ID A0A2Y9QML9_TRIMA Unreviewed; 8819 AA.
AC A0A2Y9QML9;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Nesprin-1 isoform X3 {ECO:0000313|RefSeq:XP_023584735.1};
GN Name=LOC101350762 {ECO:0000313|RefSeq:XP_023584735.1};
OS Trichechus manatus latirostris (Florida manatee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Sirenia; Trichechidae; Trichechus.
OX NCBI_TaxID=127582 {ECO:0000313|Proteomes:UP000248480, ECO:0000313|RefSeq:XP_023584735.1};
RN [1] {ECO:0000313|RefSeq:XP_023584735.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus outer membrane
CC {ECO:0000256|ARBA:ARBA00004605}; Single-pass type IV membrane protein
CC {ECO:0000256|ARBA:ARBA00004605}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004605}.
CC -!- SIMILARITY: Belongs to the nesprin family.
CC {ECO:0000256|ARBA:ARBA00008619}.
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DR RefSeq; XP_023584735.1; XM_023728967.1.
DR Proteomes; UP000248480; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-UniRule.
DR GO; GO:0005635; C:nuclear envelope; IEA:UniProt.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0051641; P:cellular localization; IEA:UniProt.
DR CDD; cd21241; CH_SYNE1_rpt1; 1.
DR CDD; cd21243; CH_SYNE1_rpt2; 1.
DR CDD; cd00176; SPEC; 11.
DR Gene3D; 1.20.58.60; -; 36.
DR Gene3D; 1.10.418.10; Calponin-like domain; 2.
DR InterPro; IPR001589; Actinin_actin-bd_CS.
DR InterPro; IPR039906; Anc-1/SYNE1/2-like.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR047290; CH_SYNE1_rpt1.
DR InterPro; IPR047291; CH_SYNE1_rpt2.
DR InterPro; IPR012315; KASH.
DR InterPro; IPR018159; Spectrin/alpha-actinin.
DR InterPro; IPR002017; Spectrin_repeat.
DR PANTHER; PTHR21524:SF5; KLARSICHT PROTEIN; 1.
DR PANTHER; PTHR21524; SPECTRIN REPEAT CONTAINING NUCLEAR ENVELOPE PROTEIN 2; 1.
DR Pfam; PF00307; CH; 2.
DR Pfam; PF10541; KASH; 1.
DR Pfam; PF00435; Spectrin; 12.
DR SMART; SM00033; CH; 2.
DR SMART; SM01249; KASH; 1.
DR SMART; SM00150; SPEC; 44.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF46966; Spectrin repeat; 47.
DR PROSITE; PS00019; ACTININ_1; 1.
DR PROSITE; PS00020; ACTININ_2; 1.
DR PROSITE; PS50021; CH; 2.
DR PROSITE; PS51049; KASH; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PROSITE-
KW ProRule:PRU00385}; Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000248480};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|PROSITE-
