ID   A0A2Y9Q2C8_DELLE        Unreviewed;       828 AA.
AC   A0A2Y9Q2C8;
DT   12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT   12-SEP-2018, sequence version 1.
DT   27-MAR-2024, entry version 21.
DE   SubName: Full=Disks large homolog 2 isoform X16 {ECO:0000313|RefSeq:XP_022449692.1};
GN   Name=DLG2 {ECO:0000313|RefSeq:XP_022449692.1};
OS   Delphinapterus leucas (Beluga whale).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC   Monodontidae; Delphinapterus.
OX   NCBI_TaxID=9749 {ECO:0000313|Proteomes:UP000248483, ECO:0000313|RefSeq:XP_022449692.1};
RN   [1] {ECO:0000313|RefSeq:XP_022449692.1}
RP   IDENTIFICATION.
RC   TISSUE=Blood {ECO:0000313|RefSeq:XP_022449692.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   RefSeq; XP_022449692.1; XM_022593984.1.
DR   AlphaFoldDB; A0A2Y9Q2C8; -.
DR   Proteomes; UP000248483; Unplaced.
DR   GO; GO:0031594; C:neuromuscular junction; IEA:InterPro.
DR   GO; GO:0043005; C:neuron projection; IEA:InterPro.
DR   GO; GO:0019900; F:kinase binding; IEA:InterPro.
DR   GO; GO:0007268; P:chemical synaptic transmission; IEA:InterPro.
DR   CDD; cd00071; GMPK; 1.
DR   CDD; cd00992; PDZ_signaling; 3.
DR   CDD; cd12032; SH3_DLG2; 1.
DR   Gene3D; 2.30.42.10; -; 3.
DR   Gene3D; 3.30.63.10; Guanylate Kinase phosphate binding domain; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   Gene3D; 2.30.30.40; SH3 Domains; 2.
DR   InterPro; IPR019583; DLG1-4_PDZ_assoc.
DR   InterPro; IPR016313; DLG1-like.
DR   InterPro; IPR019590; DLG1_PEST_dom.
DR   InterPro; IPR035759; DLG2_SH3.
DR   InterPro; IPR008145; GK/Ca_channel_bsu.
DR   InterPro; IPR008144; Guanylate_kin-like_dom.
DR   InterPro; IPR020590; Guanylate_kinase_CS.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR001478; PDZ.
DR   InterPro; IPR036034; PDZ_sf.
DR   InterPro; IPR036028; SH3-like_dom_sf.
DR   InterPro; IPR001452; SH3_domain.
DR   PANTHER; PTHR23119; DISCS LARGE; 1.
DR   PANTHER; PTHR23119:SF6; DISKS LARGE HOMOLOG 2; 1.
DR   Pfam; PF00625; Guanylate_kin; 1.
DR   Pfam; PF10608; MAGUK_N_PEST; 1.
DR   Pfam; PF00595; PDZ; 3.
DR   Pfam; PF10600; PDZ_assoc; 1.
DR   Pfam; PF00018; SH3_1; 1.
DR   PIRSF; PIRSF001741; MAGUK_DLGH; 1.
DR   SMART; SM00072; GuKc; 1.
DR   SMART; SM00228; PDZ; 3.
DR   SMART; SM00326; SH3; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF50156; PDZ domain-like; 3.
DR   SUPFAM; SSF50044; SH3-domain; 1.
DR   PROSITE; PS00856; GUANYLATE_KINASE_1; 1.
DR   PROSITE; PS50052; GUANYLATE_KINASE_2; 1.
DR   PROSITE; PS50106; PDZ; 3.
DR   PROSITE; PS50002; SH3; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000248483};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW   ProRule:PRU00192}.
FT   DOMAIN          56..143
FT                   /note="PDZ"
FT                   /evidence="ECO:0000259|PROSITE:PS50106"
FT   DOMAIN          151..238
FT                   /note="PDZ"
FT                   /evidence="ECO:0000259|PROSITE:PS50106"
FT   DOMAIN          379..460
FT                   /note="PDZ"
FT                   /evidence="ECO:0000259|PROSITE:PS50106"
FT   DOMAIN          494..564
FT                   /note="SH3"
FT                   /evidence="ECO:0000259|PROSITE:PS50002"
FT   DOMAIN          638..813
FT                   /note="Guanylate kinase-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50052"
SQ   SEQUENCE   828 AA;  92639 MW;  B3B40B911D322C95 CRC64;
     MFASIWYAKK LGRRFVHNAR KAKSEKASPA PIIVNTDTLD TIPYVNGTEI EYEFEEITLE
     RGNSGLGFSI AGGTDNPHIG DDPGIFITKI IPGGAAAEDG RLRVNDCILR VNEVDVSEVS
     HSKAVEALKE AGSIVRLYVR RRRPILETVV EIKLFKGPKG LGFSIAGGVG NQHIPGDNSI
     YVTKIIDGGA AQKDGRLQVG DRLLMVNNYS LEEVTHEEAV AILKNTSDVV YLKVGKATTI
     YMTDPYGPPD ITHPYSPPMG NHLLSGNNGT LEYKTSLPPI SPGRYSPIPK HMLVEDDYTR
     PPEPVYSTVN KLCDKPASPR HYSPVECDKS FLLSAPYPHY HLGLLPDSEM TSHSQHSTTT
     RQPSVTLQRA ISLEGEPRKV VLHKGSTGLG FNIVGGEDGE GIFVSFILAG GPADLSGELQ
     RGDQILSVNG IDLRGASHEQ AAAALKGAGQ TVTIIAQYQP EDYARFEAKI HDLREQMMNH
     SMSSGSGSLR TNQKRSLYVR AMFDYDKSKD SGLPSQGLSF KYGDILHVIN ASDDEWWQAR
     RVTLEGDSEE MGVIPSKRRV ERKERARLKT VKFNAKPGVI DSKGSFNDKR KKSFIFSRKF
     PFYKNKEQSE QETSDPERGQ EDFILSYEPV TRQEINYTRP VIILGPMKDR INDDLISEFP
     DKFGSCVPHT TRPKRDYEVD GRDYHFVISR EQMEKDIQEH KFIEAGQYND NLYGTSVQSV
     RFVAERGKHC ILDVSGNAIK RLQVAQLYPI AIFIKPKSLE PLMEMNKRLT EEQAKKTYDR
     AIKLEQEFGE YFTAIVQGDT LEDIYNQCKL VIEEQSGPFI WIPSKEKL
//