ID A0A2Y9PV47_DELLE Unreviewed; 373 AA.
AC A0A2Y9PV47;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=L-threonine 3-dehydrogenase, mitochondrial {ECO:0000313|RefSeq:XP_022450744.1};
GN Name=LOC111185424 {ECO:0000313|RefSeq:XP_022450744.1};
OS Delphinapterus leucas (Beluga whale).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Monodontidae; Delphinapterus.
OX NCBI_TaxID=9749 {ECO:0000313|Proteomes:UP000248483, ECO:0000313|RefSeq:XP_022450744.1};
RN [1] {ECO:0000313|RefSeq:XP_022450744.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022450744.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the NAD(P)-dependent epimerase/dehydratase
CC family. {ECO:0000256|ARBA:ARBA00007637}.
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DR RefSeq; XP_022450744.1; XM_022595036.2.
DR AlphaFoldDB; A0A2Y9PV47; -.
DR STRING; 9749.A0A2Y9PV47; -.
DR Ensembl; ENSDLET00000000363; ENSDLEP00000000268; ENSDLEG00000000315.
DR KEGG; dle:111185424; -.
DR InParanoid; A0A2Y9PV47; -.
DR OrthoDB; 177053at2759; -.
DR Proteomes; UP000248483; Unplaced.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0008743; F:L-threonine 3-dehydrogenase activity; IEA:Ensembl.
DR GO; GO:0006567; P:threonine catabolic process; IEA:Ensembl.
DR CDD; cd05272; TDH_SDR_e; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR001509; Epimerase_deHydtase.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR42687; L-THREONINE 3-DEHYDROGENASE; 1.
DR PANTHER; PTHR42687:SF1; L-THREONINE 3-DEHYDROGENASE, MITOCHONDRIAL; 1.
DR Pfam; PF01370; Epimerase; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000248483}.
FT DOMAIN 58..293
FT /note="NAD-dependent epimerase/dehydratase"
FT /evidence="ECO:0000259|Pfam:PF01370"
SQ SEQUENCE 373 AA; 41743 MW; 771F9E3A2B4D8703 CRC64;
MPVVWMLRRV ASRMLQRPAC GCQAPVLPSR FLGTSPQQIP ADANFHSTSF SEADQPRVLI
TGGLGQLGVG LASFLRKRFG KDNVILSDIR KPPEHVFLSG PFIYSDILDY KNLREIVVNN
RVTWLFHYSA LLSAVGEANV SLARAVNITG LHNVLDVAEE HGLRLFVPST IGAFGPTSPR
NPAPDLCIQR PRTIYGVSKV HAELMGEYYY YRYGLDFRCL RYPGIISADS QPGGGTTDYA
VQIFHDAVKN GRFECNLKPS TRLPMMYIDD CLRATLEVME APAESLSMRT YNVNAMSFTP
AELAQEILKH VPEFQITYNV DPVRQAIADG WPMNFDDSNA RKDWGWKHDF DLPELVTTML
NFHGSESRVA QAN
//
