ID   A0A2Y9QHV9_TRIMA        Unreviewed;       374 AA.
AC   A0A2Y9QHV9;
DT   12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT   12-SEP-2018, sequence version 1.
DT   27-MAR-2024, entry version 21.
DE   SubName: Full=HLA class I histocompatibility antigen, B-40 alpha chain-like isoform X1 {ECO:0000313|RefSeq:XP_023581056.1};
GN   Name=LOC101347138 {ECO:0000313|RefSeq:XP_023581056.1};
OS   Trichechus manatus latirostris (Florida manatee).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Afrotheria; Sirenia; Trichechidae; Trichechus.
OX   NCBI_TaxID=127582 {ECO:0000313|Proteomes:UP000248480, ECO:0000313|RefSeq:XP_023581056.1};
RN   [1] {ECO:0000313|RefSeq:XP_023581056.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the MHC class I family.
CC       {ECO:0000256|RuleBase:RU004439}.
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DR   RefSeq; XP_023581056.1; XM_023725288.1.
DR   AlphaFoldDB; A0A2Y9QHV9; -.
DR   STRING; 127582.A0A2Y9QHV9; -.
DR   KEGG; tmu:101347138; -.
DR   InParanoid; A0A2Y9QHV9; -.
DR   OrthoDB; 3840485at2759; -.
DR   Proteomes; UP000248480; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   CDD; cd07698; IgC1_MHC_I_alpha3; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR   Gene3D; 3.30.500.10; MHC class I-like antigen recognition-like; 1.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003006; Ig/MHC_CS.
DR   InterPro; IPR003597; Ig_C1-set.
DR   InterPro; IPR011161; MHC_I-like_Ag-recog.
DR   InterPro; IPR037055; MHC_I-like_Ag-recog_sf.
DR   InterPro; IPR011162; MHC_I/II-like_Ag-recog.
DR   InterPro; IPR001039; MHC_I_a_a1/a2.
DR   PANTHER; PTHR16675:SF250; HISTOCOMPATIBILITY 2, T REGION LOCUS 24; 1.
DR   PANTHER; PTHR16675; MHC CLASS I-RELATED; 1.
DR   Pfam; PF07654; C1-set; 1.
DR   Pfam; PF00129; MHC_I; 1.
DR   PRINTS; PR01638; MHCCLASSI.
DR   SMART; SM00407; IGc1; 1.
DR   SUPFAM; SSF48726; Immunoglobulin; 1.
DR   SUPFAM; SSF54452; MHC antigen-recognition domain; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
DR   PROSITE; PS00290; IG_MHC; 1.
PE   3: Inferred from homology;
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000248480};
KW   Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..26
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           27..374
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5016104992"
FT   TRANSMEM        326..348
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          220..308
FT                   /note="Ig-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50835"
SQ   SEQUENCE   374 AA;  42588 MW;  602FC2EBBED2AA23 CRC64;
     MALFLRIGVR TLLLLLFQGV PEDILARSHS LQYFYTAVSE PGPGVPSFTA SGFVDDQLFI
     HYDSVEMKAK PCAPWLKEDL DYFDDETKIF TSRMKIFHLN LRNVQKYYNQ TWEHSLKKEN
     TEKSAGPHTL QFTYGCELRD DGGTMGHWQY GYDGNDYLSL DMDLLQYTAV SFIARYTKQK
     WEASGNSIKR DKAYLEKECI WWLQRYLECG RERLTRTEPP RTHVTHHPSP DGKVALRCWA
     LGFYPAEITL TWQRDGEDQT QNTELVETRP SGDGTFQKWA AVVVPSGEEQ RYTCHVQHEG
     LSEPFILTWE PPFQPTIPVK KQFPSLGLGA VVLTVVIMGA AVAGFALWRN KSSGTGKPGR
     ESINSSVLKA ALED
//