ID A0A2Y9Q7F2_DELLE Unreviewed; 439 AA.
AC A0A2Y9Q7F2;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE RecName: Full=P2X purinoceptor {ECO:0000256|RuleBase:RU000681};
GN Name=P2RX7 {ECO:0000313|RefSeq:XP_022453530.1};
OS Delphinapterus leucas (Beluga whale).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Monodontidae; Delphinapterus.
OX NCBI_TaxID=9749 {ECO:0000313|Proteomes:UP000248483, ECO:0000313|RefSeq:XP_022453530.1};
RN [1] {ECO:0000313|RefSeq:XP_022453530.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022453530.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Receptor for ATP that acts as a ligand-gated ion channel.
CC {ECO:0000256|RuleBase:RU000681}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU000681}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU000681}.
CC -!- SIMILARITY: Belongs to the P2X receptor family.
CC {ECO:0000256|ARBA:ARBA00009848, ECO:0000256|RuleBase:RU000681}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU000681}.
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DR RefSeq; XP_022453530.1; XM_022597822.2.
DR AlphaFoldDB; A0A2Y9Q7F2; -.
DR Proteomes; UP000248483; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR GO; GO:0098794; C:postsynapse; IEA:GOC.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004931; F:extracellularly ATP-gated monoatomic cation channel activity; IEA:InterPro.
DR GO; GO:0001614; F:purinergic nucleotide receptor activity; IEA:InterPro.
DR GO; GO:0033198; P:response to ATP; IEA:InterPro.
DR Gene3D; 1.10.287.940; atp-gated p2x4 ion channel; 1.
DR Gene3D; 2.60.490.10; atp-gated p2x4 ion channel domain; 1.
DR InterPro; IPR046815; P2RX7_C.
DR InterPro; IPR003050; P2X7_purinoceptor.
DR InterPro; IPR027309; P2X_extracellular_dom_sf.
DR InterPro; IPR001429; P2X_purnocptor.
DR NCBIfam; TIGR00863; P2X; 1.
DR PANTHER; PTHR10125; P2X PURINOCEPTOR; 1.
DR PANTHER; PTHR10125:SF13; P2X PURINOCEPTOR 7; 1.
DR Pfam; PF20478; P2RX7_C; 1.
DR Pfam; PF00864; P2X_receptor; 1.
DR PRINTS; PR01314; P2X7RECEPTOR.
DR PRINTS; PR01307; P2XRECEPTOR.
DR PROSITE; PS01212; P2X_RECEPTOR; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Ion channel {ECO:0000256|RuleBase:RU000681};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU000681};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU000681};
KW Receptor {ECO:0000256|RuleBase:RU000681};
KW Reference proteome {ECO:0000313|Proteomes:UP000248483};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000681};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU000681};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU000681}.
FT TRANSMEM 333..355
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU000681"
FT DOMAIN 400..432
FT /note="P2X purinoreceptor 7 intracellular"
FT /evidence="ECO:0000259|Pfam:PF20478"
SQ SEQUENCE 439 AA; 50867 MW; F0EF8426C4187C02 CRC64;
MTACCSWNDV FQYETNKVIR IQSTNYGTIK WFFHVLFFSY ISFALVNDRL YQWKEPVISS
VHAKVKGVAK VKKEIMENGL KKVVWNVFDT ADYTVPLQGN SFFVMTNFLK IEGQEQGLCP
EYPTRRTLCT SDQGCKKGWM GPKSKGIQTG RCIEYKGKQK TCEVSAWCPV EAAEKAPEPA
LLGSAENFTV LIKNNIDFPS HNYTTRNILP DINVTCTFHK TQNPQCPIFR LGDIFQETGD
NFSDVAIQGG IMGIEIYWDC NLDRWFHHCR PKYNFRRLDN KTAKESLYPG YSFRYAKYYK
ENNTEKRTLI KAFGIRFDIL VFGTGGKFDI IQLIVYIGSN LSYFGLGTVF IDFLINTYSN
KCCRSRIYPC CKCCEPCAVN EYYYRKKCES IVEPKQTLKY VSFVDEPHIR MVNQRLLERS
LQDVEGEEVP VYVTKNRQK
//
