ID A0A2Y9QKG9_DELLE Unreviewed; 792 AA.
AC A0A2Y9QKG9;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Host cell factor 2 {ECO:0000313|RefSeq:XP_022455702.1};
GN Name=HCFC2 {ECO:0000313|RefSeq:XP_022455702.1};
OS Delphinapterus leucas (Beluga whale).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Monodontidae; Delphinapterus.
OX NCBI_TaxID=9749 {ECO:0000313|Proteomes:UP000248483, ECO:0000313|RefSeq:XP_022455702.1};
RN [1] {ECO:0000313|RefSeq:XP_022455702.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022455702.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR RefSeq; XP_022455702.1; XM_022599994.2.
DR AlphaFoldDB; A0A2Y9QKG9; -.
DR STRING; 9749.A0A2Y9QKG9; -.
DR Ensembl; ENSDLET00000022618; ENSDLEP00000020527; ENSDLEG00000014940.
DR KEGG; dle:111187908; -.
DR InParanoid; A0A2Y9QKG9; -.
DR OrthoDB; 5477547at2759; -.
DR Proteomes; UP000248483; Unplaced.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0071339; C:MLL1 complex; IEA:Ensembl.
DR GO; GO:0016604; C:nuclear body; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0048188; C:Set1C/COMPASS complex; IEA:Ensembl.
DR GO; GO:0003712; F:transcription coregulator activity; IEA:Ensembl.
DR GO; GO:0140374; P:antiviral innate immune response; IEA:Ensembl.
DR GO; GO:1902615; P:immune response involved in response to exogenous dsRNA; IEA:Ensembl.
DR GO; GO:0034139; P:regulation of toll-like receptor 3 signaling pathway; IEA:Ensembl.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR CDD; cd00063; FN3; 2.
DR Gene3D; 6.10.250.2590; -; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR Gene3D; 2.120.10.80; Kelch-type beta propeller; 2.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR043536; HCF1/2.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR015915; Kelch-typ_b-propeller.
DR InterPro; IPR006652; Kelch_1.
DR PANTHER; PTHR46003; HOST CELL FACTOR; 1.
DR PANTHER; PTHR46003:SF2; HOST CELL FACTOR 2; 1.
DR Pfam; PF01344; Kelch_1; 1.
DR Pfam; PF13415; Kelch_3; 1.
DR Pfam; PF13854; Kelch_5; 2.
DR SMART; SM00060; FN3; 2.
DR SUPFAM; SSF49265; Fibronectin type III; 1.
DR SUPFAM; SSF117281; Kelch motif; 2.
DR PROSITE; PS50853; FN3; 1.
PE 4: Predicted;
KW Kelch repeat {ECO:0000256|ARBA:ARBA00022441};
KW Reference proteome {ECO:0000313|Proteomes:UP000248483};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 583..675
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT REGION 399..455
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 792 AA; 86780 MW; 0CE526BAC9F5B171 CRC64;
MAAPSLLNWR RVSSFTGPVP RARHGHRAVA IRELMIIFGG GNEGIADELH VYNTVTNQWF
LPAVRGDIPP GCAAHGFVCD GTRILVFGGM VEYGRYSNEL YELQASRWLW KKVKPYPPSS
GLPPCPRLGH SFSLYGNKCY LFGGLANESE DSNNNVPRYL NDFYELELQH GSGVVGWSIP
VTKGIVPSPR ESHTAVIYCR RDSGSPKMYV FGGMCGARLD DLWQLDLETM SWSKPETKGT
VPLPRSLHTA SVIGNKMYIF GGWVPHKGEN IETSPHDCEW RCTSSFSYLN LDTAEWTTLV
SDSQEDKKNS RPRPRAGHCA VAIGTRLYFW SGRDGYKKAL NSQVCCKDLW YLDTEKPPAP
SQVQLIKATT NSFHVKWDEV PTVEGYLLQL NTDLPYQAVS SDSSATPNMQ GVRMDPHRQG
SNSIIPNSIS DTMNSAKSEH TAMKGTSLKN KPELKASTDS NATLHSSLAT NASNHNSCVV
DMLRKNEGPH TSVNIGVLSS CLDLRTVIPE TSVSSTVSNA QTMVTQQTIK TESSSTNGAV
VKDETSLTTF STKSEVDETC ALPATKISRV EAHAAVMPFS KETPSNPVAT MKAGERQWCD
VGIFKNNTAL VSQFYLLPKG KQSISKIGNA DVPDYSLLKK QDLVPGTGYR FRVAAINGCG
IGPFSKISEF KTCIPGFPGA PSAVRISKNV EGIHLSWEPP TSPSGNILEY SAYLAIRTAQ
IQDNPSQLVF MRIYCGLKTS CIVTAGQLAN AHIDYTSRPA IVFRISAKNE KGYGPATQVR
WLQGNNKKAP LN
//