KW ProRule:PRU00385}; Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT TOPO_DOM 1..8768
FT /note="Cytoplasmic"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00385"
FT TOPO_DOM 8790..8819
FT /note="Perinuclear space"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00385"
FT DOMAIN 26..133
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 177..282
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 8760..8819
FT /note="KASH"
FT /evidence="ECO:0000259|PROSITE:PS51049"
FT REGION 5881..5908
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 6210..6236
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 8266..8302
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 8692..8753
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1327..1354
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1433..1460
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1642..1673
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2000..2054
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2141..2168
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2257..2314
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2362..2396
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3425..3452
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3668..3730
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3774..3823
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 4298..4332
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 4776..4827
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 5527..5554
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 5621..5676
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 5755..5830
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 6250..6277
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 7079..7106
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 7185..7215
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 7834..7878
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 5884..5908
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 8266..8289
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 8819 AA; 1012225 MW; 381064C27C01D761 CRC64;
MATSRTVSRS RDIANVMQRL QDEQEIVQKR TFTKWINSHL AKRKPPMVVD DLFEDMKDGV
KLLALLEVLS GQKLPCEQGR HMKRIHAVAN IGTALKFLEG RKIKLVNINS TDIADGRPSI
VLGLMWTIIL YFQIEEVTSN LPQLQSLSSS MSSVDSTLSA ETASPPSKRK VATKVQGNAK
