ID A0A2Y9QND5_TRIMA Unreviewed; 1901 AA.
AC A0A2Y9QND5;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Plexin-D1 {ECO:0000313|RefSeq:XP_023583527.1};
GN Name=LOC101349585 {ECO:0000313|RefSeq:XP_023583527.1};
OS Trichechus manatus latirostris (Florida manatee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Sirenia; Trichechidae; Trichechus.
OX NCBI_TaxID=127582 {ECO:0000313|Proteomes:UP000248480, ECO:0000313|RefSeq:XP_023583527.1};
RN [1] {ECO:0000313|RefSeq:XP_023583527.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the plexin family.
CC {ECO:0000256|ARBA:ARBA00010297}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00352}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_023583527.1; XM_023727759.1.
DR STRING; 127582.A0A2Y9QND5; -.
DR KEGG; tmu:101349585; -.
DR InParanoid; A0A2Y9QND5; -.
DR OrthoDB; 1387371at2759; -.
DR Proteomes; UP000248480; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0017154; F:semaphorin receptor activity; IEA:InterPro.
DR CDD; cd00603; IPT_PCSR; 1.
DR CDD; cd01179; IPT_plexin_repeat2; 1.
DR CDD; cd01181; IPT_plexin_repeat3; 1.
DR CDD; cd12788; RasGAP_plexin_D1; 1.
DR CDD; cd11247; Sema_plexin_D1; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 5.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR002909; IPT_dom.
DR InterPro; IPR031148; Plexin.
DR InterPro; IPR042719; Plexin-D1_Sema.
DR InterPro; IPR013548; Plexin_cytoplasmic_RasGAP_dom.
DR InterPro; IPR046800; Plexin_RBD.
DR InterPro; IPR002165; Plexin_repeat.
DR InterPro; IPR016201; PSI.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR001627; Semap_dom.
DR InterPro; IPR036352; Semap_dom_sf.
DR InterPro; IPR041019; TIG1_plexin.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR22625; PLEXIN; 1.
DR PANTHER; PTHR22625:SF7; PLEXIN-D1; 1.
DR Pfam; PF08337; Plexin_cytopl; 1.
DR Pfam; PF20170; Plexin_RBD; 1.
DR Pfam; PF01437; PSI; 1.
DR Pfam; PF01403; Sema; 1.
DR Pfam; PF01833; TIG; 3.
DR Pfam; PF17960; TIG_plexin; 1.
DR SMART; SM00429; IPT; 3.
DR SMART; SM00423; PSI; 3.
DR SMART; SM00630; Sema; 1.
DR SUPFAM; SSF81296; E set domains; 3.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF103575; Plexin repeat; 1.
DR SUPFAM; SSF101912; Sema domain; 1.
DR PROSITE; PS51004; SEMA; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000248480};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..1901
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5015863059"
