ID A0A2Y9PYS1_DELLE Unreviewed; 1968 AA.
AC A0A2Y9PYS1;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE SubName: Full=Myosin-7B isoform X3 {ECO:0000313|RefSeq:XP_022448298.1};
GN Name=MYH7B {ECO:0000313|RefSeq:XP_022448298.1};
OS Delphinapterus leucas (Beluga whale).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Monodontidae; Delphinapterus.
OX NCBI_TaxID=9749 {ECO:0000313|Proteomes:UP000248483, ECO:0000313|RefSeq:XP_022448298.1};
RN [1] {ECO:0000313|RefSeq:XP_022448298.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022448298.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, myofibril
CC {ECO:0000256|ARBA:ARBA00004657}.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Myosin family. {ECO:0000256|ARBA:ARBA00008314,
CC ECO:0000256|PROSITE-ProRule:PRU00782}.
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DR RefSeq; XP_022448298.1; XM_022592590.2.
DR Proteomes; UP000248483; Unplaced.
DR GO; GO:0030016; C:myofibril; IEA:UniProtKB-SubCell.
DR GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR GO; GO:0051015; F:actin filament binding; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003774; F:cytoskeletal motor activity; IEA:UniProtKB-UniRule.
DR CDD; cd14927; MYSc_Myh7b; 1.
DR Gene3D; 1.10.10.820; -; 1.
DR Gene3D; 1.20.5.340; -; 3.
DR Gene3D; 1.20.5.370; -; 4.
DR Gene3D; 1.20.5.4820; -; 1.
DR Gene3D; 1.20.58.530; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR Gene3D; 2.30.30.360; Myosin S1 fragment, N-terminal; 1.
DR Gene3D; 1.20.120.720; Myosin VI head, motor domain, U50 subdomain; 1.
DR Gene3D; 1.20.5.1160; Vasodilator-stimulated phosphoprotein; 1.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR001609; Myosin_head_motor_dom.
DR InterPro; IPR004009; Myosin_N.
DR InterPro; IPR008989; Myosin_S1_N.
DR InterPro; IPR002928; Myosin_tail.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014751; XRCC4-like_C.
DR PANTHER; PTHR45615; MYOSIN HEAVY CHAIN, NON-MUSCLE; 1.
DR PANTHER; PTHR45615:SF29; MYOSIN-7B; 1.
DR Pfam; PF00063; Myosin_head; 1.
DR Pfam; PF02736; Myosin_N; 1.
DR Pfam; PF01576; Myosin_tail_1; 1.
DR PRINTS; PR00193; MYOSINHEAVY.
DR SMART; SM00242; MYSc; 1.
DR SUPFAM; SSF90257; Myosin rod fragments; 5.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50096; IQ; 1.
DR PROSITE; PS51456; MYOSIN_MOTOR; 1.
DR PROSITE; PS51844; SH3_LIKE; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Methylation {ECO:0000256|ARBA:ARBA00022481};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Myosin {ECO:0000256|ARBA:ARBA00023123, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Reference proteome {ECO:0000313|Proteomes:UP000248483}.
