ID   A0A2Y9QMD7_TRIMA        Unreviewed;       522 AA.
AC   A0A2Y9QMD7;
DT   12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT   12-SEP-2018, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   SubName: Full=Cadherin-11 {ECO:0000313|RefSeq:XP_023582621.1};
GN   Name=LOC101357943 {ECO:0000313|RefSeq:XP_023582621.1};
OS   Trichechus manatus latirostris (Florida manatee).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Afrotheria; Sirenia; Trichechidae; Trichechus.
OX   NCBI_TaxID=127582 {ECO:0000313|Proteomes:UP000248480, ECO:0000313|RefSeq:XP_023582621.1};
RN   [1] {ECO:0000313|RefSeq:XP_023582621.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- FUNCTION: Cadherins are calcium-dependent cell adhesion proteins.
CC       {ECO:0000256|RuleBase:RU004357}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251,
CC       ECO:0000256|RuleBase:RU003318}; Single-pass type I membrane protein
CC       {ECO:0000256|ARBA:ARBA00004251, ECO:0000256|RuleBase:RU003318}.
CC       Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC       protein {ECO:0000256|ARBA:ARBA00004479}.
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DR   RefSeq; XP_023582621.1; XM_023726853.1.
DR   AlphaFoldDB; A0A2Y9QMD7; -.
DR   STRING; 127582.A0A2Y9QMD7; -.
DR   KEGG; tmu:101357943; -.
DR   InParanoid; A0A2Y9QMD7; -.
DR   OrthoDB; 3667774at2759; -.
DR   Proteomes; UP000248480; Unplaced.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR   CDD; cd11304; Cadherin_repeat; 2.
DR   Gene3D; 2.60.40.60; Cadherins; 3.
DR   Gene3D; 4.10.900.10; TCF3-CBD (Catenin binding domain); 1.
DR   InterPro; IPR039808; Cadherin.
DR   InterPro; IPR002126; Cadherin-like_dom.
DR   InterPro; IPR015919; Cadherin-like_sf.
DR   InterPro; IPR020894; Cadherin_CS.
DR   InterPro; IPR000233; Cadherin_Y-type_LIR.
DR   InterPro; IPR027397; Catenin-bd_sf.
DR   PANTHER; PTHR24027:SF85; CADHERIN-11; 1.
DR   PANTHER; PTHR24027; CADHERIN-23; 1.
DR   Pfam; PF01049; CADH_Y-type_LIR; 1.
DR   Pfam; PF00028; Cadherin; 2.
DR   PRINTS; PR00205; CADHERIN.
DR   SMART; SM00112; CA; 3.
DR   SUPFAM; SSF49313; Cadherin-like; 3.
DR   PROSITE; PS00232; CADHERIN_1; 1.
DR   PROSITE; PS50268; CADHERIN_2; 3.
PE   4: Predicted;
KW   Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW   ProRule:PRU00043};
KW   Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW   ECO:0000256|RuleBase:RU003318};
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000248480};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU003318};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        345..366
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          2..109
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          110..214
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          214..335
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
SQ   SEQUENCE   522 AA;  57507 MW;  86A54B881AF0E036 CRC64;
     MSVSEAAVPG EEVGRVKAKD PDIGENGLVT YNIVDGDGME LFEITTDYET QEGVVKLKKP
     VDFETKRAYS LKVEAANVHI DPKFISNGPF KDTVTVKIAV EDADEPPMFL APSYIHEVQE
     NAAAGTVVGR VHAKDPDAAN SPIRYTIDRH TDLDRFFSIN PEDGFIKTTK PLDREETAWL
     NISVFAAEIH NHHQEAKVPV AIRVLDVNDN APKFAAPYEG FICESDQTKP LSNQPLVTIS
     ADDKDDTANG PRFIFSLPPE IIHNPNFTVR DNRDNTAGVY ARRGGFSRQK QDLYLLPIVI
     SDGGIPPMSS TNTLTIKVCG CDVHGGLLSC NAEAYILNAG LSTGALIAIL ACIIILLVIV
     VLFVTLRRQK KEPLIVFEEE DVRENIITYD DEGGGEEDTE AFDIATLQNP DGINGFIPRK
     DIKPEYQYMP RPGLRPAPNS VDVDDFINTR IQEADNDPTA PPYDSIQIYG YEGRGSVAGS
     LSSLESATTD SDLDYDYLQN WGPRFKKLAD LYGSKDTFDD DS
//