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Database: UniProt
Entry: A0A2Y9PU68_DELLE
LinkDB: A0A2Y9PU68_DELLE
Original site: A0A2Y9PU68_DELLE 
ID   A0A2Y9PU68_DELLE        Unreviewed;      3077 AA.
AC   A0A2Y9PU68;
DT   12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT   12-SEP-2018, sequence version 1.
DT   10-FEB-2021, entry version 11.
DE   SubName: Full=centromere protein F {ECO:0000313|RefSeq:XP_022449095.1};
GN   Name=CENPF {ECO:0000313|RefSeq:XP_022449095.1};
OS   Delphinapterus leucas (Beluga whale).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC   Monodontidae; Delphinapterus.
OX   NCBI_TaxID=9749 {ECO:0000313|Proteomes:UP000248483, ECO:0000313|RefSeq:XP_022449095.1};
RN   [1] {ECO:0000313|RefSeq:XP_022449095.1}
RP   IDENTIFICATION.
RC   TISSUE=Blood {ECO:0000313|RefSeq:XP_022449095.1};
RG   RefSeq;
RL   Submitted (OCT-2020) to UniProtKB.
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DR   RefSeq; XP_022449095.1; XM_022593387.1.
DR   Ensembl; ENSDLET00000007627; ENSDLEP00000006883; ENSDLEG00000005094.
DR   KEGG; dle:111184678; -.
DR   Proteomes; UP000248483; Genome assembly.
DR   GO; GO:0097539; C:ciliary transition fiber; IEA:Ensembl.
DR   GO; GO:0000940; C:condensed chromosome outer kinetochore; IEA:Ensembl.
DR   GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR   GO; GO:0030496; C:midbody; IEA:Ensembl.
DR   GO; GO:0005635; C:nuclear envelope; IEA:Ensembl.
DR   GO; GO:0016363; C:nuclear matrix; IEA:Ensembl.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0000922; C:spindle pole; IEA:Ensembl.
DR   GO; GO:0070840; F:dynein complex binding; IEA:Ensembl.
DR   GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR   GO; GO:0008022; F:protein C-terminus binding; IEA:Ensembl.
DR   GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
DR   GO; GO:0008134; F:transcription factor binding; IEA:Ensembl.
DR   GO; GO:0001822; P:kidney development; IEA:Ensembl.
DR   GO; GO:0051310; P:metaphase plate congression; IEA:Ensembl.
DR   GO; GO:0000278; P:mitotic cell cycle; IEA:Ensembl.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:Ensembl.
DR   GO; GO:0015031; P:protein transport; IEA:Ensembl.
DR   GO; GO:0010389; P:regulation of G2/M transition of mitotic cell cycle; IEA:Ensembl.
DR   GO; GO:0021591; P:ventricular system development; IEA:Ensembl.
DR   InterPro; IPR043513; Cenp-F.
DR   InterPro; IPR018302; CenpF/LEK1_Rb-prot-bd.
DR   InterPro; IPR019513; Centromere_CenpF_leu-rich_rpt.
DR   InterPro; IPR018463; Centromere_CenpF_N.
DR   PANTHER; PTHR18874; PTHR18874; 2.
DR   Pfam; PF10490; CENP-F_C_Rb_bdg; 1.
DR   Pfam; PF10473; CENP-F_leu_zip; 2.
DR   Pfam; PF10481; CENP-F_N; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Reference proteome {ECO:0000313|Proteomes:UP000248483}.
