ID A0A2Y9QCS9_TRIMA Unreviewed; 563 AA.
AC A0A2Y9QCS9;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Bifunctional coenzyme A synthase {ECO:0000313|RefSeq:XP_023581000.1};
GN Name=LOC101353624 {ECO:0000313|RefSeq:XP_023581000.1};
OS Trichechus manatus latirostris (Florida manatee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Sirenia; Trichechidae; Trichechus.
OX NCBI_TaxID=127582 {ECO:0000313|Proteomes:UP000248480, ECO:0000313|RefSeq:XP_023581000.1};
RN [1] {ECO:0000313|RefSeq:XP_023581000.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_004390399.1; XM_004390342.2.
DR RefSeq; XP_023581000.1; XM_023725232.1.
DR AlphaFoldDB; A0A2Y9QCS9; -.
DR STRING; 127582.A0A2Y9QCS9; -.
DR KEGG; tmu:101353624; -.
DR InParanoid; A0A2Y9QCS9; -.
DR OrthoDB; 460288at2759; -.
DR Proteomes; UP000248480; Unplaced.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004140; F:dephospho-CoA kinase activity; IEA:InterPro.
DR GO; GO:0015937; P:coenzyme A biosynthetic process; IEA:InterPro.
DR CDD; cd02022; DPCK; 1.
DR CDD; cd02164; PPAT_CoAS; 1.
DR Gene3D; 3.40.50.620; HUPs; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00376; Dephospho_CoA_kinase; 1.
DR InterPro; IPR004821; Cyt_trans-like.
DR InterPro; IPR001977; Depp_CoAkinase.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR NCBIfam; TIGR00152; dephospho-CoA kinase; 1.
DR PANTHER; PTHR10695:SF64; BIFUNCTIONAL COENZYME A SYNTHASE; 1.
DR PANTHER; PTHR10695; DEPHOSPHO-COA KINASE-RELATED; 1.
DR Pfam; PF01121; CoaE; 1.
DR Pfam; PF01467; CTP_transf_like; 1.
DR SUPFAM; SSF52374; Nucleotidylyl transferase; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51219; DPCK; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000248480};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..17
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 18..563
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5016155302"
FT DOMAIN 196..338
FT /note="Cytidyltransferase-like"
FT /evidence="ECO:0000259|Pfam:PF01467"
FT REGION 163..188
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 164..179
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 563 AA; 62075 MW; 2D2E2E6F4E8A7691 CRC64;
MAVFRSGLLV LTTPLASLTT RLAPILTSAA QLVNHTLYVH LQPGLSLEGP AQPESSPVQA
TFEVLDLITH LYAGASVHGH LDVRVLLTNI RAKSAFLPPQ FSSVQNLAHP PEVVLTDFQT
LDGSQYNPVK QQLERYATSC YSCCPQLASV LLYPEYGSRA VSLEPQDAPS SSTIKPASPV
ARSPKQPVRG YHRGAVGGTF DRLHNAHKVL LSVSCILAQE RLVVGVADKD LLKSKLLPEL
LQSYEVRVER LSEFLVDIKP SLTFDLIPLL DPYGPAGSDP SLEFLVVSEE TYRGGMAVNR
FRLENDLEEL ALYQVQLLKD PNHMENEEDK VSSSNFRQQM LGNLLRPPHK RPELPQNLYV
IGLTGISGSG KSSVAQRLKG LGAYIIDSDH LGHRAYAPGG PAYQPVVEAF GPDILHKDGI
INRKILGSRV FGNKKQLKIL TDIMWPIIAK LAQEEMDLAV AEGKRVCVID AAMLLEAGWQ
NMVHEVWTVV IPETEAVRRI VERDGLSEVA AQSRLQSQMS GQQLVDQSHV VLSTLWEPEV
TQRQVEKAWN LLQKRIPKMP SGP
//
