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Database: UniProt
Entry: A0A2Y9QIK7_DELLE
LinkDB: A0A2Y9QIK7_DELLE
Original site: A0A2Y9QIK7_DELLE 
ID   A0A2Y9QIK7_DELLE        Unreviewed;       419 AA.
AC   A0A2Y9QIK7;
DT   12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT   10-FEB-2021, sequence version 2.
DT   24-JAN-2024, entry version 20.
DE   SubName: Full=LOW QUALITY PROTEIN: neuropeptide FF receptor 2 {ECO:0000313|RefSeq:XP_022455243.2};
GN   Name=NPFFR2 {ECO:0000313|RefSeq:XP_022455243.2};
OS   Delphinapterus leucas (Beluga whale).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC   Monodontidae; Delphinapterus.
OX   NCBI_TaxID=9749 {ECO:0000313|Proteomes:UP000248483, ECO:0000313|RefSeq:XP_022455243.2};
RN   [1] {ECO:0000313|RefSeq:XP_022455243.2}
RP   IDENTIFICATION.
RC   TISSUE=Blood {ECO:0000313|RefSeq:XP_022455243.2};
RG   RefSeq;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- FUNCTION: Receptor for NPAF (A-18-F-amide) and NPFF (F-8-F-amide)
CC       neuropeptides, also known as morphine-modulating peptides. Can also be
CC       activated by a variety of naturally occurring or synthetic FMRF-amide
CC       like ligands. This receptor mediates its action by association with G
CC       proteins that activate a phosphatidylinositol-calcium second messenger
CC       system. {ECO:0000256|ARBA:ARBA00025478}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC       Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000256|RuleBase:RU000688}.
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DR   RefSeq; XP_022455243.2; XM_022599535.2.
DR   STRING; 9749.A0A2Y9QIK7; -.
DR   KEGG; dle:111187666; -.
DR   InParanoid; A0A2Y9QIK7; -.
DR   OrthoDB; 3150248at2759; -.
DR   Proteomes; UP000248483; Unplaced.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008188; F:neuropeptide receptor activity; IEA:InterPro.
DR   GO; GO:0031628; F:opioid receptor binding; IEA:InterPro.
DR   GO; GO:0043408; P:regulation of MAPK cascade; IEA:InterPro.
DR   Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR005395; NPFF_rcpt.
DR   InterPro; IPR005397; NPFF_rcpt_2.
DR   PANTHER; PTHR24241:SF132; NEUROPEPTIDE FF RECEPTOR 2; 1.
DR   PANTHER; PTHR24241; NEUROPEPTIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR; 1.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR01570; NPFFRECEPTOR.
DR   PRINTS; PR01572; NPFFRECEPTR2.
DR   SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR   SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   3: Inferred from homology;
KW   G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040,
KW   ECO:0000256|RuleBase:RU000688};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000256|RuleBase:RU000688,
KW   ECO:0000313|RefSeq:XP_022455243.2};
KW   Reference proteome {ECO:0000313|Proteomes:UP000248483};
KW   Transducer {ECO:0000256|RuleBase:RU000688};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU000688};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        44..70
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        82..103
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        123..141
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        162..184
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        218..238
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        276..297
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        317..336
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          62..333
FT                   /note="G-protein coupled receptors family 1 profile"
FT                   /evidence="ECO:0000259|PROSITE:PS50262"
SQ   SEQUENCE   419 AA;  48150 MW;  25DC6EDD866BE6DC CRC64;
     MSENWESNSS ENWHPIWSVS DTKHDLYADS SITYVNYYLH QPQVAAIFVI SYFLTFFLCM
     VGNTVVCFIV MRNTHMHTVT NLFILNLAVS DLLVGIFCMP ITLLDNIIAG WPFGSTMCKI
     SGLVQGISVA ASVFTLVAIA VDRFQCVVYP FKPKLTIKTA SVIIMIIWIL AIVIMSPSAI
     MLHVQEEKYY RVRLNSQNKT SPVYWCREDW PNREMRKIYT TVLFANIYLA PLSLNVIMYG
     RIGIALSKTT VPPSGKQNQE QWHVVTKKQQ KVIKMLLTVA LLFILSWLPL WTXMMLSHYV
     DLSLNELQVI NTYIYPLAHW LAFGNSSINP IIYGFFNENF RHGFQDAFRL HLCQXREKPK
     EAYTLRAKNN VVINISHLSA QESTIKNPHE DIVLCRKSAE KPIQELMIKN XELTDSNEM
//
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