ID A0A2Y9PV42_DELLE Unreviewed; 1869 AA.
AC A0A2Y9PV42;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Dedicator of cytokinesis protein 5 isoform X1 {ECO:0000313|RefSeq:XP_022450739.1};
GN Name=DOCK5 {ECO:0000313|RefSeq:XP_022450739.1};
OS Delphinapterus leucas (Beluga whale).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Monodontidae; Delphinapterus.
OX NCBI_TaxID=9749 {ECO:0000313|Proteomes:UP000248483, ECO:0000313|RefSeq:XP_022450739.1};
RN [1] {ECO:0000313|RefSeq:XP_022450739.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022450739.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the DOCK family. {ECO:0000256|PROSITE-
CC ProRule:PRU00983}.
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DR RefSeq; XP_022450739.1; XM_022595031.2.
DR STRING; 9749.A0A2Y9PV42; -.
DR KEGG; dle:111185421; -.
DR InParanoid; A0A2Y9PV42; -.
DR OrthoDB; 8258at2759; -.
DR Proteomes; UP000248483; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0016477; P:cell migration; IEA:InterPro.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd11708; DHR2_DOCK5; 1.
DR CDD; cd12051; SH3_DOCK1_5_A; 1.
DR Gene3D; 1.20.58.740; -; 1.
DR Gene3D; 1.25.40.410; -; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 1.20.1270.350; Dedicator of cytokinesis N-terminal subdomain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR027007; C2_DOCK-type_domain.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR030717; DHR2_DOCK5.
DR InterPro; IPR026791; DOCK.
DR InterPro; IPR047025; DOCK1_5_SH3.
DR InterPro; IPR043161; DOCK_C_lobe_A.
DR InterPro; IPR043162; DOCK_C_lobe_C.
DR InterPro; IPR032376; DOCK_N.
DR InterPro; IPR042455; DOCK_N_sub1.
DR InterPro; IPR027357; DOCKER_dom.
DR InterPro; IPR046769; DOCKER_Lobe_A.
DR InterPro; IPR046770; DOCKER_Lobe_B.
DR InterPro; IPR046773; DOCKER_Lobe_C.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR45653; DEDICATOR OF CYTOKINESIS; 1.
DR PANTHER; PTHR45653:SF3; DEDICATOR OF CYTOKINESIS PROTEIN 5; 1.
DR Pfam; PF06920; DHR-2_Lobe_A; 1.
DR Pfam; PF20422; DHR-2_Lobe_B; 1.
DR Pfam; PF20421; DHR-2_Lobe_C; 1.
DR Pfam; PF14429; DOCK-C2; 1.
DR Pfam; PF16172; DOCK_N; 1.
DR Pfam; PF00018; SH3_1; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS51650; C2_DOCK; 1.
DR PROSITE; PS51651; DOCKER; 1.
