ID A0A2Y9QLU4_TRIMA Unreviewed; 479 AA.
AC A0A2Y9QLU4;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=GA-binding protein alpha chain isoform X2 {ECO:0000313|RefSeq:XP_023582421.1};
GN Name=LOC101358908 {ECO:0000313|RefSeq:XP_023582421.1};
OS Trichechus manatus latirostris (Florida manatee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Sirenia; Trichechidae; Trichechus.
OX NCBI_TaxID=127582 {ECO:0000313|Proteomes:UP000248480, ECO:0000313|RefSeq:XP_023582421.1};
RN [1] {ECO:0000313|RefSeq:XP_023582421.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU004019}.
CC -!- SIMILARITY: Belongs to the ETS family. {ECO:0000256|ARBA:ARBA00005562,
CC ECO:0000256|RuleBase:RU004019}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_023582421.1; XM_023726653.1.
DR AlphaFoldDB; A0A2Y9QLU4; -.
DR Proteomes; UP000248480; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR CDD; cd08534; SAM_PNT-GABP-alpha; 1.
DR CDD; cd17039; Ubl_ubiquitin_like; 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR000418; Ets_dom.
DR InterPro; IPR046328; ETS_fam.
DR InterPro; IPR024668; GABP_asu_N.
DR InterPro; IPR003118; Pointed_dom.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR016312; TF_GA-bd_asu.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11849; ETS; 1.
DR PANTHER; PTHR11849:SF195; GA-BINDING PROTEIN ALPHA CHAIN; 1.
DR Pfam; PF00178; Ets; 1.
DR Pfam; PF11620; GABP-alpha; 1.
DR Pfam; PF02198; SAM_PNT; 1.
DR PIRSF; PIRSF001703; GABP_alpha; 1.
DR PRINTS; PR00454; ETSDOMAIN.
DR SMART; SM00413; ETS; 1.
DR SMART; SM00251; SAM_PNT; 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS00345; ETS_DOMAIN_1; 1.
DR PROSITE; PS00346; ETS_DOMAIN_2; 1.
DR PROSITE; PS50061; ETS_DOMAIN_3; 1.
DR PROSITE; PS51433; PNT; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU004019};
KW Nucleus {ECO:0000256|RuleBase:RU004019};
KW Reference proteome {ECO:0000313|Proteomes:UP000248480};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 193..276
FT /note="PNT"
FT /evidence="ECO:0000259|PROSITE:PS51433"
FT DOMAIN 345..425
FT /note="ETS"
FT /evidence="ECO:0000259|PROSITE:PS50061"
FT REGION 320..341
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 479 AA; 54164 MW; A6A682800F0BA438 CRC64;
MILPTTETVI PWEIEDWTAL LKTSTMTKRE AEELIEIEID GTEKPECTEE SIVEQTYTPA
ECVSQAIDIN EPIGNLKKLL EPRLQCSLDA HEICLQDIQL DPERSLFDQG VKTDGTVQLS
VQVISYQGIE PKLNILEIVK PAETVEVVID PDAHHAEAEA HLVEEAQVIT LDGTKHITTI
SDETSEQVTR WAAALEGYRK EQERLGIPYD PIQWSTDQVL HWVVWVMKEF SMTDIDLTTL
NISGRELCSL SQEDFFQRVP RGEILWSHLE LLRKYVLASQ EQQMNEIVTI DQPVQIIPAS
VQSAAPTTIK VLNSSTKAAK VQRAPRISGE DRSSPGNRTG NNGQIQLWQF LLELLTDKDA
RDCISWVGDE GEFKLNQPEL VAQKWGQRKN KPTMNYEKLS RALRYYYDGD MICKVQGKRF
VYKFVCDLKT LIGYSAAELN RLVTECEQKK LAKMQLHGIA QPVTAVALAT ASLQAEKDN
//
