ID A0A2Y9Q7K2_DELLE Unreviewed; 4506 AA.
AC A0A2Y9Q7K2;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Dynein heavy chain 2, axonemal {ECO:0000313|RefSeq:XP_022451443.1};
GN Name=DNAH2 {ECO:0000313|RefSeq:XP_022451443.1};
OS Delphinapterus leucas (Beluga whale).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Monodontidae; Delphinapterus.
OX NCBI_TaxID=9749 {ECO:0000313|Proteomes:UP000248483, ECO:0000313|RefSeq:XP_022451443.1};
RN [1] {ECO:0000313|RefSeq:XP_022451443.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022451443.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the dynein heavy chain family.
CC {ECO:0000256|ARBA:ARBA00008887}.
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DR RefSeq; XP_022451443.1; XM_022595735.2.
DR STRING; 9749.A0A2Y9Q7K2; -.
DR KEGG; dle:111185804; -.
DR InParanoid; A0A2Y9Q7K2; -.
DR OrthoDB; 166463at2759; -.
DR Proteomes; UP000248483; Unplaced.
DR GO; GO:0005930; C:axoneme; IEA:UniProt.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0031514; C:motile cilium; IEA:UniProt.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR CDD; cd00009; AAA; 1.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR041589; DNAH3_AAA_lid_1.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR013594; Dynein_heavy_tail.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR45703; DYNEIN HEAVY CHAIN; 1.
DR PANTHER; PTHR45703:SF32; DYNEINS HEAVY CHAIN; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF17857; AAA_lid_1; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08385; DHC_N1; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Cilium {ECO:0000256|ARBA:ARBA00023069};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000248483}.
FT DOMAIN 1876..2012
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2487..2634
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 32..55
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 3093..3127
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3299..3361
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3613..3647
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 4506 AA; 516908 MW; 4EC99B6D0DDEF43C CRC64;
MSSKADKKQE VSSRGSTRWR VAQSALAVQA VETTLPASSE SQAEPESLKE EPEPILEEPE
IQKEELQECE VDVKPLFLSR AVLTGLAAAT WTEEHDTILE HFAQDPSEPI LTIFIDPCLG
LKLGLGMPVQ TQNQIVYFIR QAQVPITPEN FEATVHFGTV RGSYIPALLR LLNGVFAPQI