DR PROSITE; PS50002; SH3; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000248483};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 8..69
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 443..627
FT /note="C2 DOCK-type"
FT /evidence="ECO:0000259|PROSITE:PS51650"
FT DOMAIN 1231..1642
FT /note="DOCKER"
FT /evidence="ECO:0000259|PROSITE:PS51651"
FT REGION 1679..1869
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1679..1694
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1709..1740
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1762..1783
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1794..1809
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1869 AA; 215209 MW; 0B8A1BD290FD225E CRC64;
MARWIPTKRQ KYGVAIYNYN ASQDVELSLQ VGDTVHILEM YEGWYRGYTL QNKSKKGIFP
ETYIHLKEAT VEDRGQHETV IPGELPLVQE LTSTLREWAV IWRKLYVNNK VTLFRQLQQM
TYSLIEWRSQ ILSGTLPKDE LAELKMKVTA KIDHGNRMLG LDLVVRDDNG NILDPDETST
IALFKAHEVA SKRIEEKIQE EKSILQNLDL RGQSIFSAVH TYGLYVNFKN FVCNIGEDAE
LFMALYDPDQ STFISENYLI RWGSNGMPKE IEKLNNLQAV FTDLSSTDLI RPRISLVCQI
VRVGHMELKE GKKHTCGLRR PFGVAVMDIT DIIHGKVDDE EKQHFIPFQQ IAMETYIRQR
QLIMSPLITS HVIGENEPLT SVLNKVIAAK EVNHKGQGLW VSLKLLPGDL TQVQKNFSHL
VDRSTAIARK MGFPEIILPG DVRNDIYVTL IHGEFDKGKK KTPKNVEVTM SVYDEEGRLL
EKAIHPGAGY EGISEYKSVV YYQVKQPCWY ETVKVSIAIE EVARCHIRFT FRHRSSQESR
DKSERAFGVA FVKLMNPDGT TLQDGRHDLV LYKGDNKKME DAKFYLTLPG TKVEMEEKEL
QASKTPANFT PNKDSTKDSF QVATLICSTK LTQNVDLLGL LNWRSNPQNI KHNLKKLMEV
DGGEIVKFLQ DTLDALFNIM MEMSDDETYD FLVFDALVFI ISLIGDIKFQ HFNPVLETYI
YKHFSATLAY VKLSKVLNFY VANADDSSKT ELRFAALKAL KYLFRFIIQS RVLYLRFYGQ
SEDGDEFSNS IRQLFLAFNM LMDRPLEEAV KIKGAALKYL PSIINDVKLV FDPVELSVLF
CKFIQSIPDN QLVRQKLNCM TKIVESNLFR QSECRDVLLP LLIDQLSGQL DDNSSKPDHE
ASSQLLSYLL EVLDRKDVGP TALHVQLIME RLLRRINRTV IGMSRQSPHI GSFIACMIAI
LRQMDESHYS HYISTFKTRQ DIIDFLMETF IMFKDLIGKN VYAKDWMVMN MTQSRVFLRA
INQFAEVLTR FFMDQASFEL QLWNNYFHLA VAFLTHESLQ LETFSQAKRN KIVKKYGDMR
KEIGFRIRDM WYNLGPHKIK FIPSMVGPIL EVTLTPEVEL RKATIPIFFD MMQCEFNFSG
NGNFHMFENE LITKLDQEVE GGRGDEQYKV LLEKLLLEHC RKHKYLSSSG EVFALLVSSL
LENLLDYRTI IMHDESKENR MSCTVNVLNF YKEKKREDIY IRYLYKLRDL HRDCENYTEA
AYTLLLHAEL LQWSDKPCVP HLLQRDTYYV YTQQELKEKL YQEIISYFDK GKMWEKAIKL
SKELAENYES KVFDYEGLGD LLKKRASFYE NIIKAMRPQP EYFAVGYYGQ GFPSFLRNKI
FIYRGKEYER REDFSLRLLT QFPNAEKMAS TTPPGEDIKS SPKQHMQCFT VKPVMSLPPS
YKDKPVPEQI LNYYRANEVQ QFRYSRPFRK GEKDPDNEFA TMWIERTTYT TAYTFPGILK
WFEVKQISTE EISPLENAIE TMELTNEKIS NCVQQHAWDR SLSVHPLSML LSGIVDPAVM
GGYSNYEKAF FTEKYLQEHP EDQEKIELLK RLIALQMPLL TEGIRIHGEK LTEQLKPLHD
RLSSCFRELK EKVEKLYGVI TLPPNLTERK QNRTGSMLLP YIMSSTLRRL SITSVTSSVI
SSSSNSSDNA PSRPGSDGSI LEPLLERRAS SGARVEDLSL KEDSENRMSK FKRKDWSLSK
SQVIAEKASE PDLMSPARKA QRPKSLQLSD NRLTPFHGSS LPQSTPLSPP PLTPKATRTL
SSPSLQTDGL VMATVPPPPP PKSKPYESSQ RNSTEIAAPL PVLREAKAPP PPPPKARKSG
ILSSEPGSQ
//
