ID   A0A2Y9PVC2_DELLE        Unreviewed;       846 AA.
AC   A0A2Y9PVC2;
DT   12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT   12-SEP-2018, sequence version 1.
DT   27-MAR-2024, entry version 18.
DE   SubName: Full=Carnosine synthase 1 isoform X4 {ECO:0000313|RefSeq:XP_022446978.1};
GN   Name=CARNS1 {ECO:0000313|RefSeq:XP_022446978.1};
OS   Delphinapterus leucas (Beluga whale).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC   Monodontidae; Delphinapterus.
OX   NCBI_TaxID=9749 {ECO:0000313|Proteomes:UP000248483, ECO:0000313|RefSeq:XP_022446978.1};
RN   [1] {ECO:0000313|RefSeq:XP_022446978.1}
RP   IDENTIFICATION.
RC   TISSUE=Blood {ECO:0000313|RefSeq:XP_022446978.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   RefSeq; XP_022446978.1; XM_022591270.1.
DR   AlphaFoldDB; A0A2Y9PVC2; -.
DR   Proteomes; UP000248483; Unplaced.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0047730; F:carnosine synthase activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR   GO; GO:0035499; P:carnosine biosynthetic process; IEA:InterPro.
DR   Gene3D; 3.40.50.20; -; 1.
DR   Gene3D; 3.30.470.20; ATP-grasp fold, B domain; 1.
DR   InterPro; IPR011761; ATP-grasp.
DR   InterPro; IPR041472; BL00235/CARNS1_N.
DR   InterPro; IPR031046; CARNS1.
DR   PANTHER; PTHR48066; CARNOSINE SYNTHASE 1; 1.
DR   PANTHER; PTHR48066:SF1; CARNOSINE SYNTHASE 1; 1.
DR   Pfam; PF18130; ATPgrasp_N; 1.
DR   Pfam; PF15632; ATPgrasp_Ter; 1.
DR   SUPFAM; SSF56059; Glutathione synthetase ATP-binding domain-like; 1.
DR   PROSITE; PS50975; ATP_GRASP; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|PROSITE-ProRule:PRU00409};
KW   Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU00409};
KW   Reference proteome {ECO:0000313|Proteomes:UP000248483};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           21..846
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5016177117"
FT   DOMAIN          535..739
FT                   /note="ATP-grasp"
FT                   /evidence="ECO:0000259|PROSITE:PS50975"
SQ   SEQUENCE   846 AA;  90666 MW;  9BBA0B2E4442F051 CRC64;
     MGALSPPWPA TLLPLPTGNM LLCLSPAWLT KVPAPGQPGE AALLVSKAVS FHPGGLTFLD
     DFVPPRRATY FLAGLGLGPG RGREAAELAR DLTCPTGASA ELARLLEDRL LTRRLLARQG
     DVSVPATLAF TYKPPALLRG GDASPGLRLV ELNGKEGQET LVKEEVGAFL HSEALGDALQ
     VAMKLSGWRW RGRQAMRLYP RAELGPVVDT VLALLEKLEE EESVLVEAVC PPAQLPFPGS
     PLPGPELALR ICAVVCRTQG DRPLLSKVVC SVGRGDRPLR HQSSLPRTLE AALAQCGLGE
     ASQVAVVRQR VKAAAEAALA AVLTLEAGLS AEQRGGRQVR TDFLGVDFAL TVAGRALTPV
     ALELNGGLCL EACGALEGLW AAPRPGLAAE EAAAAPLVET MLRRSARCLM EGKQLLLLGA
     GGVSKKFVWE AARDYGLKLH LVDSDPNHFA SQLVQTFIHF NITEHQRDEE NARVLAELVR
     ARGLQLDGCF SYWDDCLVLT SLLCQELGLP CNPPAAMHLA KQKSRTQLHL LCHHGPPWPA
     PSLYAVPCCP LESEADVDRA VRQVPLPGVM KLEFGAGAVG VRLVEDASQC HEHFSRIARD
     LQGEADHPGI GLGWGNAMLL MEFIEGTEHD VDLVLFGGRL LAAFVSDNGP TRLPGFTETA
     ACMPTGLAPE QEAQLVQAAF RCCLGCGLLD GVFNVELKLT RAGPRLIEIN PRMGGFYLRD
     WILELYGVDL LLAAAMVACG LRPALPAHPR ARGHLVGVMC LVSQHLQVLS STASRETLQA
     LHDQGLLRLN LLEETLVPGE YEEPYCSVAC AGPSPAEARL RLLGLCQGLG IDGPHYPVAY
     FLSHFK
//