ID   A0A2Y9QE19_DELLE        Unreviewed;       784 AA.
AC   A0A2Y9QE19;
DT   12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT   12-SEP-2018, sequence version 1.
DT   27-MAR-2024, entry version 20.
DE   RecName: Full=Anoctamin {ECO:0000256|RuleBase:RU280814};
GN   Name=ANO4 {ECO:0000313|RefSeq:XP_022455740.1};
OS   Delphinapterus leucas (Beluga whale).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC   Monodontidae; Delphinapterus.
OX   NCBI_TaxID=9749 {ECO:0000313|Proteomes:UP000248483, ECO:0000313|RefSeq:XP_022455740.1};
RN   [1] {ECO:0000313|RefSeq:XP_022455740.1}
RP   IDENTIFICATION.
RC   TISSUE=Blood {ECO:0000313|RefSeq:XP_022455740.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC       Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU280814}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141,
CC       ECO:0000256|RuleBase:RU280814}.
CC   -!- SIMILARITY: Belongs to the anoctamin family.
CC       {ECO:0000256|ARBA:ARBA00009671, ECO:0000256|RuleBase:RU280814}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|RuleBase:RU280814}.
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DR   RefSeq; XP_022455740.1; XM_022600032.1.
DR   AlphaFoldDB; A0A2Y9QE19; -.
DR   Proteomes; UP000248483; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR   InterPro; IPR032394; Anoct_dimer.
DR   InterPro; IPR007632; Anoctamin.
DR   InterPro; IPR049452; Anoctamin_TM.
DR   PANTHER; PTHR12308; ANOCTAMIN; 1.
DR   PANTHER; PTHR12308:SF28; ANOCTAMIN-4; 1.
DR   Pfam; PF16178; Anoct_dimer; 1.
DR   Pfam; PF04547; Anoctamin; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU280814};
KW   Reference proteome {ECO:0000313|Proteomes:UP000248483};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU280814};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU280814}.
FT   TRANSMEM        179..206
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        255..274
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        331..357
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        377..398
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        426..447
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        546..568
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        596..620
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   DOMAIN          28..165
FT                   /note="Anoctamin dimerisation"
FT                   /evidence="ECO:0000259|Pfam:PF16178"
FT   DOMAIN          168..749
FT                   /note="Anoctamin transmembrane"
FT                   /evidence="ECO:0000259|Pfam:PF04547"
FT   COILED          748..782
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   784 AA;  92218 MW;  A4C56F8871315A76 CRC64;
     MGFLLDWLHF CCSSRRKIYY LPRRYKFMSR IDKQISSFRR WLPKKPMRLD KETLPDLEEN
     DCYTAPFSQQ RIHHFIIHNK DTFFNNATRS RIVHHILQRI KYEEGKNKIG LNRLLTNGSY
     EAAFPLHEGS YRSKNSIRTH GAVNHRHLLY ECWASWGVWY KYQPLDLVRR YFGEKIGLYF
     AWLGWYTGML FPAAFIGLFV FLYGVITLDH CQVSKEVCQA TDIIMCPVCD KYCPFMRLSD
     SCVYAKVTHL FDNGATVFFA VFMAVWATVF LEFWKRRRAV IAYDWDLIDW EEEEEEIRPQ
     FEAKYSKKER MNPISGKPEP YQAFADKCSR LIVSASGIFF MICVVIAAVF GIVIYRVVTV
     STFAAFKWAL IRNNSQVATT GTAVCINFCI IMLLNVLYEK VALLLTNLEQ PRTESEWENS
     FTLKMFLFQF VNLNSSTFYI AFFLGRFTGH PGAYLRLINR WRLEECHPSG CLIDLCMQMG
     IIMVLKQTWN NFMELGYPLI QNWWTRRKVR QEHGPERKIS FPQWEKDYNL QPMNAYGLFD
     EYLEMILQFG FTTIFVAAFP LAPLLALLNN IIEIRLDAYK FVTQWRRPLA SRAKDIGIWY
     GILEGIGILS VITNAFVIAI TSDFIPRLVY AYKYGPCAGQ GEAGQKCMVG YVNASLSVFR
     ISDFENRSEP ESDGSEFSGT PLKYCRYRDY RDPPHSLVPY GYTLQFWHVL AARLAFIIVF
     EHLVFCIKHL ISYLIPDLPK DLRDRMRREK YLIQEMMYEA ELERLQKERK ERKKNGKAHH
     NEWP
//