FT   DOMAIN          1..307
FT                   /note="CENP-F_N"
FT                   /evidence="ECO:0000259|Pfam:PF10481"
FT   DOMAIN          2094..2233
FT                   /note="CENP-F_leu_zip"
FT                   /evidence="ECO:0000259|Pfam:PF10473"
FT   DOMAIN          2277..2415
FT                   /note="CENP-F_leu_zip"
FT                   /evidence="ECO:0000259|Pfam:PF10473"
FT   DOMAIN          2932..2976
FT                   /note="CENP-F_C_Rb_bdg"
FT                   /evidence="ECO:0000259|Pfam:PF10490"
FT   REGION          460..497
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          808..827
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1241..1260
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1363..1386
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          2854..3077
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          13..138
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          164..191
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          280..384
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          509..615
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          623..706
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          718..759
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          839..873
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          899..957
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          969..989
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1036..1056
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1089..1109
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1118..1159
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1203..1230
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1285..1326
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1578..1616
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1789..1851
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1885..1905
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1927..2048
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2070..2097
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2105..2248
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2287..2314
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2319..2339
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2343..2423
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2438..2458
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2466..2566
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2592..2619
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2652..2788
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2799..2826
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        475..497
FT                   /note="Polyampholyte"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1243..1260
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1370..1386
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2854..2895
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2914..2934
FT                   /note="Polyampholyte"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2962..2976
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2992..3043
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   3077 AA;  353397 MW;  217C878FA567929F CRC64;
     MSWALEEWKE GLPTRALQKI QELEGQLDKL KKERQQRQFQ LETLEAALQK QKQKVENEKA
     EGANLKRENQ SLMEICENLE KTKQKISHEL QVKESQVNFQ EGQLNSSKKQ IEKLEQELKR
     CKSELERSQQ AAQSADASLS PCTTPQKIFA TPLTPSQYYS GSKYEDLKEK YNKEVEERKR