KALLKWVQHT VTKQAGIEVK DFGRSWRSGV AFHSVIHAIR PELVDLEKVK GRSNRENLEE
AFTIAETELG IPRLLDPEDV DVEKPDEKSV MTYVAQFLKH YPDIHSTAVD GQESDREDRP
VLKEMKVWIE QFERDLTKAQ VTESNLQDKY QSFKHFRVQH EIKRKQIEHL IQPLHRDGKL
SLDQALVKQA WDRVSSRLFD WHIQLDKSLP APLGTIGAWL YRAEVALREE INIQQVHEET
ANTIQRKLEQ HKDLLQNTDA HKRAFHEIYR TRSVNGIPVP PDQLEDMAER FHFVSSTSEL
HLMKMEFLEL KYRLLSLLVL AESKLKSWII KYGRRESVEL LLQNYTLPVK NKDVYEIASP
RQHLPSSCPT SSAYHTGLQL LFCKSFIENS KFFEQYEVTY QILKQTAEMY VKADGSVEEA
ENVMKFMNET TAQWRNLSVE VRSVRSMLEE VISNWDRYGN TVASLQAWLE DAEKMLSQTE
HAKKDFFRNL PHWIQQHTAM NDAGNFLIET CDEMVSLDLK QQLLLLNGRW RELFMEVKQY
ARADEMDRMK KEYADCVKTL SAFATEAQRK LSEPLQVSFM NVKLLIQDLE DIEQRVPVMD
AQYKMITKTA HLITKESPQE EANEMFATMS GLKEQLAKVK ECYSPLLYES QQLLIPLEEL
ETQMTSFYDS LGKINETITI LEHEAQCSAL FKQKHQELLD CQESCKKTLT LIEKGSQSVQ
KFVTLSNVLK HFDQTTLHRQ IADVHVAFQN MVKKTGDWKK HMETNSRLMK KFEESRAELE
KVLQIAQEGL REKGDPEDLL RRHTEFFSQL DQRVLNAFLK ACDELTDILP EQEQQGLQEA
VRKLHKQWKD LQGEAPYHLL HLKIDVEKKR FLASVEECRT ELDRETKLVP QEGSERMIKE
HRIFFSDKGP HHLCEKRLQL IEELCLKLPM RDPVRNTPET CHTALRELRE AIDSTYEKLV
GDPDKWKDYT SRFSEFSSWI SVKETQLKEI KDGTIDTANH GEVKRDVEEI RNGVTEKGET
LSWLKSRLKI LIEVSSETEA QKQGDELAKL SNGFKALITL LSEVEKMLNN FGDRVQYQEI
VKSSLEDLIS GSKEVQEQAE KILDTENLFE AQQLLLHHQQ KTKRISAKKR DVQQQLAQAR
QGEGGLRGRA REELQQLQST LDSVEHSREK QERRIQVTLR KWERFETNKE TVVRYLFQTG
SSHERFLSFS SLESLSSELE QTKEFSKRTE GVAVQAENLV KEASEIPLGP KNKQLIQQQA
ESIKEQVKKL EGTLEEDIKT MEMVKSKWDH FGSNFEALSV WITEKEKELN ALESSSSALD
VQISQIKVTI QEIESKISSI TGLEEEAQSF AQFITTGESA RIKAKLTQVR RYWEELREHA
QCLKAAILGH LSQEQQFEEN LRKIQQSVSE FEAKLADPVK ICSSATETYR VLQEHMDLCQ
ALECLNGTVT AFSASARKVV TRESSVQEAA ALRQQYEAMR SRAKERQTAL ESRLAHWQRL
EKELSTFLTW LERCEAIASS PEAGISADRV KVEGELQLIQ ALQSEVVSQA SLYSNLLQLK
ESLFSVASGE DVKMMKLHLE QLDERWRVLP QIISKRINFL LSVVAEHQQF DELLLSFSVW
IKLFLSELQT TSEISVVDHK AALIRHKDHA AEVESKKGDM KSLQGYLAKL ASLGCADDLH
LLQGKVEDCF QLFEEASQVV ERRQLALCQL AEFLHSHASL SGVLHQLRQT VEATNSMNKK
QSDLLEKGLN DAIQDAKTLE STAIGLDGVL TKAQYHLKSG SSEQRTSCRA MADQLCLELE
RIQNLLGTKL SEADALAVLK KAFLDQKEEL LKSIEDIEER TDKEQLKEPT QQALQQRLRV
FNQLEDELNS HEHELCWLKD KAKQMAQKDT AFAPEVDREI NRLEVTWDDT KKLIHDNQGQ
CCGLIDLLRE YQNLKSVVSK VLENSSSVIG TRTTIKDQED LKWALSKHEA AKNEMNKKQK
EFDNFTSKGK HLLSELKKIH SSDFTLVKTD MESTVDRWLD ISERIEENMD RLRVSLSIWD
DVLAGKDEIE GWSNNSVPQL AESISNLNNS LKTEEFLKEF ESEVKNKALR LEELHSKVND
LKELTKNPET PPDLQFIEAD LRQKLEQAKE ITEVAKGTLK DFTAQTVQVE RFTKDIKTWL
