ID A0A2Y9QCX6_DELLE Unreviewed; 488 AA.
AC A0A2Y9QCX6;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=Fibrinogen beta chain isoform X2 {ECO:0000313|RefSeq:XP_022455400.1};
GN Name=FGB {ECO:0000313|RefSeq:XP_022455400.1};
OS Delphinapterus leucas (Beluga whale).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Monodontidae; Delphinapterus.
OX NCBI_TaxID=9749 {ECO:0000313|Proteomes:UP000248483, ECO:0000313|RefSeq:XP_022455400.1};
RN [1] {ECO:0000313|RefSeq:XP_022455400.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022455400.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBUNIT: Heterohexamer; disulfide linked. Contains 2 sets of 3 non-
CC identical chains (alpha, beta and gamma). The 2 heterotrimers are in
CC head to head conformation with the N-termini in a small central domain.
CC {ECO:0000256|ARBA:ARBA00025974}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
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DR RefSeq; XP_022455400.1; XM_022599692.1.
DR AlphaFoldDB; A0A2Y9QCX6; -.
DR Proteomes; UP000248483; Unplaced.
DR GO; GO:0005577; C:fibrinogen complex; IEA:InterPro.
DR GO; GO:0005102; F:signaling receptor binding; IEA:InterPro.
DR GO; GO:0030168; P:platelet activation; IEA:InterPro.
DR GO; GO:0051258; P:protein polymerization; IEA:InterPro.
DR CDD; cd00087; FReD; 1.
DR Gene3D; 1.20.5.50; -; 2.
DR Gene3D; 3.90.215.10; Gamma Fibrinogen, chain A, domain 1; 1.
DR InterPro; IPR037579; Fibrinogen.
DR InterPro; IPR036056; Fibrinogen-like_C.
DR InterPro; IPR014716; Fibrinogen_a/b/g_C_1.
DR InterPro; IPR002181; Fibrinogen_a/b/g_C_dom.
DR InterPro; IPR012290; Fibrinogen_a/b/g_coil_dom.
DR InterPro; IPR020837; Fibrinogen_CS.
DR NCBIfam; NF040941; GGGWT_bact; 1.
DR PANTHER; PTHR47221; FIBRINOGEN ALPHA CHAIN; 1.
DR PANTHER; PTHR47221:SF2; FIBRINOGEN BETA CHAIN; 1.
DR Pfam; PF08702; Fib_alpha; 1.
DR Pfam; PF00147; Fibrinogen_C; 1.
DR SMART; SM00186; FBG; 1.
DR SMART; SM01212; Fib_alpha; 1.
DR SUPFAM; SSF56496; Fibrinogen C-terminal domain-like; 1.
DR SUPFAM; SSF58010; Fibrinogen coiled-coil and central regions; 1.
DR PROSITE; PS00514; FIBRINOGEN_C_1; 1.
DR PROSITE; PS51406; FIBRINOGEN_C_2; 1.
PE 4: Predicted;
KW Blood coagulation {ECO:0000256|ARBA:ARBA00023084};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Hemostasis {ECO:0000256|ARBA:ARBA00022696};
KW Reference proteome {ECO:0000313|Proteomes:UP000248483};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..29
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 30..488
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5015976087"
FT DOMAIN 229..485
FT /note="Fibrinogen C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51406"
FT REGION 47..89
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 488 AA; 56071 MW; 5C2F51D1ED9D01A1 CRC64;
MVSWNFQKFK TMKHLLLLLL CIFIVKGQAI DDYDEFHLDA RGHRPYDKKR EEAPSLRPVP
PPISGDGYKA RPAKTANRQK KVERKPPDAD GCLHADPDLG VLCPTGCQLQ DTLVKEERPT
RKNVEELITN IESVSQTASS TFQYITLLKN MWKERQKQVK DNENVINEYS SQLEKHQLYI
DETVNSNIPT KLRVLRSILE NLRGKIQKLE SDVSTQMEYC RSPCTVTCNV PVVSGRECEE
IIRNGGETSE MYLIQPDSST QPYRVYCDMK TERGGWTVIQ NRQDGSVDFG RKWDPYKEGF
GNIATNADGK KYCGVPGEYW LGNDKISQLT RLGPTKLFIE MEDWKGDKVT AFYEGFTVQN
EANKYQLSVS KYKGTAGNAL IEGASQLVGE NRTMTIHNSM FFSTYDRDND GWKTTDPRKQ
CSKEDGGGWW YNRCHAANPN GRYYWGGPYT WDMAKHGTDD GVVWMNWQGS WYSMKKMSMK
IRPYFPEQ
//
