ID A0A2Y9Q6D2_DELLE Unreviewed; 830 AA.
AC A0A2Y9Q6D2;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 10-FEB-2021, sequence version 2.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=Solute carrier organic anion transporter family member {ECO:0000256|RuleBase:RU362056};
GN Name=SLCO4A1 {ECO:0000313|RefSeq:XP_022453165.2};
OS Delphinapterus leucas (Beluga whale).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Monodontidae; Delphinapterus.
OX NCBI_TaxID=9749 {ECO:0000313|Proteomes:UP000248483, ECO:0000313|RefSeq:XP_022453165.2};
RN [1] {ECO:0000313|RefSeq:XP_022453165.2}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022453165.2};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU362056};
CC Multi-pass membrane protein {ECO:0000256|RuleBase:RU362056}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the organo anion transporter (TC 2.A.60) family.
CC {ECO:0000256|ARBA:ARBA00009657, ECO:0000256|RuleBase:RU362056}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU362056}.
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DR RefSeq; XP_022453165.2; XM_022597457.2.
DR AlphaFoldDB; A0A2Y9Q6D2; -.
DR Proteomes; UP000248483; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0006811; P:monoatomic ion transport; IEA:UniProtKB-KW.
DR GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 1.
DR InterPro; IPR002350; Kazal_dom.
DR InterPro; IPR036058; Kazal_dom_sf.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR004156; OATP.
DR NCBIfam; TIGR00805; oat; 1.
DR PANTHER; PTHR11388; ORGANIC ANION TRANSPORTER; 1.
DR PANTHER; PTHR11388:SF100; SOLUTE CARRIER ORGANIC ANION TRANSPORTER FAMILY MEMBER 4A1; 1.
DR Pfam; PF07648; Kazal_2; 1.
DR Pfam; PF03137; OATP; 2.
DR SUPFAM; SSF100895; Kazal-type serine protease inhibitors; 1.
DR SUPFAM; SSF103473; MFS general substrate transporter; 1.
DR PROSITE; PS51465; KAZAL_2; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Ion transport {ECO:0000256|RuleBase:RU362056};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362056};
KW Reference proteome {ECO:0000313|Proteomes:UP000248483};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU362056};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU362056}; Transport {ECO:0000256|RuleBase:RU362056}.
FT TRANSMEM 172..191
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 211..232
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 239..259
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 295..319
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 331..357
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 377..398
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 452..472
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 492..512
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 524..542
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 767..790
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT DOMAIN 565..619
FT /note="Kazal-like"
FT /evidence="ECO:0000259|PROSITE:PS51465"
FT REGION 40..59
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 105..134
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 608..659
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 800..830
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 105..126
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 612..629
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 830 AA; 88284 MW; 9DC9939D9C8CC705 CRC64;
MKLEWALSGS QSLVRSAAAG SSGRSTLSSV ASFRPGAALT RLGSGQAEPS VPPGTGRGRV
LLEMDSSRRS DRRWNSASTP AAIAVTPSEM PQLVFPGPPL ATNSECDCTP PSRRASLGSP
LSQPLCQPQP EKHGPQAARE VRYVATGRPD EACGWRAFAP TCLQAFNTPR GFLLFLCAAS
FLQGMTVNGF INTVITSIER RYDLHSYHSG LIASSYDVAA CLCLTFVGYF GGHGHKPRWL
GWGVLVMGAG SLVFSLPHFT TGPYEVQVDE AVGTCRANHS TTCRGHASGL SSYQLVFMLG
QFLHGVGATP LYTLGVTYLD ENVKSSYSPV YIAIFYTAAI LGPAAGYLVG GALLNIYTEI
GQRTELTTES PLWVGAWWVG FLGTGVAAFL IAMPILGYPR QLPGSQRYVV MRASDTHQLK
DSSHRVTSNP DFGKTIRDLP LSIWLLLKNP TFILLCLAGA TEATLIAGMS TFGPKFLESQ
FSLSASEAAT LFGYLVVPAG GGGTFLGGFF VNKCKLRGSG IVRFCLLCSL TSMLAFLVFF
THCPNVPMAG VTASYNGSLL PEGHLGLTDA CNAACGCQPE HYSPVCGPDG LMYYSPCHAG
CPEAASPGPG GQKQRPCTNG NSTVSPGPRS LRPRTFPLQP RRSSADPCGG RAGPPESCGR
RALTASVRCL PPGDAARGSA RTRPLAWGVT WPRFPGVDAP VFHYRCVCDQ QRSFALGIQW
IVVRTLGGIP GPIAFGWVID KACLLWQTQC GQQGSCFVYQ NSAMSQYLLI AGLAYKVLGF
IFFTTACFLY KPLSGSSDGL EASLPSQSSA SDNPTDLQEA PSALQIQSDI
//
