNA
LQELSSFRAD GIPNDSSDSE MEDRTTANLA ALKLDEWLNF KLEPEAASLL LQLRQKWHSL
FLRRMRAPSK PWSQVDDATI RAIIAVLSTE EQSAGLQQPS GIGQRPRPMS SEELPLASSW
RSNNSRKISA DTEFSDESTT AERVLMKSPS PALHPPQKYK DRGILHPKRS TDDRSDQSSV
NTDSNNYQSP CASPSPPSSG KGSKSPSPRP NMPIRYFIMK SSNLRNLEIS QQKGIWSTTS
SNERKLNRAF WESSMVYLIF SVQGSGHFQG FSRMSSEIGR EKSQDWGSAG LGGVFKVEWI
RKESLPFQFA HHLLNPWNDN KKVQISRDGQ ELEPQVGEQL LQLWERLSLG EKTTTD
//
