ID A0A2Y9Q946_DELLE Unreviewed; 776 AA.
AC A0A2Y9Q946;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=Myotubularin-related protein 12 {ECO:0000256|ARBA:ARBA00018495};
DE AltName: Full=Inactive phosphatidylinositol 3-phosphatase 12 {ECO:0000256|ARBA:ARBA00033343};
GN Name=MTMR12 {ECO:0000313|RefSeq:XP_022455584.1};
OS Delphinapterus leucas (Beluga whale).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Monodontidae; Delphinapterus.
OX NCBI_TaxID=9749 {ECO:0000313|Proteomes:UP000248483, ECO:0000313|RefSeq:XP_022455584.1};
RN [1] {ECO:0000313|RefSeq:XP_022455584.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022455584.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, myofibril, sarcomere
CC {ECO:0000256|ARBA:ARBA00004204}. Sarcoplasmic reticulum
CC {ECO:0000256|ARBA:ARBA00004369}.
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family. Non-
CC receptor class myotubularin subfamily. {ECO:0000256|ARBA:ARBA00007471}.
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DR RefSeq; XP_022455584.1; XM_022599876.1.
DR AlphaFoldDB; A0A2Y9Q946; -.
DR STRING; 9749.A0A2Y9Q946; -.
DR InParanoid; A0A2Y9Q946; -.
DR OrthoDB; 5474662at2759; -.
DR Proteomes; UP000248483; Unplaced.
DR GO; GO:0030017; C:sarcomere; IEA:UniProtKB-SubCell.
DR GO; GO:0016529; C:sarcoplasmic reticulum; IEA:UniProtKB-SubCell.
DR CDD; cd14594; PTP-MTMR12; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR022587; MTMR12-like_C.
DR InterPro; IPR030576; MTMR12_PTP.
DR InterPro; IPR010569; Myotubularin-like_Pase_dom.
DR InterPro; IPR030564; Myotubularin_fam.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR PANTHER; PTHR10807; MYOTUBULARIN-RELATED; 1.
DR PANTHER; PTHR10807:SF37; MYOTUBULARIN-RELATED PROTEIN 12; 1.
DR Pfam; PF12578; 3-PAP; 1.
DR Pfam; PF06602; Myotub-related; 1.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS51339; PPASE_MYOTUBULARIN; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000248483};
KW Sarcoplasmic reticulum {ECO:0000256|ARBA:ARBA00022951}.
FT DOMAIN 234..672
FT /note="Myotubularin phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS51339"
FT COILED 690..720
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 776 AA; 88576 MW; ABABE5F1FAD1FEA0 CRC64;
MGGAPAASAG GRCERPPLLP GVAASQGGGM LGKGVVGGGG GTKAPKPSFV SYVRPEEIHT
NEKEVTEKEV TLHLLPGEQL LCEASTVLKC VQEDSCQRGI YGRLVCTDFK IAFLGDDESA
LDNDETQFKN KVIGENDITL HCVDQIYGVF DEKKKTLFGQ LKKYPEKLII HCKDLRVFHF
CLRYTKEEEV KRIVSGIIHH TQAPKLLKRL FLFSYATAAQ NHTATDPKNH AVMFDTLQDW
CWELERTKGN MKYKAVSVNE GYKVCERLPA YFVVPTPLPE EDVPRFHGHG IPIWCWSCHS
GCALLKMSAL PKEQDDGVLQ IQKNFLDGIY KTIHRPPYEI VKTEDLSSNF LSLQEIQTAY
SKFKQLFLID NSTEFWDTDI KWFSLLESSS WLDIIRRCLK KAIEIIECLE AQNMNVLLLE
ENASDLCCLV SSLVQVMMDP HCRTRFGFQS LVQKEWIVGG HCFLDRCNHL RQSDKEEVPV
FLLFLDCVWQ LVHQHPPAFE FTETYLTVLS DSLYIPIFST FFFNSPHQKD TNMGREGQGA
QSKPLNLLTV WDWSVQFEPK AQTLLKNPLY VEKPKLDKGQ RKGTHFKHQR QLSLPLTQSK
SSPKRGFFRE ETDHLIKNLL GKRISKLINS SEELQDNFRE FYDSWRSKPP NYHGLLLPHI
EGPEIKVWAQ RYLRWIPEAQ ILGGGRVATL SKLLETMEEV QRLQEKIEER HHSQEALQAE
AALLLRTSAR LSSLFPFALL QRHSSKPVLP TSGWKALGDE EDLAKREDEF VDLGDV
//