FRNTTWPESI RNHFASHLHR FLACLTDTRY KLEGHTVLYI PTEAMNMKPE AVVKDKDLVQ
RLETSMIHWT RQIKEVLSAQ ETVETGENLG PLEEIEFWRN RCMDLSGISK QLVKPGVKHI
ESILRLAKSS YLAPFMKLAQ QIQDGSRQAQ SNLTFLSILK EPYQELAFMR PKDISSKLPR
LISLIRIIWV NSPHYNTRER LTSLFRKMSN EIIRLCCHAI SLDRIFEGYV ISSKEDLQGC
ISCCHAWRDH YLQAVQMHTQ FSRWGWVLDQ TSIFAQVDAF VQRCKDLIEV CDCQFHFARW
EDGKQGPLPC FSGAQGPQIT RNLLEIEDIF HKNLHVLRAV RGGILDVKNT SWHEDYNRFR
AGVKDLEVMT QNLISSAFEL VRDVEHGVLL LDTFRRLAAR ETIKRTYDKK AVDLYMLFNS
ELALVNRELS KKWPYLEPYM AQHSGQAHWV RILRRRIDRV MNCLSNAHFL PHIGTGEESV
HTYQQMVQAI DELVRKTFQD WTSTLDKDCI RRLDTPLLRI SQEKAGMLDV NFDKSLLILF
VEVDYWERLL FETPHYVVNV AERAEDLRIL RENLLLLARD YNRIIAMLSP DEQALFKERI
RFLDKKIHPG LKKLHWALQG ASAIFITECR VHASKVQTIV NEFKVSTLTI GWRAQVMSET
LLVRISGKRV YRDLEFEEDQ REHRAAVQQK LVSLHHDVVA IMTNSYEVFK NDGPEIQQQW
LQYTIRLDRM MEDALRLNVK WSLLELSKAI NGDGKTTPNP LFQVLVILKN DMQGAVAQVE
FSPTLQTLAS VVNDTGNHLF STISVFCHLP EILIKCKFLR EPIYTIVERD EDIKKIQAQI
SSGMTNNAAL LQNYLKTWDM YREIWEINKD SFIRRYQRLN PPVSSFDADI ARYTEVANNV
QKEETVLNIQ FVLLDCSHLK FSLVQHCSEW QNKFTTLLKE MAARRLLELH TYLQENAEKI
SHPPQTLEEL GVSLHLMETL QLEMPNLETQ IPPIHEQFTI LEKYEVPVQD SVLGMLDSLS
GQWVAFQQAV LDSEQMLKRH KEKFKTGLIH SADDFKKKTH NLLEEFEFKG PFASNVGHQA
ALGQIAHVRA VLNTMREEEN NLHANLGIFK IEQPASKDLQ NLEKELDALQ QVWEITRDWE
ENWNQWKTGR FLTLQTEAME TMAHGLFRRL TRLAKEYKDR NWEIIETTRS KIEQFKRTMP
LISDLRNPAL RERHWDQVRD EVQREFDQES ESFTLEQIVE LGMDQHVEKI GEISASATRA
LALELALQNI AKTWDVIQLD IVPYKDKGHH RLRGTEEVFQ ALEDNQVALS TMKASRFVKA
FEKDVDHWER CLSLILEVIE VVLTVQRQWM YLENIFLGED IRKQLPNESG LFDQVNGNWK
DIMGRMNKDP NALRSTHYPG LLDTLIEMNT ILEDIQKSLD MYLETKRHIF PRFYFLSNDD
LLEILGQSRN PEAVQPHLKK CFDNIKLLRM QKVGGPSSKW EAVGMFSGDG EYVDFLHSVL
LEGPVESWLG DVERTMRVTL RDLLRNCRLA LKKFLNKRDK WVKEWAGQVV ITASQIQWTA
DVTTCLLTAK ERGDKKILKV MKKKQVSILS KYSEAIRGNL TKIMRLKIVA LVTIEVHARD
VLEKLYKSGL MDVSSFDWLS QLRFYWEKDL DDCMIRQTNT QFQYGYEYLG NSGRLVITPL
TDRCYMTLTT ALHLHRGGSP KGPAGTGKTE TVKDLGKALG IYVIVVNCSE GLDYKSMGRM
YSGLAQMGAW GCFDEFNRIN VEVLSVVAQQ ILSILSALAA GLTRFYFEGF EINLVWSCGI
FITMNPGYAG RTELPDNLKS MFRPVAMVVP DATLIAEIIL FGEGFGNCKI LAKKVYTLYS
LAMQQLSRQD HYDFGLRALT SLLHCAGKKR RLQPDLSDEE VLLLSMRDMN IAKLTSVDVP
LFNAIVQDLF PSIELPVIDY GKLRETIEQE IRDMGLQTIP FTLTKVIQLY ETKNSRHSTM
IVGCTGSGKT ASWRILQSSL SSLCRAGEPN FNIVREFPLN PKALSLGELY GEYDLNTNEW
TDGVLSSVMR TACADEKPDE KWILFDGPVD TLWIESMNSV MDDNKVLTLI NGERIAMPEQ
VSLLFEVENL AVASPATVSR CGVVYTDYAD LGWKPYVQSW LEKRPKVEAE PLQRMFEKFI
