ID A0A2Y9QLV2_TRIMA Unreviewed; 1059 AA.
AC A0A2Y9QLV2;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Tensin-3 {ECO:0000313|RefSeq:XP_023580218.1};
GN Name=LOC101345078 {ECO:0000313|RefSeq:XP_023580218.1};
OS Trichechus manatus latirostris (Florida manatee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Sirenia; Trichechidae; Trichechus.
OX NCBI_TaxID=127582 {ECO:0000313|Proteomes:UP000248480, ECO:0000313|RefSeq:XP_023580218.1};
RN [1] {ECO:0000313|RefSeq:XP_023580218.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the PTEN phosphatase protein family.
CC {ECO:0000256|ARBA:ARBA00007881}.
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DR RefSeq; XP_023580218.1; XM_023724450.1.
DR AlphaFoldDB; A0A2Y9QLV2; -.
DR STRING; 127582.A0A2Y9QLV2; -.
DR KEGG; tmu:101345078; -.
DR InParanoid; A0A2Y9QLV2; -.
DR OrthoDB; 3439226at2759; -.
DR Proteomes; UP000248480; Unplaced.
DR GO; GO:0042995; C:cell projection; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR CDD; cd14561; PTP_tensin-3; 1.
DR Gene3D; 2.60.40.1110; -; 1.
DR Gene3D; 3.30.60.20; -; 1.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 1.
DR InterPro; IPR046349; C1-like_sf.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR002219; PE/DAG-bd.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR014020; Tensin_C2-dom.
DR InterPro; IPR029023; Tensin_phosphatase.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR PANTHER; PTHR45734; TENSIN; 1.
DR PANTHER; PTHR45734:SF5; TENSIN-3; 1.
DR Pfam; PF00130; C1_1; 1.
DR Pfam; PF10409; PTEN_C2; 1.
DR SMART; SM00109; C1; 1.
DR SMART; SM01326; PTEN_C2; 1.
DR SMART; SM00404; PTPc_motif; 1.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR SUPFAM; SSF57889; Cysteine-rich domain; 1.
DR PROSITE; PS51182; C2_TENSIN; 1.
DR PROSITE; PS51181; PPASE_TENSIN; 1.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 1.
DR PROSITE; PS50081; ZF_DAG_PE_2; 1.
PE 3: Inferred from homology;
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000248480};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 86..133
FT /note="Phorbol-ester/DAG-type"
FT /evidence="ECO:0000259|PROSITE:PS50081"
FT DOMAIN 164..336
FT /note="Phosphatase tensin-type"
FT /evidence="ECO:0000259|PROSITE:PS51181"
FT DOMAIN 269..325
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT DOMAIN 341..467
FT /note="C2 tensin-type"
FT /evidence="ECO:0000259|PROSITE:PS51182"
FT REGION 148..167
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 524..587
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 687..708
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 721..743
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 886..932
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 545..564
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1059 AA; 115688 MW; 2751AD550A9B2D63 CRC64;
MQKLVEPQGK IDKCINIIRY FITPFPIVNR TSRQKLSKAI EDLNNIIKQL DPIDICRTFD
PIGAAFTFFS SAHGTVTEPE ELATSPHSFK KKAFKKSKVC GVCKQIIDGQ GISCRVCKYS
CHKKCKAKVA VPCCVPVPWE QASGSSSPTA PLCQHRNSRL TAPNPTMEDS QELDLTYITE
RIIAVSFPAS SSEESYLHNL QEVTRMLKSK HGDNYLVLNL SEKRYDLTKL NPKTMDVGWP
DLHAPPLDKM CTICKAQESW LNSDPQHVVV IHCRGGKGRI GMIISSYTHF TNVSASADQA
LDRFAMKKFY DDKVSALMQP SQKRYVQFLS GLLSGSVKMN ASPLFLHFVI LHGIPNFDTG
GVCRPFLKLY QAMQPVYTSG IYTVSPENQS RVCIAIEPAQ LLKGDIMVKC YHKKYRSATR
DIIFRLQFHT GAVQGYGLVF GKEDLDNASK DDRFPDYGKI ELVFSATPEK IQGSEHLHND
HGVIVDYNTA DPLIRWDSYE NLGADGEVLH TQGPVDGSLY AKVRKKSTSD PSIPGGPQAV
LATHSPDHSD HTLSVSSDSG HSTASVRTDK TEERLAPGAK RGLSPQEKAE LDQLLSGFGL
EESENSFKDM TDAQSKYSGT RHVVPAQVHV NGDAKLRDRE TDILDDEMPN HDLHSVDSLG
TLSSSEGQPL AHHGAFTCHK SSQNSLLSDG FGSNTGEDPP GSLGPDLGMS VELLYERSFG
NREPRQPPAL LKKPSVSAQT QTYGQSGYST QTWVRQQQMV AAHQYSFSPD GEARLVSRGT
AENAGLIPAQ PRVPVNPTRG ASSRVVVQRG VGSGPNPPET QLPPPSKAFK PVFANENAMN
GVDLELNPVL SPGSPTLDID QSIEQLNRLI LELDPTFEPL PTHMNTLGSQ TNGAATPDGV
GSRLRASGRL QDPGEGPSRM PGRQGPIGDD PLGGRLRKLS LGQYDNDAGG QPSFSKCNWG
KTTTVDQDPS MASFLNSADT KETVITSYPS DIDVINGRIF SPTKNGSESA PSTPAFPVSP
ETPYVKTPPH YPPFNPLEPK MSSPVSLYKG AHGKKFTHF
//
