ID A0A2Y9QDG5_TRIMA Unreviewed; 156 AA.
AC A0A2Y9QDG5;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=MICOS complex subunit MIC25 {ECO:0000313|RefSeq:XP_023581240.1};
GN Name=LOC101352932 {ECO:0000313|RefSeq:XP_023581240.1};
OS Trichechus manatus latirostris (Florida manatee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Sirenia; Trichechidae; Trichechus.
OX NCBI_TaxID=127582 {ECO:0000313|Proteomes:UP000248480, ECO:0000313|RefSeq:XP_023581240.1};
RN [1] {ECO:0000313|RefSeq:XP_023581240.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Component of the MICOS complex, a large protein complex of
CC the mitochondrial inner membrane that plays crucial roles in the
CC maintenance of crista junctions, inner membrane architecture, and
CC formation of contact sites to the outer membrane.
CC {ECO:0000256|ARBA:ARBA00002689}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004635}; Lipid-
CC anchor {ECO:0000256|ARBA:ARBA00004635}. Mitochondrion inner membrane
CC {ECO:0000256|ARBA:ARBA00034476}; Lipid-anchor
CC {ECO:0000256|ARBA:ARBA00034476}.
CC -!- SIMILARITY: Belongs to the MICOS complex subunit Mic19 family. Metazoan
CC Mic25 subfamily. {ECO:0000256|ARBA:ARBA00034480}.
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DR RefSeq; XP_023581240.1; XM_023725472.1.
DR AlphaFoldDB; A0A2Y9QDG5; -.
DR STRING; 127582.A0A2Y9QDG5; -.
DR KEGG; tmu:101352932; -.
DR InParanoid; A0A2Y9QDG5; -.
DR OrthoDB; 3383910at2759; -.
DR Proteomes; UP000248480; Unplaced.
DR GO; GO:0061617; C:MICOS complex; IEA:InterPro.
DR InterPro; IPR007964; MIC19/MIC25.
DR InterPro; IPR042860; MIC25.
DR PANTHER; PTHR47609; MICOS COMPLEX SUBUNIT MIC25; 1.
DR PANTHER; PTHR47609:SF1; MICOS COMPLEX SUBUNIT MIC25; 1.
DR Pfam; PF05300; MIC19_MIC25; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000248480}.
FT REGION 1..60
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 91..110
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 10..24
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 32..60
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 156 AA; 17663 MW; 0E6637673940C367 CRC64;
MKDSSQPSKV EQPTPPPSTP PPSSAFNSPE GKAKAPEKES KPPRSEKSRA QQPSGAKEDL
LRRYEQEQAI IQDEIFQLAK REREAATKHL NVSLQCEGSS NDREKQKSAQ LARELESIEA
ELRRRDTFCK EQLGRIERKV RLLLGWLFSG PDPKDI
//
