ID   A0A2Y9PWL8_DELLE        Unreviewed;       389 AA.
AC   A0A2Y9PWL8;
DT   12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT   12-SEP-2018, sequence version 1.
DT   27-MAR-2024, entry version 21.
DE   SubName: Full=Ectonucleoside triphosphate diphosphohydrolase 6 isoform X3 {ECO:0000313|RefSeq:XP_022449880.1};
GN   Name=ENTPD6 {ECO:0000313|RefSeq:XP_022449880.1};
OS   Delphinapterus leucas (Beluga whale).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC   Monodontidae; Delphinapterus.
OX   NCBI_TaxID=9749 {ECO:0000313|Proteomes:UP000248483, ECO:0000313|RefSeq:XP_022449880.1};
RN   [1] {ECO:0000313|RefSeq:XP_022449880.1}
RP   IDENTIFICATION.
RC   TISSUE=Blood {ECO:0000313|RefSeq:XP_022449880.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|ARBA:ARBA00001946};
CC   -!- SIMILARITY: Belongs to the GDA1/CD39 NTPase family.
CC       {ECO:0000256|ARBA:ARBA00009283, ECO:0000256|RuleBase:RU003833}.
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DR   RefSeq; XP_022449880.1; XM_022594172.1.
DR   AlphaFoldDB; A0A2Y9PWL8; -.
DR   Proteomes; UP000248483; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   CDD; cd00012; NBD_sugar-kinase_HSP70_actin; 1.
DR   Gene3D; 3.30.420.40; -; 1.
DR   Gene3D; 3.30.420.150; Exopolyphosphatase. Domain 2; 1.
DR   InterPro; IPR000407; GDA1_CD39_NTPase.
DR   PANTHER; PTHR11782; ADENOSINE/GUANOSINE DIPHOSPHATASE; 1.
DR   PANTHER; PTHR11782:SF99; ECTONUCLEOSIDE TRIPHOSPHATE DIPHOSPHOHYDROLASE 6; 1.
DR   Pfam; PF01150; GDA1_CD39; 1.
DR   PROSITE; PS01238; GDA1_CD39_NTPASE; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|PIRSR:PIRSR600407-2};
KW   Hydrolase {ECO:0000256|RuleBase:RU003833};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Nucleotide-binding {ECO:0000256|PIRSR:PIRSR600407-2};
KW   Reference proteome {ECO:0000313|Proteomes:UP000248483};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        15..34
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   REGION          367..389
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        196
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR600407-1"
FT   BINDING         226..230
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR600407-2"
SQ   SEQUENCE   389 AA;  42560 MW;  DF4A32D5FB12BB58 CRC64;
     MRKVPNSGNL RVTKVAYPLG LFVCLFTCVA YIKWHWASAP RAFLGIPEVA TGARRGQQSR
     SPPGTAARGP EVFYGIMFDA GSTGTRVHVF QFSRQPGETP TLTHETFKAL KPGLSAYADD
     VDKSTPGIQE LLDIAKQNIP FEFWKATPLV LKATAGLRLL PGEKAQKLLR KVKEVFEASP
     FLVGDDCVSI MNGTDEGVSA WITVNFLTGS LKTPGRSNVG MLDLGGGSTQ ITFLPRFEGT
     LQTSPPGFLT SLQMFNRTYR LYSYSYLGLG LMSARLAVLG GEEGKPAEDG AELVSPCLSP
     GFRGEWEHAE VTYRVSGQEA GTRFPGKPPV REDLDVPRLR ADSQAWLWAW QLCGKWLLLP
     HPPPVLLRGR ERPQSPRPVS PTGSRGFVL
//