ID A0A2Y9QEL1_DELLE Unreviewed; 365 AA.
AC A0A2Y9QEL1;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=Chemerin-like receptor 1 {ECO:0000256|ARBA:ARBA00026211};
DE AltName: Full=Chemokine-like receptor 1 {ECO:0000256|ARBA:ARBA00030532};
GN Name=CMKLR1 {ECO:0000313|RefSeq:XP_022456050.1,
GN ECO:0000313|RefSeq:XP_022456051.1, ECO:0000313|RefSeq:XP_022456052.1,
GN ECO:0000313|RefSeq:XP_022456053.1, ECO:0000313|RefSeq:XP_022456054.1};
OS Delphinapterus leucas (Beluga whale).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Monodontidae; Delphinapterus.
OX NCBI_TaxID=9749 {ECO:0000313|Proteomes:UP000248483, ECO:0000313|RefSeq:XP_022456051.1};
RN [1] {ECO:0000313|RefSeq:XP_022456050.1, ECO:0000313|RefSeq:XP_022456051.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022456050.1,
RC ECO:0000313|RefSeq:XP_022456051.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000256|RuleBase:RU000688}.
CC -!- SIMILARITY: Belongs to the chemokine-like receptor (CMKLR) family.
CC {ECO:0000256|ARBA:ARBA00025736}.
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DR RefSeq; XP_022456050.1; XM_022600342.2.
DR RefSeq; XP_022456051.1; XM_022600343.2.
DR RefSeq; XP_022456052.1; XM_022600344.2.
DR RefSeq; XP_022456053.1; XM_022600345.2.
DR RefSeq; XP_022456054.1; XM_022600346.2.
DR STRING; 9749.A0A2Y9QEL1; -.
DR Ensembl; ENSDLET00000030786; ENSDLEP00000028016; ENSDLEG00000020161.
DR KEGG; dle:111188134; -.
DR OrthoDB; 5384006at2759; -.
DR Proteomes; UP000248483; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0097004; F:adipokinetic hormone binding; IEA:Ensembl.
DR GO; GO:0097003; F:adipokinetic hormone receptor activity; IEA:Ensembl.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0006935; P:chemotaxis; IEA:Ensembl.
DR GO; GO:0032695; P:negative regulation of interleukin-12 production; IEA:Ensembl.
DR GO; GO:0120162; P:positive regulation of cold-induced thermogenesis; IEA:Ensembl.
DR GO; GO:0045600; P:positive regulation of fat cell differentiation; IEA:Ensembl.
DR GO; GO:0010759; P:positive regulation of macrophage chemotaxis; IEA:Ensembl.
DR GO; GO:0050848; P:regulation of calcium-mediated signaling; IEA:Ensembl.
DR CDD; cd15116; 7tmA_CMKLR1; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR002258; CML1.
DR InterPro; IPR000826; Formyl_rcpt-rel.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR PANTHER; PTHR24225:SF49; CHEMERIN-LIKE RECEPTOR 1; 1.
DR PANTHER; PTHR24225; CHEMOTACTIC RECEPTOR; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR01126; DEZORPHANR.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040,
KW ECO:0000256|RuleBase:RU000688};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Receptor {ECO:0000256|RuleBase:RU000688,
KW ECO:0000313|RefSeq:XP_022456050.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000248483};
KW Transducer {ECO:0000256|RuleBase:RU000688};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000688};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 39..63
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 75..99
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 119..141
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 153..174
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 220..245
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 257..276
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 296..317
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 55..314
FT /note="G-protein coupled receptors family 1 profile"
FT /evidence="ECO:0000259|PROSITE:PS50262"
FT REGION 339..365
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 340..365
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 365 AA; 41219 MW; FAE735513CEE247A CRC64;
MEDEDSNTSL TYEYVYSDDF DPIVVLEELS PLEGRVVRIF LVVVYSIICF LGILGNGLVI
IIATCKMKKT VNTVWFLNLA VADFLFNVFL PIHITYAAMD YHWVFGTAMC KISNFLLIHN
MYTSVFLLTV ISSDRCISVL LPVWSQNHRS VRLAYMACMV IWVLAFFLSS PSLVFRDTAH
VHGKISCFNN FSLSATSSSS WPTHPQVDAV GFGRHVAVTI TRFLCGFLTP MLIITACYVT
IVCKLRRNRL AKTKKPFKVI VTIIITFFLC WCPYHTLYLL ELHHSAMPGS VFSLGVPLAT
AIAIANSCMN PILYVFVGQD FKKFKVALFS RLVHALSEDT GHSSYPSHRS FTKMSSMNER
ETSML
//