TKLEESLLNC AQTETCEGLK KVKDIQKELQ SQQSNISSTQ ENLNSLCRKY HSAELESLGS
AMTGLIKKYE AVSQLCSKTQ TTLQDSLEKH FNESMQEFQE WFSGVKAAAK ESSDRTGDSK
VLEAKLRDLQ NILDSVSDGQ SKLDAVTQEG QTLYAYLSKQ IVSSIQEHIT KANEEFQAFL
KQCLKDKQSL QDCALELGSF EDQHRKLNLW IHEMEERLST ENLGESKQHI PEKKNQVHKV
EMFLGELLAA RESLDKLSQR GQLLSEEGHG AGKEGRLCSQ LLTSYQNLLR MTKENLRSCQ
VALQEHEALE EALQSMWSWG KDIQDRLACA ESTVGSKDTL EKRLLQIQEI LLLKGEGEVK
LNMAIGKGEQ ALRSSNKEGQ KVIQTQLQAL KDMWANIMSS SVQAQSTLES VISQWNEYLE
RKNQLEQWME SVDQKVEHSL QLQPGLKEKF ALLDHFQSIM SEAEDHAGAL HHLTAKSREL
YEKTEEASFK ETAQQELKTQ FNDIITVAKE KMRKVEEIVK DHLMYLDAVQ EFTDWLHSAK
EELHRWSDMS EDSSATQKKL SKIKELIDSR EIGASRLSRV ESLAPAVKQN TSARGCELMD
AEMQALRADW KQWEDTVFQT RSSLENLASQ MALSEQEFSG QVAQLEEALG QFSALLKTWF
QQLTLLEGKN TDKELVACWH KGKEILDALE KAEPKTEDLK SQLNELCRFS RDLSTYSGKV
SGLIKEYNCL CLQASKGCQN KEQILQQRFR KAFRDFQQWL VNAKITTAKC FDIPQNISEV
STSLQKIQEF LSESENGQHK LNVMLSKGEL LSTLLTEEKA KGIQAKLETA KEDWKNLYSN
LHQKESVLEN LKIQMKDFEV SAEPVQDWLS KTEKMVQESS NRLYDLPAKR REQQKLQSVL
EEINCYEPQL HRLKEKAQQL WEGQAASKSF LHRVSQLSSQ YLALSNVTKE KVSRLDRIVA
EHNQFSLGIK ELQDWMTDTI HMLDSYCHPT SDKSVLDSRM LKLEALLSVK QEKEIQMKII
VSRGESVLQN SSPEGIPAIQ QQLQTMKEMW ASLLSSGIRC KSQLEGALSK WTSYQDDVRQ
FSSWMDSIEA SINESERQCA ELREKTAALG KAKLLNEEVL SHSSLLETIE VKRAGMTEHY
ATQLELQDLQ ERYRAIRERA KEAVTKSEKL VRLHQEYQRE LQAFEIWLGQ EQEKLDRFSI
LEGNAQSHET TLHNLQERQV HCAEGQALLN AVLHTREEVI PSGIPQTEDR ALESLRQDWQ
AYQQRLSDTR TQFNNVVNKL RLMEQKFQEV NEWLKAMEEK VSLRTGCQSS RATKEMQLHQ
MKKWHEEVAA HRDEVEEVGA RAQEILEESH VSSRMGCQAT QLTSRYQALL LQVLEQIKFL
EEEIQSLEES ELSLSSYADW YNSAHKNLKN VATKVDKVDK AMMGKKMKTL EVLLKDMEKG
HNLLKSAREK AERTLKFLED GEAEALRKEI HDHMEQLKEL TSNVRKEHMA LEKGLHLAKE
FSDKHKAQTQ WIAEYQQILH IPEEPKMELY EKKAQLSKYK SLQQMVLSHE PSVKLVREKG
EALLELVQDV TLKDKIDKLQ ADYQDLCHAG KEHVFSLEAK VKDHEDYNSE LQEVEKWLLQ
MSGRLVAPDL METSSLETIT QQLAHHKARM EEIAGFEDRL NNLKIKGDHL ISQCADHLQA
KLKQNVHAHL QGTRDSYSAI CSTAQRVYQS LEHELKKHVS RQDTLQQCQA WLSAVQPDLK
PSPHPPLSRA EAVKQVKHFR ALQEQARTYL DLLCSMCDLS NSSVKTTAKD IQQTEQMIEQ
RLAQAQTLTQ GWEEIKHMEA ELWIYLQDAD QQLQNMKRRH AELELNIAQN MVSQIKDFVK
KVQSKQASVT AIIEKVNKLT KKQESPEHKE ISHLNDRWSD LCLQSNNLCA QREEDLQRTR
DYHDCMKVIE VFLEKFTTDW DNLARSDAES TAVHLEALKQ LALMLQERKY AIEELKDQKQ
KMIEHLNLDD RELVKEQTGH FEQRWFQLED LVKRKIQVSV TNLEELSVVQ SRFKELMEWA
EEQQPSIAEA LKQSPPPDVA RKLLMDHLAI CSELETKRML LKSLMKDADR VMVDLGLNER
QQIQKALSDA QRHVSCLSDL VGQRRKYLNK ALSEKTQFLM AVFQATSQIQ QHERKIMFRE
