ID A0A2Y9PUQ8_DELLE Unreviewed; 491 AA.
AC A0A2Y9PUQ8;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=LOW QUALITY PROTEIN: cathepsin F {ECO:0000313|RefSeq:XP_022447067.1};
GN Name=CTSF {ECO:0000313|RefSeq:XP_022447067.1};
OS Delphinapterus leucas (Beluga whale).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Monodontidae; Delphinapterus.
OX NCBI_TaxID=9749 {ECO:0000313|Proteomes:UP000248483, ECO:0000313|RefSeq:XP_022447067.1};
RN [1] {ECO:0000313|RefSeq:XP_022447067.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022447067.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Lysosome {ECO:0000256|ARBA:ARBA00004371}.
CC -!- SIMILARITY: Belongs to the peptidase C1 family.
CC {ECO:0000256|ARBA:ARBA00008455}.
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DR RefSeq; XP_022447067.1; XM_022591359.1.
DR AlphaFoldDB; A0A2Y9PUQ8; -.
DR STRING; 9749.A0A2Y9PUQ8; -.
DR KEGG; dle:111183702; -.
DR InParanoid; A0A2Y9PUQ8; -.
DR OrthoDB; 1085298at2759; -.
DR Proteomes; UP000248483; Unplaced.
DR GO; GO:0005764; C:lysosome; IEA:UniProtKB-SubCell.
DR GO; GO:0008234; F:cysteine-type peptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd02248; Peptidase_C1A; 1.
DR Gene3D; 1.10.287.2250; -; 1.
DR Gene3D; 3.10.450.10; -; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR InterPro; IPR046350; Cystatin_sf.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR000169; Pept_cys_AS.
DR InterPro; IPR025660; Pept_his_AS.
DR InterPro; IPR013128; Peptidase_C1A.
DR InterPro; IPR000668; Peptidase_C1A_C.
DR InterPro; IPR039417; Peptidase_C1A_papain-like.
DR InterPro; IPR013201; Prot_inhib_I29.
DR PANTHER; PTHR12411:SF444; CATHEPSIN F; 1.
DR PANTHER; PTHR12411; CYSTEINE PROTEASE FAMILY C1-RELATED; 1.
DR Pfam; PF08246; Inhibitor_I29; 1.
DR Pfam; PF00112; Peptidase_C1; 1.
DR PRINTS; PR00705; PAPAIN.
DR SMART; SM00848; Inhibitor_I29; 1.
DR SMART; SM00645; Pept_C1; 1.
DR SUPFAM; SSF54403; Cystatin/monellin; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR PROSITE; PS00139; THIOL_PROTEASE_CYS; 1.
DR PROSITE; PS00639; THIOL_PROTEASE_HIS; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Lysosome {ECO:0000256|ARBA:ARBA00023228};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000248483};
KW Signal {ECO:0000256|SAM:SignalP};
KW Thiol protease {ECO:0000256|ARBA:ARBA00022807};
KW Zymogen {ECO:0000256|ARBA:ARBA00023145}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..491
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018755573"
FT DOMAIN 194..251
FT /note="Cathepsin propeptide inhibitor"
FT /evidence="ECO:0000259|SMART:SM00848"
FT DOMAIN 278..489
FT /note="Peptidase C1A papain C-terminal"
FT /evidence="ECO:0000259|SMART:SM00645"
SQ SEQUENCE 491 AA; 54298 MW; D75438BA629D378E CRC64;
MAPWLQLLLL LGLLPGTAPA PNEPRAAGAQ AWELASPELL EPARFALEMY NRGRAARTRA
ALRVVRGRVR RAGRGSLYSL KATLVEPPCN DPTVCQLRVS KKTLLCSFEV LDELGKHTLL
RWDCGPADTK ITGAGIPRDA GIAQVRLPSG VSPDSSLFQP SPPDDKNETF SSFLPLLNKD
PLPQDFSVKM ASIFKDFVTT YNRTYETTEE ARWRMSVFAN NMVRAQKIQA LDRGTARYGV
TKFSDLTEEE FRTIYLNPLL KEEPGKKMRL AQSIPDLPPP EWDWRSKGAV TKVKDQGMCG
SCWAFSVTGN VEGQWFLKRG SLLSLSEQEL LDCDKVDKAC LGGLPSNAYS AIRTLGGLET
EDDYSYHGHL QACSFSAEKA KVYINDSVEL SQNEQKLAAW LAKKGPISVA INAFGMQFYR
HGISHPLRPL CSPWLIDHAV LLVGYGNRSA TPFWAIKNSW GTDWGEEGYY YLHRGSGACG
VNVMASSAVV D
//