FT DOMAIN 55..105
FT /note="Myosin N-terminal SH3-like"
FT /evidence="ECO:0000259|PROSITE:PS51844"
FT DOMAIN 109..809
FT /note="Myosin motor"
FT /evidence="ECO:0000259|PROSITE:PS51456"
FT REGION 686..708
FT /note="Actin-binding"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
FT COILED 873..1448
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1473..1588
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1618..1919
FT /evidence="ECO:0000256|SAM:Coils"
FT BINDING 202..209
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
SQ SEQUENCE 1968 AA; 223292 MW; 64B504F84D4E875A CRC64;
MVRVPAALDC LEPLRSHPPP LSATTMMDVS ELGESARYLR QGYQEQMKVH TVLWDGKKRV
WVPDEQDAYV EAEVKSEATG GRVNVETKDQ KVLTVREAEL QPMNPPRFDL LEDMTMMTHL
NEAAVLHNLR QRYARWMIYT YSGLFCVTIN PYKWLPIYTA SVVAAYKGKR RSEAPPHIYA
VADNAYNDML RNRENQSMLI TGESGAGKTV NTKRVIQYFA IVAALGDGLG KKAFLATKTR
GTLEDQIIEA NPAMEAFGNA KTLRNDNSSR FGKFIRIHFG PSGKLASADI DSYLLEKSRV
IFQLPGERGY HVYYQILSGK KPELQDMLLL SMNPYDYHFC SQGVITVDHM NDGEELMATD
HAMDILGFSV DEKCACYKVV GALLHFGNMK FKQKQRDEQA EADGTESADK AAYLMGVSSG
DLLKGLLHPR VRVGNEYVTK GQSVEQVVFA VGALAKATYD RLFRWLVSRI NQTLDTKLPR
QLFIGVLDIA GFEVFEFNSF EQLCINFTNE KLQQFFNQHM FVLEQEEYKR EGIDWVFIDF
GLDLQPCIDL IEKPLGILSI LEEECMFPKA SDASFQAKLY DNHAGKSPNF QQPRPDKKRK
YQAHFEVVHY AGVVPYSIVG WLEKNKDPLN ETVVPIFQKS QNKLLAALYE NYAGSSSTEP
PKSGVREKRR KAASFQTVSQ LHKENLNKLM TNLRATQPHF VRCIVPNENK TPGIMDAFLV
LHQLRCNGVL EGIRICRQGF PNRLLYADFR QRYRILNPSA IPDDTFMDSR KATEKLLASL
NIDHTQYQFG HTKVFFKAGL LGVLEELRDQ CLAKVLTLLQ ARSRGRLMRL EYQRLLGGRD
ALFTIQWNIR AFNAVKNWSW MKLFFKMKPL LRSAQAEAEL AALRAELRGL RGALATAEAK
CQELEETHVS VTQEKNDLAL QLQAEQENLV DAEERCHLLI KSKVQLEAKV KELSERLEDE
EEVNADLAAR RRKLEDECTE LKKDTDDLEL TLAKAEKEKQ ATESKVKNLT EEMVALDESV
ARLTKEKKAL QEAHQQALGD LQAEEDRVSA LAKAKARLEQ QVEDLECCLE QEKKLRMDME
RAKRKLEGDL KLTQESVTDA AQDKQQLEEK LQKKDSELSQ LNLRVEDEQL LGAQLQKKIR
ELQSRAEALE EELEAERSAR ARVEKQRAEA ARELAELSER LEEVGGVSAG QREGCRKHEA
ELGRLRRELE EVALRHEATV AALRRKQAES AAELGEQADS LQRARQKLEK EKSELRMEVD
DLGASVETLA RGKASAEKLC RAYEDQLSEA KIKVQELQRQ LADASTQQGR LQAESGKLSR
LLEEKESLIS QLSRGKALAT QSLEELRRQL EEESKAKSTL AHAVQASRHD CDLLREQHEE
EAEAQAELQR LLSKANAEVA QWRSKYEADA IQRTEELEEA KKKLALRLQE AEAGVEAAHA
KCSSLEKAKL RLQTESEDVT LELERATSAA TALDKKQRHL ERALEERRRQ EEEMQRELEA
AQREARSLGT ELFRLRHSHE EALEALEMLR RENKNLQEEV SDLTDQVSLS GKSIQELEKA
KKALEGEKSE LQAALEEAEG ALELEETKTL RTQLELSQVK AEVDRKLVEK DEEGADLRRN
HQRAVESLQA SLDAETRARN EALRLKKKME GDLNDLELQL GHATRQATEA QAATRLLQAQ
LKEEQAGRDE EQRLAAELHE QAQALERRAA LLAAELEELR AALEQAERSR RLAEQELLEA
TERLSLLHSQ NTGLLSQKKK LEVDLAQLSG EAEEAAQERR EAEEKAKKAI TDAAMMAEEL
QKEQDTSTHL EQMKKSLEQT VRELQARLEE AEQAALRGGK KQVQKLEAKV RELEAELDAE
QKQHAEALKG VRKHERRVKE LAYQAEEDRK NLARMQDLVD KLQSKVKSYK RQCEEAVSAR
GSEDACGHPT STAGPRLCSQ VGCQQPVRPA PSLGRGFPRV GLVRRLGQ
//
