ID A0A2Y9Q9Z1_DELLE Unreviewed; 652 AA.
AC A0A2Y9Q9Z1;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=Terpene cyclase/mutase family member {ECO:0000256|RuleBase:RU362003};
DE EC=5.4.99.- {ECO:0000256|RuleBase:RU362003};
GN Name=LSS {ECO:0000313|RefSeq:XP_022452293.1,
GN ECO:0000313|RefSeq:XP_022452296.1, ECO:0000313|RefSeq:XP_022452297.1,
GN ECO:0000313|RefSeq:XP_022452298.1, ECO:0000313|RefSeq:XP_022452300.1};
OS Delphinapterus leucas (Beluga whale).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Monodontidae; Delphinapterus.
OX NCBI_TaxID=9749 {ECO:0000313|Proteomes:UP000248483, ECO:0000313|RefSeq:XP_022452298.1};
RN [1] {ECO:0000313|RefSeq:XP_022452293.1, ECO:0000313|RefSeq:XP_022452296.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022452293.1,
RC ECO:0000313|RefSeq:XP_022452296.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the terpene cyclase/mutase family.
CC {ECO:0000256|ARBA:ARBA00009755, ECO:0000256|RuleBase:RU362003}.
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DR RefSeq; XP_022452293.1; XM_022596585.2.
DR RefSeq; XP_022452296.1; XM_022596588.1.
DR RefSeq; XP_022452297.1; XM_022596589.1.
DR RefSeq; XP_022452298.1; XM_022596590.1.
DR RefSeq; XP_022452300.1; XM_022596592.1.
DR KEGG; dle:111186240; -.
DR Proteomes; UP000248483; Unplaced.
DR GO; GO:0005811; C:lipid droplet; IEA:InterPro.
DR GO; GO:0016866; F:intramolecular transferase activity; IEA:InterPro.
DR GO; GO:0016104; P:triterpenoid biosynthetic process; IEA:InterPro.
DR CDD; cd02892; SQCY_1; 1.
DR Gene3D; 1.50.10.20; -; 2.
DR InterPro; IPR032696; SQ_cyclase_C.
DR InterPro; IPR032697; SQ_cyclase_N.
DR InterPro; IPR018333; Squalene_cyclase.
DR InterPro; IPR002365; Terpene_synthase_CS.
DR InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR NCBIfam; TIGR01787; squalene_cyclas; 1.
DR PANTHER; PTHR11764:SF20; LANOSTEROL SYNTHASE; 1.
DR PANTHER; PTHR11764; TERPENE CYCLASE/MUTASE FAMILY MEMBER; 1.
DR Pfam; PF13243; SQHop_cyclase_C; 1.
DR Pfam; PF13249; SQHop_cyclase_N; 1.
DR SFLD; SFLDG01016; Prenyltransferase_Like_2; 1.
DR SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 2.
DR PROSITE; PS01074; TERPENE_SYNTHASES; 1.
PE 3: Inferred from homology;
KW Isomerase {ECO:0000256|RuleBase:RU362003};
KW Reference proteome {ECO:0000313|Proteomes:UP000248483};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 5..248
FT /note="Squalene cyclase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF13249"
FT DOMAIN 304..640
FT /note="Squalene cyclase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13243"
SQ SEQUENCE 652 AA; 73815 MW; 000390F310228163 CRC64;
MTFYAALQAE DGHWAGDYGG PLFLLPGLLI TCYVAHIPLP AGCREEITRY LRSVQLPDGG
WGLHIEDKST VFGTALNYVS LRILGVGPDD PDLVRARNIL HKKGGAVFIP SWGKFWLAVL
NVYSWEGLNT LFPEMWLFPD WMPAHPSTIW CHCRQVYLPM AYCYGTRLSA EEDPLVQSLR
QELYVEDYGR IDWPAHRDSV APDELYTPHS WLLHVVYAIL NLYERHHSAG LRQRAIQKLS
EHIAADDRFT KYLSIGPISK TINMLACWHR EGPASSAFQE HLSRIPDYLW LGLDGMKVQG
TNGSQIWDTA FAIQALLEAG AQHRPEFSSC LQKAHEYLRV SQVPDNLPDY QKYYRQMSKG
GFSFSTLDCG WIVADCTAEA LKSLLLLQEK CPFVTKHVPR ERLFDAVAVL LSMRNPDGGF
ATYETKRGGH LLELLNPSEI FGDIMIDYTY VECTSAVMQA LKHFHKQFPD HRAGEIRETL
ERGLQFCRQK QRPDGSWEGS WGVCFTYGTY FGLEAFACMG HTYRDGTACA EVSQACDFLL
SRQMADGGWG EDFESCEQRR YVQSARSQIH NTCWALMGLM AVRHPDVAAL ERGVSYLLGK
QLPNGDWPQD NIAGVFNKSC AISYTSYRNI FPIWALGRFS RLHPESALAG HP
//