FT TRANSMEM 1248..1270
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 12..522
FT /note="Sema"
FT /evidence="ECO:0000259|PROSITE:PS51004"
FT NON_TER 1
FT /evidence="ECO:0000313|RefSeq:XP_023583527.1"
SQ SEQUENCE 1901 AA; 209679 MW; A0B4E491705F9FB8 CRC64;
LRVPPLCPLF LLLLLGTGQA GALEIQRRFP SPTPTNNFAL DGAAGTVYLA AVNRLYQLSG
ANLSLEAEAA VGPVADSPLC HAPQLPQASC EHPRRLTDNY NKILQLDPGQ GLVVVCGSIY
QGFCQLRRRG NISAVAVHFP PAVPPAEPVT VFPSMLNVAA NHPNASTVGL VLPPGAGAGG
SRLLVGATYT GYGSAFFPRN RSLEDHRFEN TPEIAIRSLD ARGDLAKLFT FDLNPSDDNI
LKIKQGAKEQ HKLGFVRAFL HPPDPPPGAQ SYAYLALNSE ARAGDKESQA RSLLARICLP
RGAGGDAKKL TESYIQLGLQ CAGGAGRGDL YSRLVSVFPA RELLFAVFER PPGAPAARAA
PAALCAFRFA DVRAAIRGAR TACFVEPVPD VVAVLDSVVQ GTGPACESKR NIQLQPEQLD
CGAAHLQHPL SVLQPLKATP VFRAPGLTAV AVASVNNYTV VFLGTVSGRL LKINLNESMQ
VVSRRVVTVA YGEPVHHVMQ FDPADPGYLY LMTSHQMARV KVAACDVHST CEDCVGAADA
YCGWCTLETR CTLQQDCANS SRQHFWTSAS EGTSRCPAMT VLPAEIDVHR EYPGMILQLS
GSLPGLSGME MACDYGNNVR TVARVPGPAF SHQIAYCNLL PRDRFPPFPP TQDHVNVEMS
VRVNGRNIVR TNFTIYDCSR IGQVYPHTAC TSCLSTQWPC FWCTQQHACV SNQSRCEASP
NLTTPQDCPQ ILPSPLAPVP TGGSQNILVP LANASFFQGT ALECSFGPEE IFEAMWVNES
TVRCSQVVLH TTQKSQVFPL SLQLKGRPAQ FLDSPDPMTV EVYNCAMGSP DCSQCLGRED
LGHFCVWSDG CRLRGPLQPL PGSCPAPEIH VIEPLSGPLD GGTLLTIRGR NLGRRLRDVA
HGVWIGGVAC EPLADRYTVS EEIVCATGPA PGPFSDVVVV NASKEGRSKE RFSYVLPLVH
SLEPAMGPKA GGTRITIHGS HLDIGSELQV LVNDTELCTD LVRTAASISC TAPSGAMAAL
VPVCVRFERQ GCVRGNLTFR YMRNPVITAI SPRRSLVSGG RTITVAGERF YMVQNVSMAV
HHIGREPTLC KVLNSTLITC PSPGALSNAS APVDFFINGQ VYSDEAAVAE ELLDPEEAQR
GSRFRLDYLP DPQFSTAKRE KWIKHHPGEP LTLVIHKEQD GLGLESHEYR VKIGQVACDI
QIVSDRVIHC SVNESLGAAE GQLPITIQVG NFNQTIATLQ LGGSETAIIV SIVICSVLLL
LSVVALFVFC TKSRRAERYW QKTLLQMEEM ESQIREEIRK GFAELQTDMT DLTKELNRSQ
GIPFLEYKHF VTRTFFPKCS SLYEERYVLP SQTLNSQGGS PVQETHPLLG EWKIPESCRP
NMEEGISLFS SLLNNKHFLI VFVHALEQQK DFAVRDRCSL ASLLTVALHG KLEYYTSIMK
ELLVDLIDAS AAKNPKLMLR RTESVVEKML TNWMSICMYG CLRETVGEPF FLLLCAIKQQ
INKGSIDAIT GKARYTLNEE WLLRENIEAK PRNLNVSFQG CGMDSLSVRA MDTDTLTQVK
EKILEAFCKN VPYSQWPRAE DVDLEWFASS TQSYVLRDLD DTSVVEDGRK KLNTLAHYKI
PEGASLAMSL TDKKDNTLGR VKDLDTEKYF HLVLPTDELA EPKKSHRQSH RKKVLPEIYL
TRLLSTKGTL QKFLDDLFKA ILSIREDKPP LAVKYFFDFL EEQAEKRGIS DPDTLHIWKT
NSLPLRFWVN ILKNPQFVFD IEKTDHIDAC LSVIAQAFID ACSISDLQLG KDSPTNKLLY
AKEIPEYRKI VQRYYKQIHD MTPLSEQEMN AHLAEESRKY QNEFNTNVAM AEIYKYAKRY
RPQIMAALEA NPAARRTQLQ HKFEQVVALM EDNIYECYSE A
//