     LEAEVKALQA KKASQATPQS TMNHRDIARH QASSSVFSWQ QEKTPSRLSS NVLKTPIRRD
     FSASSFSGEQ EVTLSRSTLQ IGNRDANSSF CDNSSNSHLL DQFKAQNQEL RSKISELELR
     LQGQEREMKG QVNKLQELQL QVEKAKVELN EKEKVLNKSR DELVRTTAQY DQASTKCIAL
     EQKLKKLTED LSCQRQNAES ARCSLEQKIK EKEKEFQEEL SRQQRSFQTL DQEFTQMKAK
     LTQELQQAKN MHNILQAELD KVTSVKHQLE KKLEEFKEKF SRTEQTLQAS QTKENELRRS
     SEEMKRENSL LKSQSEQRAR EVCHLEEELK KAKQRLSQSQ NFAEEMRAKN TSQETMLRDL
     QEKINQQENS LTLEKLKLAL ADLEKQRDCS QDLLKKREHH IEQLNEKLSQ TERESEALLS
     ALELKKKEYE ELKEEKTLFS LWKSENEQLL NQMESEKESL QSKINHLETC LKTQQIKSHE
     YNERVRTLEM ERENLNVEIR NLHNVIDSKT AEAETQKQAY GELQQKAEFS DQKHEKEIEN
     MCLKISQLTR QVEDLEDKLQ SLSSEIMDKN QRYQDLHAES ESLRDLLKSR DSSAVTNESH
     QRSLLAFEQQ FAANNSFANI FEEQESVPSE RSECHLETDQ SPKSSSMLQN RVVSLEFSLE
     SQKQMNSDLQ KQCEELVQIK GEIEENLMKA EQMHQSFVAE TSQRISKLQE DTSVHQNVVV
     ETLAALESKE RELQLLNEKL ETEQAEIQEL KKSNHLLQES LKELQLLSET LSLEKKEMSS
     IISLDKKDIE ELTQENGTLK EINATLTQEK MNLLQKTESF SNCIDERDKS ISELSDQYKQ
     ERLTLLQRCE ETGNAFRDLS EKYKAEQEKN SKLECLLNEC TSVCEDRKNE LGQLKETFAR
     EHQAFVSQLA LAEERNQSLI LELETMQQAL RSEVTDIQSN SKREADSLKQ EIMTLKEEQS
     KMQQEVNALL QEKEHLMELM KTKHEHQHLE LEPIQDSVKV AERKINTHYV QLPMDLEVKD
     ASLDSYNAQL AQVETKVRNM ELKLQESEKE EYLQHELQTG GELETGDVQQ GTQSQDISGL
     GNFEIDPEEK YISVLHELST SQQDNAHLQC SLQTAMNKLD ELEKMCEALQ VEKLELISEL
     NDSRSECVTA TSKMAEEVGK LVNEVKILND ENGLLQGEFV KETPESEFGE QQDEQTSVSL
     NPLDDSNSYE HLTVSNKEVR MHFAELQEKF SSLQSEHKIL HDQHCQMSSK MSELQSYIDT
     LKAENSVLSM SLRNSQGDLV KEVMPGPGEK HFLSLSLSGV TDSPGNAIES SFYKDLLEHM
     GETSLLNNLD RTVLANQSSV EKVSCSSLEE ENLTEKEIPS APVRSVEELG TVSQMYLQSF
     KKLEEKIESQ GITKNKEIEE LERLLSSSRE ELDCLRKQYL SENEQWQQKL TSVTAEMESK
     LAAEKKHTEH LTLELEVARL QLQGLDLSSR SLLGTDIDDA IRGGDDSCEI RELEDYTSET
     NERTPKHEIH QICEKDVQQD LSLEMEKITK TSAIKLIGEW SGEQSPETSH RTPVEDTTQG
     CSECISELSL SGPDASVPMD FLENQVTIQT LQLQVKETSD ENLRLLHGIK ERDQKVESLL
     NEIKELDSKL NLQEVQLTTK IEACIELEKI VEELKKEKSD FSEKLESFSR DNQRVESSGG
     LTSNLEMGTD KLSHEGIEDE VAKVTDNWRE RCLNVENELQ RVKAERGSTE HHALSAEANL
     EVVQTEKLFL EKDNENKQKV INCLEEELLV VTSERDQLRG ELDTLSKENQ ELDQMSEKMK
     EKIQELESHQ DEYLHLQEQL QSLEKDSQAL SLVRSELENQ IRQLNKETKS LVRESESLQT
     KLSELEHEKL TVTKALEAAL MEKGEVAVRL SSTQEEVHQL RKGIEQLRVR IEADEKKQLH
     ISEKLKESER RNDSLQDKVE TLERELHMAE ENQELVILDA ENSKAEVETL KTQMELMTES
     LKALDLDLVT IRSEKENLVK QLQEKQGQVS ELHTLLSSLK NVLEEKEREK IQMKEESKAV
     VEILQTQLKE LSEEVAALCD DQETWKAEEQ SLDSPVQEVH QLRNNIGKLK VHLDTNERKQ
     LHILEKLKES EHQAALLKDT VENLERELEV SGKNQEHVIL EAEKSKAEVE TLKAKIEEMA
     PNLRALELDL VNTRSEKEDL TKELQKEQGR VSELETLNSS FENLLQEKEQ EKEQMKEESK
     AVVEILQTQL KELSEEVAAL CDDQETWKVE EQSLSSQVDS LEHEKAQLLQ GLDEAKSNYM
     LLQSSVNGLI QEVEDGKQKL EKKDEEIRIL KNHIQDQEQL VSKLSQMEGE QQLWEEQRTK
     LENLMVELEQ KTQVLQSKND TLQDTLEALQ NSSKDLEKEL QLTKMEKLSF VEKVNTMTVK
     ETELQKEMLA MVQKTTELKE EFSREKNRLT EDLKLVSEEM KSRKGQLKEL ILENSELKKS
     LDCVHKDQME KQGKMREEIA EYQLRLQEAE KKHQALLLDI NKQYEMEIQT YREKLTSKEE
     CLSSQKVEID LLKSSKEELN NSLKVTTEIL EELKKTKMEN LKYADKLKKE NDRAQGKIKL
     LIKSCKQLEE EKGMLQKEVS HLEAAQEKQK AGTVVDANVD ELMTEMKELK ETLEEKTKEA
     DEYLDKYCSL LISHEKLEKA KEMLETQVAR LSSQQSKLNL RSSPSLNSVV PGPSPVPSAT
     EKKLSSGQNK ASGKRQRSGG IREDGGETTP STPEKFSKKS RKAVKSGIHP AEDAEDAEPE
     PEGLPEVVKK GFADIPTGKT SPYILRRTTM VTRTSPRLAA QKLAPSPLSL DKENLAETSK
     PTAGGNRSQK VKVTQQSPVD SGTALREPTT RSLSISNLPE RSSADSPREG LRAKQGRLAP
     SPEAGPESKG SENCRVQ
//
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