ID A0A2Y9Q0B8_DELLE Unreviewed; 1281 AA.
AC A0A2Y9Q0B8;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Slit homolog 3 protein isoform X1 {ECO:0000313|RefSeq:XP_022450851.1};
GN Name=SLIT3 {ECO:0000313|RefSeq:XP_022450851.1};
OS Delphinapterus leucas (Beluga whale).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Monodontidae; Delphinapterus.
OX NCBI_TaxID=9749 {ECO:0000313|Proteomes:UP000248483, ECO:0000313|RefSeq:XP_022450851.1};
RN [1] {ECO:0000313|RefSeq:XP_022450851.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022450851.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR RefSeq; XP_022450851.1; XM_022595143.1.
DR KEGG; dle:111185491; -.
DR Proteomes; UP000248483; Unplaced.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0016043; P:cellular component organization; IEA:UniProt.
DR GO; GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
DR CDD; cd00054; EGF_CA; 5.
DR CDD; cd00110; LamG; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 2.10.25.10; Laminin; 9.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 3.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR006207; Cys_knot_C.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR001791; Laminin_G.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000372; LRRNT.
DR PANTHER; PTHR45836; SLIT HOMOLOG; 1.
DR PANTHER; PTHR45836:SF9; SLIT HOMOLOG 3 PROTEIN; 1.
DR Pfam; PF00008; EGF; 5.
DR Pfam; PF12661; hEGF; 2.
DR Pfam; PF02210; Laminin_G_2; 1.
DR Pfam; PF13855; LRR_8; 3.
DR Pfam; PF01463; LRRCT; 4.
DR Pfam; PF01462; LRRNT; 2.
DR SMART; SM00041; CT; 1.
DR SMART; SM00181; EGF; 9.
DR SMART; SM00179; EGF_CA; 8.
DR SMART; SM00282; LamG; 1.
DR SMART; SM00365; LRR_SD22; 6.
DR SMART; SM00369; LRR_TYP; 12.
DR SMART; SM00082; LRRCT; 3.
DR SMART; SM00013; LRRNT; 3.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 5.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR SUPFAM; SSF52058; L domain-like; 3.
DR PROSITE; PS00010; ASX_HYDROXYL; 2.
DR PROSITE; PS01185; CTCK_1; 1.
DR PROSITE; PS01225; CTCK_2; 1.
DR PROSITE; PS00022; EGF_1; 9.
DR PROSITE; PS01186; EGF_2; 8.
DR PROSITE; PS50026; EGF_3; 8.
DR PROSITE; PS01187; EGF_CA; 2.
DR PROSITE; PS50025; LAM_G_DOMAIN; 1.
DR PROSITE; PS51450; LRR; 3.
PE 4: Predicted;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Reference proteome {ECO:0000313|Proteomes:UP000248483};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 676..711
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 713..752
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 754..790
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 792..830
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 832..868
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 877..913
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 916..1090
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 1126..1161
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1166..1202
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1207..1281
FT /note="CTCK"
FT /evidence="ECO:0000259|PROSITE:PS01225"
FT DISULFID 701..710
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 742..751
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 780..789
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 820..829
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 858..867
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 903..912
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1063..1090
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00122"
FT DISULFID 1130..1140
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1151..1160
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1170..1180
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1192..1201
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 1281 AA; 140402 MW; 705078B252D562C1 CRC64;
MAPVHLRGFN VADVQKKEYV CPGPHSEPPS CNANSISCPS ACTCSNNIVD CRGKGLMEIP
ANLPEGIVEI RLEQNSIKSI PAGAFTQYKK LKRIDISKNQ ISDIAPDAFQ GLKSLTSLVL
YGNKITEIAK GLFDGLVSLQ LLLLNANKIN CLRVNTFQDL QNLNLLSLYD NKLQTVSKGL
FAPLQAIQTL HLAQNPFVCD CHLKWLADYL QDNPIETSGA RCSSPRRLAN KRIGQIKSKK
FRCSGSEDYR SRFSSECFMD LVCPDRCRCE GTIVDCSNQK LARVPSHLPE YVTDLRLNDN
EISVLEATGI FKKLPNLRKI NLSNNRIKEV REGAFDGAAS LQELMLTGNQ LETVHGRVFR
GLSGLKTLML RSNLISCVSN DTFAGLSSVR LLSLYDNRIT TITPGAFTTL VSLSTINLLS
NPFNCNCHLA WLGKWLRKRR IVSGNPRCQK PFFLKEIPIQ DVAIQDFTCE GNDESSCRLG
PRCPEQCTCM ETVVRCSNKG LRTLPKGIPK DVTELYLEGN HLTAVPKELP TLRHLTLIDL
SNNSIGMLTN YTFSNMSHLS TLILSYNRLR CIPIHSFNGL RSLRVLTLHG NDISSVPEGS
FNDLTSLSHL ALGTNPLHCD CSLRWLSEWV KAGYKEPGIA RCSSPEPMAD RLLLTTPTHR
FQCKGPVDIN IVAKCNACLS SPCKNNGTCS RDPVEQYRCA CPYGYKGKDC TVPINTCLQN
PCLHGGTCHL SESHSDGFSC SCPLGFEGQR CEINPDDCED SDCENNATCV DGINTYVCVC
PPDYTGELCD EVIDHCVPGM NLCQHEAKCV SLDRGFRCEC LPGYSGKLCE VNSDDCAAHR
CRHGAQCVDA VNGYTCICPQ GFSGLYCEHP PPMVLLQTSP CDQYECQNGA QCIVVQQEPT
CRCPPGFAGP RCEKLITVNF VGKDSYVELA SAKVRPQANI SLQVATDKDN GILLYKGDND
PLALELYQGH VRLIYDSLSS PPTTVYSVET VNDGQFHSVE LVMLNQTLNL VVDKGAPKSL
GKLQKQPTVG INSPLYLGGI PTSTGLSALR QGVDRPLGGF HGCIHEVRIN NELQDFKALP
PQALGVSPGC KSCSVCRHGL CRAVEKDSVV CECHPGWTGL LCDQEARDPC LGHSCSQGRC
VATGTSYVCK CAEGYRGALC DHKNDSANAC SAFKCHHGQC HVSDQGEPYC LCQPGFSGEH
CEQETPCLGG VVREVIRRQK GYASCATASK VPLMECHGGC GPQCCQPTRS KRRKYVFQCT
DGSSFVEEVE RHLECGCRPC S
//
