ID A0A2Y9PXX0_DELLE Unreviewed; 725 AA.
AC A0A2Y9PXX0;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Synaptic vesicle glycoprotein 2C {ECO:0000313|RefSeq:XP_022450330.1};
GN Name=SV2C {ECO:0000313|RefSeq:XP_022450330.1};
OS Delphinapterus leucas (Beluga whale).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Monodontidae; Delphinapterus.
OX NCBI_TaxID=9749 {ECO:0000313|Proteomes:UP000248483, ECO:0000313|RefSeq:XP_022450330.1};
RN [1] {ECO:0000313|RefSeq:XP_022450330.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022450330.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, synaptic
CC vesicle membrane {ECO:0000256|ARBA:ARBA00004644}; Multi-pass membrane
CC protein {ECO:0000256|ARBA:ARBA00004644}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC {ECO:0000256|ARBA:ARBA00008335}.
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DR RefSeq; XP_022450330.1; XM_022594622.1.
DR AlphaFoldDB; A0A2Y9PXX0; -.
DR STRING; 9749.A0A2Y9PXX0; -.
DR Ensembl; ENSDLET00000012349; ENSDLEP00000011188; ENSDLEG00000008107.
DR KEGG; dle:111185210; -.
DR InParanoid; A0A2Y9PXX0; -.
DR OrthoDB; 2615066at2759; -.
DR Proteomes; UP000248483; Unplaced.
DR GO; GO:0098691; C:dopaminergic synapse; IEA:Ensembl.
DR GO; GO:0030672; C:synaptic vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0007268; P:chemical synaptic transmission; IEA:InterPro.
DR GO; GO:0006836; P:neurotransmitter transport; IEA:UniProtKB-KW.
DR GO; GO:2000300; P:regulation of synaptic vesicle exocytosis; IEA:Ensembl.
DR CDD; cd17440; MFS_SV2C; 1.
DR Gene3D; 2.160.20.80; E3 ubiquitin-protein ligase SopA; 1.
DR Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 2.
DR InterPro; IPR001646; 5peptide_repeat.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR005828; MFS_sugar_transport-like.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR005829; Sugar_transporter_CS.
DR InterPro; IPR022308; SV2.
DR NCBIfam; TIGR01299; synapt_SV2; 1.
DR PANTHER; PTHR23511; SYNAPTIC VESICLE GLYCOPROTEIN 2; 1.
DR PANTHER; PTHR23511:SF6; SYNAPTIC VESICLE GLYCOPROTEIN 2C; 1.
DR Pfam; PF07690; MFS_1; 1.
DR Pfam; PF13599; Pentapeptide_4; 1.
DR Pfam; PF00083; Sugar_tr; 1.
DR SUPFAM; SSF103473; MFS general substrate transporter; 2.
DR SUPFAM; SSF141571; Pentapeptide repeat-like; 1.
DR PROSITE; PS50850; MFS; 1.
DR PROSITE; PS00217; SUGAR_TRANSPORT_2; 1.
PE 3: Inferred from homology;
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Neurotransmitter transport {ECO:0000256|ARBA:ARBA00022775};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000248483};
KW Synapse {ECO:0000256|ARBA:ARBA00023018};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022775}.
FT TRANSMEM 152..177
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 189..208
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 220..237
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 243..267
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 279..301
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 321..340
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 436..454
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 578..601
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 608..627
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 633..657
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 669..690
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 696..716
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 154..720
FT /note="Major facilitator superfamily (MFS) profile"
FT /evidence="ECO:0000259|PROSITE:PS50850"
FT REGION 24..85
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 24..51
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 725 AA; 81896 MW; EABA3C56AE04AFD0 CRC64;
MEDSYKDRTS LMKGAKDIAR EVKKQTVKKV NQAVDRAQDE YTQRSYSRFQ DEEDDDDYYP
PGETYNGEAN DDEGSSEATE GHDEDDEIYE GEYQGIPNMN QGKDSIVAVG QPKGNEYKDR
QELESERRAD EEELAQQYEL IIQECGHGRF QWALFFVLGM ALMADGVEVF VVGFVLPSAE
TDLCIPDSGS GWLGSIVYLG MMVGAFFWGG LADKVGRKQS LLICMSINGF FAFLSSFVQG
YGFFLFCRLL SGFGIGGAIP TVFSYFAEVL AREKRGEHLS WLCMFWMIGG IYASAMAWAI
IPHYGWSFNM GSAYEFHSWR VFIIVCALPC VCSVVALTFM PESPRFLLEV GKHDEAWMIL
KLIHDTNMRA RGQSEKVFTV NRIKTPRQID ELIEIESDTG TWYRRCFVRI RTELYGIWLT
FMSCFTYPVK DNTIKLTIVW FTLSFGYYGL SIWFPDVIKH LQSNVLKDVD DPTGQFSNLT
ANFTTANKIV SGLEWDNGRF EGIRLKSIIF KDSVFKSCTF EDVTSVNTYF KNCMFINTVF
NNTDFEPYKF INCEFQNCTF LHNKTGCYIT FEDDYGAYWI YFVNFLGTLA VLPGNIVSAL
LMDRIGRLTM LGGSMVLSGI SCFFLWFGTS ESMMIGMLCL YNGLTISAWN SLDVVTVELY
PTDRRATGFG FLNALCKAAA VLGNLIFGSL VSITKAIPIL LASTVLVCGG LVGLRLPDTR
TQVLM
//