HICLLPDDVS KQVKTCKSAQ ASLKTYQNEV TGLWAQGRDI MKGATEQEKS EVLGKLQDLQ
SVYDTVLQKC SHRLQELEKN LVSRKHFKED FDKACHWLKQ ADIVTFPEIN LMNESAELHA
QLAKYQHILE QSPEYENLLL NLQRTGQAIL PSLNEVDHSY LSEKLNSLPQ QFNVIVALAK
DKFYKVQEAI LARKEYASLI ELTTQSLSDL EDQFLKMSKV PTNLVVEEAV SLQDGCRALL
GQVVSLGEAV DELNQRKESF QSTGQPWQPN KMLNLVTSYR RLKRQAEQRV SLLEDTTSAY
QEHEKMCQQL ERQLEAVKKE QSKVNEETLP AEEKLKMYHS LAGSLQDSGI LLKRVTMHLE
DLSPHLDPLA YEKAKHKLQS WQEELKVLTS AIGETVTECE SRMVQSIDFQ TEMSRSLDWL
RRVKAELSGP VCLDLNLQDI QEEIRKTQIH QEEVQSSLRI MNALSHKEKE KYTKAKELIS
ANLEHTLAEL SELDGGVQEA LCTRQAALTE TYSQCQQYYQ VFQAANDWLQ DAQEMLQLAG
NGLDVESSEG NLKSHVEFFS TEDQFHSNLE ALQGLVSNLN PLLKPTGKDD LAQKMASLEE
RSRGIIQDSH VQLDLLQRCA AEWQDYQKAR EEVIELMNDA EKKLSEFSVL KTSSSHEAEG
KLSEHKGLVS VVDSFHEKIV ALEEKASQLE KTGNGTSKAT ISRSTTTVWQ RWTRLHAVAQ
DQQKILEDAV DEWKSFNNKV KKATEMIDHL QDKLLESSAE KASKAELVML LENHDTLVLE
LEQQQAALGV LRQQALSVLQ DGAFPAAPGE EPPVMQEITA MQDRCLNMQE KVKNNGKLVK
QELKEREVVE TQINSVKSWV QETKEYLGNP TIEIDAQLEE LQILLTEVTS HRQNIEKMAE
EQKNKYLGFY TILPSELSLQ LAEVALDLGT THDQIQDKVK EVEQSKAMSQ ELSRQIQKIA
KDLTTILTKL KAKTDNLVQA KTEQKVLGEE LDDCNVKLME LDAAVQKFSE ENGQLGKPLV
KKIGKLTELH QQTIKQAENR LSKLSQAASH LEEYNEMLEL ILKWIEKAKV LVGGNITWNS
ASQLREQYIS HQTMLEESEE IHSDLEAMTE KLQYLTSVYC TEKMSQQVAE LGRETEELQQ
MIKIRLQNLQ DAAKDMKKFE AELKNLQTAL EQAQTTLTSP EIGRLSLKEQ LSHRQHLLSE
MESLKPKVQA VQICQSALRI PEDVVTSLPL CHTALRLQDE ASRLQHTAIQ HCNIMQEAVV
QYEQYEQEMK HLQQLIEGAH REIEDKPVAT SNIQELQAQI SRHEELAQKI KGYQEQIASL
NSKCKMLTMK AKHATMLLTV TEVEGLAEGT EDLDGELLPA PSAHPSVVMM TAGRCHTLLS
PVTEESGEEG TNSEISSPPA CRSPSPVANA DASVNQDIAY YQALSAERLQ TEAARIHPSA
PSSQEFYEPG LESSTTAKLD DLQRSWETLK NVISEKQRTL YEALERQQKY QDSLQSISTK
MEAIEMKLNE SLELGKSPES QMAEHQALMD EILMLQDEIN VLQSSLAEEL VSESPESDPA
EQLALQSTLT VLAERMSTIK MKASGKQQLL EEKLNDQLEE QRQEQALQRY RCEADELNHW
LLSTKATLDI TLGTPEEPMD MEAQLVDCQN MLVEIEQKVV ALSELSVHNE NLLLEGKAHT
KDEAEQLAVK LRTLKGSLLE LQRALHDKQL NIQQGTSQEK EESDADLTAS QSPGVQEWLT
QARTTRTYQR QSSLQQQKEL EQELAEQKSL LRSVASRGEE ILSQHSAAET SGAGEKPDVL
SQELGMEGEE SSTEDQMRMK WESLHQEFST KQKLLQNVLE QEQEQVLYSR PNRLLSGVPL
YQGDGQAQAK SAVTSLLDGL NQAFEEVASQ GGGTKRQNMH LEQKLYDGVS ATSTWLDDVE
ERLFVATALL PEETETCLFS QETLAKDIKE MSEEMDKNKN LFSQAFPEKG DNRDVIEDTL
GCLLGRLSLL DSVVNQRCHQ MKERLQQILN FQNDLKVLFT SLADNKYIIL QKLANVFERS
VAEQIEAIQE AEDGLKELDA GIIELKKRGD KLQIEQPSMQ ELSKLQDMYD ELMVTIGSRR
SGLNQNLVFK SQYERALQDL ADLLETGQEK MAGDQKIIVS SKEEVHQLLG KHKEYFQGLE
