ID A0A2Y9QDJ7_DELLE Unreviewed; 520 AA.
AC A0A2Y9QDJ7;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE RecName: Full=P2X purinoceptor {ECO:0000256|RuleBase:RU000681};
GN Name=P2RX7 {ECO:0000313|RefSeq:XP_022453528.1};
OS Delphinapterus leucas (Beluga whale).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Monodontidae; Delphinapterus.
OX NCBI_TaxID=9749 {ECO:0000313|Proteomes:UP000248483, ECO:0000313|RefSeq:XP_022453528.1};
RN [1] {ECO:0000313|RefSeq:XP_022453528.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022453528.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Receptor for ATP that acts as a ligand-gated ion channel.
CC {ECO:0000256|RuleBase:RU000681}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU000681}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU000681}.
CC -!- SIMILARITY: Belongs to the P2X receptor family.
CC {ECO:0000256|ARBA:ARBA00009848, ECO:0000256|RuleBase:RU000681}.
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DR RefSeq; XP_022453528.1; XM_022597820.2.
DR AlphaFoldDB; A0A2Y9QDJ7; -.
DR Proteomes; UP000248483; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR GO; GO:0098794; C:postsynapse; IEA:GOC.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004931; F:extracellularly ATP-gated monoatomic cation channel activity; IEA:InterPro.
DR GO; GO:0001614; F:purinergic nucleotide receptor activity; IEA:InterPro.
DR GO; GO:0033198; P:response to ATP; IEA:InterPro.
DR Gene3D; 1.10.287.940; atp-gated p2x4 ion channel; 1.
DR Gene3D; 2.60.490.10; atp-gated p2x4 ion channel domain; 1.
DR InterPro; IPR046815; P2RX7_C.
DR InterPro; IPR003050; P2X7_purinoceptor.
DR InterPro; IPR027309; P2X_extracellular_dom_sf.
DR InterPro; IPR001429; P2X_purnocptor.
DR NCBIfam; TIGR00863; P2X; 1.
DR PANTHER; PTHR10125; P2X PURINOCEPTOR; 1.
DR PANTHER; PTHR10125:SF13; P2X PURINOCEPTOR 7; 1.
DR Pfam; PF20478; P2RX7_C; 1.
DR Pfam; PF00864; P2X_receptor; 1.
DR PRINTS; PR01314; P2X7RECEPTOR.
DR PRINTS; PR01307; P2XRECEPTOR.
DR PROSITE; PS01212; P2X_RECEPTOR; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Ion channel {ECO:0000256|RuleBase:RU000681};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU000681}; Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Receptor {ECO:0000256|RuleBase:RU000681};
KW Reference proteome {ECO:0000313|Proteomes:UP000248483};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU000681}.
FT DOMAIN 325..517
FT /note="P2X purinoreceptor 7 intracellular"
FT /evidence="ECO:0000259|Pfam:PF20478"
SQ SEQUENCE 520 AA; 60031 MW; AAA10571341A5B5E CRC64;
MENGLKKVVW NVFDTADYTV PLQGNSFFVM TNFLKIEGQE QGLCPEYPTR RTLCTSDQGC
KKGWMGPKSK GIQTGRCIEY KGKQKTCEVS AWCPVEAAEK APEPALLGSA ENFTVLIKNN
IDFPSHNYTT RNILPDINVT CTFHKTQNPQ CPIFRLGDIF QETGDNFSDV AIQGGIMGIE
IYWDCNLDRW FHHCRPKYNF RRLDNKTAKE SLYPGYSFRY AKYYKENNTE KRTLIKAFGI
RFDILVFGTG GKFDIIQLIV YIGSNLSYFG LGTVFIDFLI NTYSNKCCRS RIYPCCKCCE
PCAVNEYYYR KKCESIVEPK QTLKYVSFVD EPHIRMVNQR LLERSLQDVE GEEVPRPPMD
FTDLSRLPLS LHEPPPIPGQ PEAIQLLSEG ATPRSSDCPN WCQCGNCLPS QLPERQRCLE
ELCCRKKQGA CITTSEPFKK LILSRHVLQF LLHYQEPLLV LDADSTNSQL RHCAYRCYTM
WRFGSQDMAD FAILPSCCRW RIRREFPKRE DQYSGFKSPY
//
