ID A0A2Y9QIQ8_TRIMA Unreviewed; 421 AA.
AC A0A2Y9QIQ8;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=Ammonium transporter Rh type A {ECO:0000256|ARBA:ARBA00041037};
DE AltName: Full=Erythrocyte membrane glycoprotein Rh50 {ECO:0000256|ARBA:ARBA00042473};
DE AltName: Full=Rhesus blood group family type A glycoprotein {ECO:0000256|ARBA:ARBA00042104};
GN Name=LOC101343571 {ECO:0000313|RefSeq:XP_023581356.1};
OS Trichechus manatus latirostris (Florida manatee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Sirenia; Trichechidae; Trichechus.
OX NCBI_TaxID=127582 {ECO:0000313|Proteomes:UP000248480, ECO:0000313|RefSeq:XP_023581356.1};
RN [1] {ECO:0000313|RefSeq:XP_023581356.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=CO2(out) = CO2(in); Xref=Rhea:RHEA:74891, ChEBI:CHEBI:16526;
CC Evidence={ECO:0000256|ARBA:ARBA00035761};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=NH4(+)(in) = NH4(+)(out); Xref=Rhea:RHEA:28747,
CC ChEBI:CHEBI:28938; Evidence={ECO:0000256|ARBA:ARBA00000309};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=methylamine(out) = methylamine(in); Xref=Rhea:RHEA:74391,
CC ChEBI:CHEBI:59338; Evidence={ECO:0000256|ARBA:ARBA00036281};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the ammonium transporter (TC 2.A.49) family. Rh
CC subfamily. {ECO:0000256|ARBA:ARBA00011036}.
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DR RefSeq; XP_023581356.1; XM_023725588.1.
DR AlphaFoldDB; A0A2Y9QIQ8; -.
DR STRING; 127582.A0A2Y9QIQ8; -.
DR KEGG; tmu:101343571; -.
DR InParanoid; A0A2Y9QIQ8; -.
DR OrthoDB; 5483564at2759; -.
DR Proteomes; UP000248480; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR GO; GO:0008519; F:ammonium transmembrane transporter activity; IEA:InterPro.
DR Gene3D; 1.10.3430.10; Ammonium transporter AmtB like domains; 1.
DR InterPro; IPR029020; Ammonium/urea_transptr.
DR InterPro; IPR024041; NH4_transpt_AmtB-like_dom.
DR InterPro; IPR002229; RhesusRHD.
DR PANTHER; PTHR11730; AMMONIUM TRANSPORTER; 1.
DR PANTHER; PTHR11730:SF32; AMMONIUM TRANSPORTER RH TYPE A; 1.
DR Pfam; PF00909; Ammonium_transp; 1.
DR PRINTS; PR00342; RHESUSRHD.
DR SUPFAM; SSF111352; Ammonium transporter; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000248480};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 7..26
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 46..68
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 80..100
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 172..193
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 205..222
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 242..261
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 298..319
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 331..351
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 363..384
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 17..402
FT /note="Ammonium transporter AmtB-like"
FT /evidence="ECO:0000259|Pfam:PF00909"
SQ SEQUENCE 421 AA; 45777 MW; 0AF68543D1ED6182 CRC64;
MRFKFPLMAI GLEVAMIVLF GVFVQYENVQ NSGQPSNTSS PAVMNSFFRL YPLFQHVNVM
IFVGFGFLMT FLKKYGFSSV GFNFFIAALG LQWGTIIQGL LNDHGEKFHI SIHSLISADF
STTTVLVSFG AVLGKISPIQ VLIMTILEIA VFNGNEYLFA EIFQATDIGG SMVIHAFGAY
FGLAVAGILY RSNQIWEHHN KQSDIHSDLF AMIGTLFLWI FWPSFNSTLA VPEEKQNRAI
INTYFSLAAC VLTSYAFSSL VERRGKLSMA HIQNATLAGG VAVGTCADME INPYGSMIIG
SIAGIVSVIG FKFLTPFFAT TLRIQDTCGV HNLHGLPGIV GGLASIVVIA MGASDVSTTA
MQAATLVTSI GTAVAGGLIT GLILKLPIWE QPPDEDCYDD CVYWEVPTVD DSLSLSRFQP
M
//
