ID   A0A2Y9QCM7_DELLE        Unreviewed;       807 AA.
AC   A0A2Y9QCM7;
DT   12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT   12-SEP-2018, sequence version 1.
DT   27-MAR-2024, entry version 19.
DE   SubName: Full=Cas scaffolding protein family member 4 isoform X4 {ECO:0000313|RefSeq:XP_022453238.1};
GN   Name=CASS4 {ECO:0000313|RefSeq:XP_022453238.1};
OS   Delphinapterus leucas (Beluga whale).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC   Monodontidae; Delphinapterus.
OX   NCBI_TaxID=9749 {ECO:0000313|Proteomes:UP000248483, ECO:0000313|RefSeq:XP_022453238.1};
RN   [1] {ECO:0000313|RefSeq:XP_022453238.1}
RP   IDENTIFICATION.
RC   TISSUE=Blood {ECO:0000313|RefSeq:XP_022453238.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell junction, focal adhesion
CC       {ECO:0000256|ARBA:ARBA00004246}.
CC   -!- SIMILARITY: Belongs to the CAS family. {ECO:0000256|ARBA:ARBA00007848}.
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DR   RefSeq; XP_022453238.1; XM_022597530.2.
DR   AlphaFoldDB; A0A2Y9QCM7; -.
DR   Proteomes; UP000248483; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005925; C:focal adhesion; IEA:UniProtKB-SubCell.
DR   GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR   CDD; cd12000; SH3_CASS4; 1.
DR   Gene3D; 1.20.120.230; Alpha-catenin/vinculin-like; 1.
DR   Gene3D; 1.20.120.830; Serine-rich domain; 1.
DR   Gene3D; 2.30.30.40; SH3 Domains; 1.
DR   InterPro; IPR021901; CAS_C.
DR   InterPro; IPR037362; CAS_fam.
DR   InterPro; IPR035744; CASS4_SH3.
DR   InterPro; IPR014928; Serine_rich_dom.
DR   InterPro; IPR038319; Serine_rich_sf.
DR   InterPro; IPR036028; SH3-like_dom_sf.
DR   InterPro; IPR001452; SH3_domain.
DR   PANTHER; PTHR10654; CAS SCAFFOLDING PROTEIN; 1.
DR   PANTHER; PTHR10654:SF19; CAS SCAFFOLDING PROTEIN FAMILY MEMBER 4; 1.
DR   Pfam; PF12026; CAS_C; 1.
DR   Pfam; PF08824; Serine_rich; 1.
DR   Pfam; PF14604; SH3_9; 1.
DR   SMART; SM00326; SH3; 1.
DR   SUPFAM; SSF50044; SH3-domain; 1.
DR   PROSITE; PS50002; SH3; 1.
PE   3: Inferred from homology;
KW   Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW   Cell junction {ECO:0000256|ARBA:ARBA00022949};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Reference proteome {ECO:0000313|Proteomes:UP000248483};
KW   SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW   ProRule:PRU00192}.
FT   DOMAIN          5..67
FT                   /note="SH3"
FT                   /evidence="ECO:0000259|PROSITE:PS50002"
FT   REGION          273..293
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          359..398
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          618..687
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        369..383
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        623..668
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        669..687
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   807 AA;  89994 MW;  A4754B2DDC67D91C CRC64;
     MEKSVKMLLA RALYDNHPDC ADELAFCRGD ILTILEQNVP ESKGWWKCLL HGRQGLAPAN
     RLEILVEAPA DRPCPPFLRG PEDAPTSSQE TYEVPTLLNP SSPGPVYEQM RSWVERPPPP
     TVQVYEVPDP PASARIVCEK TLSFPKQALF TIPRPARTSL PALPCQVYDV PAQSRCLPAL
     KEPGKQQQLY DILPSPQKAA LGPPASQPNG QSVPLMSSIA LRRGSCNTLP SPQKSEWIYD
     TPVSPEKADV RNASLSSFVE KSGHRALPRY MSSFHSPQNS RARTLSPHPQ KNVPMQKKLS
     LPEIPSHSFP PPRDAFPLDE GVSYKVPSSF LISRVEQKNT KLNIYDVPKA VLSVPQAGKE
     LGKADGPSEN SMDHNSSWFS GRAASLSPEP DGLSVSSSDS RASVLSSCSS TSSHSSSSFS
     EESAKELPLD LDLAKETVTA LQHKVDNSVA GLMLFVSRQW RFRDCLEANI HAIRRAADCI
     EESLREFLDF ACGVRGTAWN LTDSKLQAKI RDQLQTISNS YQILLETKES LESCDWSLEV
     LVTNKVQNSL DDLERFVLTA RMLPEDIKRF ASLVIANGRL LFKPNCEKED PMQLTPNAEF
     KLAKSIWLPQ KEIESYQRNA SFQKQRESEH PPELLKKNRT DVCEQELPSL EEKEKPILEQ
     RLDENKDLET QNPSSLSPRP LSQQNPEKKI RLSEHCRLYF GALFKAIGVL HSSLGNGQPP
     EIFIAQSKLV IMVGQKLVDT LCQETQERDV RNEILRGSSH LCSLLKDLAL ATKHAVLQHP
     SPAALQHLQA EAKKLEQHTQ QFRGMLE
//