NKMLTFKKNN CHELVPLPEY SGIISLCDLY SALATPENGV NPADGENFVS MVELTFVFSM
IWSVCASVDE EGRKKIDSYL REIEGTFPNK DTVYEYFVDP KMRSWTSFEE KLPKSWRYPP
NFPFYKIMVP TVDTVRYNYL VSTLVANQNP VLLVGPVGTG KTSIAQSVLQ SLPSSQWSVL
TVNMSAQTTS NNVQSIIESR VEKRTKGVYV PFGGKSMITF MDDLNMPAKD TFGSQPPLEL
IRLWIDYGFW YDRTKQTIKY IRDMFLMAAM GPSGGGRTVI SPRLQSRFNI INMTFPTESQ
IIRIFGTMIN QKLQDFEEEV KPTGDVVTKA TLDVYNTVVQ RFLPTPAKIH YLFNLRDISK
VFQGMLRASK DFHDTKFSIT RLWIHECFRV FSDRLVDTAD MEAFVGIISD KLGSFFDLTF
HNLCPNKRSP IFGDFLREPK VYEDLTDLTV LRTAMETALN EYNLSPAVVP MQLVLFREAI
EHITRIVRVI GQPRGNMLLV GIGGSGRQSL ARLASAICEY ITFQIEVTKH YRKQEFRDDI
KRLYRQAGVE LKATSFLFVD TQVADESFLE DINNILSSGE VPNLYKVDEF EEIQTHIIEQ
ARAEQVSESS DSLFAYFTER VRNNLHIILC LSPVGDPFRN WIRQYPALVN CTTINWFSEW
PREALLEVAE KYLVGADLGT QENIHRKVAQ IFVTMHWSVA QYSQKMLLEL RRHNYVTPTN
YLELVSGYKN LLAEKQQELL DQANKLRTGL FKIDETREKV EVMSLELEDA KKKVAEFQKQ
CEEYLVIIVQ QKREADEQQK AVTANSEKIA IEEVKCQALA DNAQKDLEEA LPALEEAMRA
LESLNKKDIG EIKSYGRPPA QVEMVLQAVM ILRGNEPTWA EAKRQLGEQN FIKSLINFDK
DNISDKVLKK IGAYCAQPDF QPDIIGRVSL AAKSLCMWVR AMELYGRLYR VVEPKRIRMN
TALAQLQEKQ AALAEAQEKL REVAGKLEML KKQYDEKLAQ KEELRKKSEE MEVKLERAGM
LVSGLAGEKA RWEEMVKGLE GDLGYLVGDC LLAAAFLSYM GPFLTNYRDE VVNQIWIRKI
SELQVPCSPH FTFDKFLSNP TKVRDWNLQG LPSDAFSTEN GIIVTRSNRW ALMIDPQAQA
LKWIKNMEGS QGLQIIDLQM SDYLRVLEKA IQFGHPVLLQ NVQEYLDPTL NPVLNKSVAR
TGGRLMMRIG DKEVEYNTSF RFYITTKLSN PHYGPETSAK TTIVNFAVKE QGLEAQLLGV
VVRKERPELE EQKDSLVVNI AAGKRQLEEL EDEILRLLNE ATGSLLDDVQ LVNTLRTSKI
TATEVTKQLE TSETTEINID LAREAYRPCA QRASVLFFVL NDMGRIDPMY QFSLDAYISL
FILSIDKSRR SNTLQDRIDH LNECHTYAVY RYTCRTLFER HKLLFSFQMC AKILETSGKL
NMDEYNFFLR GGVVLDREGQ MDNPCTSWLA DAYWDNITEL DKLTNFHGLM NSFEQYPRDW
NLWYTNATPE KAMLPGEWEN ACNEMQRMLI VRSLRQDRVA SCVTSFIVSN LGSRFTEPPV
LNMKLVMEDS APRTPLIFIL SPGVDPTSTL LQLAEHTGMA QRFHALSLGQ GQAPIAARLL
REGVVQGHWV FLANCHLSLS WMPNLDKLVE QLQVEDPHPS FRLWLSSSPH PDFPISILQA
SIKMTTEPPK GLKANMTRLY QLMTEPQFSR CSKPSKYKKL LFALCFFHSV LLERRKFLQL
GWNIICGFND SDFEVSENLL SLYLDEYEET PWDALKYLIA GVNYGGHVTD DWDRRLLTTY
INDYFCEQAL STPSYRLSVL ETYFIPKDGS LASYKEYISM LPCMDPPEIF GQHPNADVAS
QITEAHTLFE TLLSLQPQIT PTRAGDQSRE EKVLELAADV KQKIPEMIDY EGTRKLLAMD
PSPLNVVLLQ EIQRYNKLLE TILFSLTDLE KGIQGLIVMS TSLEEVFSCI FDARVPPLWG
KAYPSQKPLA SWTRDLAMRV EQFELWASRT RPPVIFWLPG FTFPTGFLTA VLQSSARQNN
ISVDSLSWEF IVSTVDDSNL VYPPKDGVWV RGLYLEGAGW DRKNSCLVEA EPMQLVCLMP
TIHFRPTESR KKSAKGMYSC PCYYYPNRAG SSDRASFVIG IDLRSGTMTS DHWIKRGTAL
LMSLDN
//