SHMILTETLF RKIISFAVLK ETQFHEEVMA QASAVLKRAH KRGVELEYIL ETWSQLDEDH
QELSRQLEVV ESSIPSVGLV EEGEDRLIDR ITLYQHLKSS LNEYQPKLYQ VLDDGKRLLI
SISCSDLESQ LNHLGEHWLT NTSKVAKELH RLETILKHWT RYQSESAALI HWLQSAKDRL
EFWSQQSVTV PQELEMVRDH LNAFLEFSKE VDAKSSLKSS VLSTGNQLLR LKKVDTAALR
TELSHIDSQW TELLTHIPVV QEKLHQLQMD RLPSRHAITE VMSWISLMES VIQKDEENIK
NAIGYKAINE YLQKYKGFKI DINCKQLTVD FVNQSVLQIS SQDVESKRSD KTDFAEQLGA
MNKSWQILQG LVTEKIQLLE GLLESWSEYE NNIQSLKTWF EIQEKRLKQQ HQIGDQASVQ
STMKDCQDLE DVIKAKEKEV ETIEQNGLAL IQNKKEDVSG VVKCTLQELT QTWENLDRMA
RQLKILLKSV LDQWSHYRAA FDEINSYLME ARYSLARFRL LTGSLEAVQV QVDNLQSLQD
DLEKQEQSLQ KFGSITNQLL KECHPPVTET LTNTLKEVNM RWNNLLEEIA EQLHSSKALL
QLWQRYKDYS KQCASTVQQQ EGQTNELLKA ATNKDIADDE VATWIQDCND LLKGLGTVKD
SLFVLHELGE QLKQQVDASA ASAIQSDQVS LSQHLCALEQ ALCKQQTTLQ AGVLDYETFA
KSLEGLEAWV VEAEEILQEQ DPSHSSDLAS IQERMEGLKG QMLKFSSMAP DLDHLNELGY
RLPLSDKEIK RMQNLNRHWS LISSQTTERF SKLQSFLLQH QTFLEKCETW MEFLVQTEQK
LAVEISGNYQ HLLEQQRAHE LFQAEMFSRQ QILHSIIIDG QRLLEQGRVD DRDEFNLKLT
LLSNQWQGVI RRAQQRRGII DSQIRQWQRY REMAEKLRKW LVEVSYLPVS GLGSVPVPLQ
QARTLFDEVQ FKEKVFLRQQ GSYILTVEAG KQLLLSADSG AEAALQAELT EIQEKWKSAS
MRLEEQKKQL DFLLKDWEKC EKGIADSLEK LRSFKKKLSQ PLPDHHEELH SEQMRCKELE
NVVGGWTEDL TQLTLLRDTL SAYISTGDIS ILNERMELLQ RQWEELCHQL SLRRQQVSEK
LNEWAVFSEK NKEICEWLTQ MESKVSQNGE ILIEEMIEKL KKDYQEEIAV AQENKIQLQQ
MGERLAKASN ESKASEIEYK LGKVNDRWQH LLDLIAARVK KLKETLVAVQ QLDKNMSSLK
TWLAHIEAEL AKPIVYDSCD SEEIQRKLSE QQELQRDIEK HSTGVASVLN LCEVLLHDCD
ACATDAECDS IQQATRNLDR RWRNICAMSM ERRLKIEETW RLWQKFLDDY SRFEDWLKIS
ERTAAFPSSS GVLYTVAKEE LKKFEAFQRQ VHESLTQLEL INKQYRRLAR ENRTDSACSL
KQMVHDGNQR WDNLQKRVTS ILRRLKHFIG QREEFETARD SILVWLTEMD LQLTNIEHFS
ECDVQAKIKQ LKAFQREISL NHNKIEQIIA QGEQLIEKSE PLDAAVIEEE LDELRRYCQE
VFGRVERYHK KLIRLPLPDD EQDLSDRELE LDDSAALSDL HWHDTSADSV LSPQPSSNPS
LSLAQPLRSE RSGRDTPASV DSIPLEWDHD YDLSRDLESA VSRTLHSEDE ESQEDKDFYL
RGAVGLSGSH GALESRIRQL DKALDDSHFR IQQTENIIRS KTPTGPELDA SYKGYMKLLG
ECSGSIDLVR RLEHQLKEEE ESFPGFVNLD STETQTAGVI DRWELIQAQA LSKELRMKQN
LQKWQQFNSD LNNIWAWLGE TEKELERLQR LELSTDIQTI ELQIKKLKEL QKAVDHRKAI
ILSINLCSPE FTQADCEESR DLQDRLSLMN GRWDRVCSLL EEWRGLLQDA LMQCQDFHEM
SHGLLLMLEN IDRRKNEIVP IDSNLDTEIL QDHHKQLMQI RHDLLESQLK VASLQDMSCQ
LLVNAEGADC LEAKEKVHVI GNRLKLLLKE VSRHIKDLEK LLDMSSSQQD LSSWSSADEL
DTSGSMSPTS GRSTPNQQRT PRGKCSLSQP GPSVNSPHSR STKGGFDSSL SEPQPAQSRR
AFLLRVLRAA LPLQLLLLLL IGLTCLVPMS EEDYSCALSN NFARSFHPML RYTNGPPPL
//
