ID A0A2Y9QP23_TRIMA Unreviewed; 2261 AA.
AC A0A2Y9QP23;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=ATP-binding cassette sub-family A member 1 isoform X1 {ECO:0000313|RefSeq:XP_004372260.1, ECO:0000313|RefSeq:XP_023583201.1};
GN Name=LOC101352346 {ECO:0000313|RefSeq:XP_004372260.1,
GN ECO:0000313|RefSeq:XP_023583201.1, ECO:0000313|RefSeq:XP_023583202.1,
GN ECO:0000313|RefSeq:XP_023583203.1, ECO:0000313|RefSeq:XP_023583204.1,
GN ECO:0000313|RefSeq:XP_023583205.1, ECO:0000313|RefSeq:XP_023583206.1,
GN ECO:0000313|RefSeq:XP_023583208.1};
OS Trichechus manatus latirostris (Florida manatee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Sirenia; Trichechidae; Trichechus.
OX NCBI_TaxID=127582 {ECO:0000313|Proteomes:UP000248480, ECO:0000313|RefSeq:XP_023583201.1};
RN [1] {ECO:0000313|RefSeq:XP_004372260.1, ECO:0000313|RefSeq:XP_023583201.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR RefSeq; XP_004372260.1; XM_004372203.2.
DR RefSeq; XP_023583201.1; XM_023727433.1.
DR RefSeq; XP_023583202.1; XM_023727434.1.
DR RefSeq; XP_023583203.1; XM_023727435.1.
DR RefSeq; XP_023583204.1; XM_023727436.1.
DR RefSeq; XP_023583205.1; XM_023727437.1.
DR RefSeq; XP_023583206.1; XM_023727438.1.
DR RefSeq; XP_023583208.1; XM_023727440.1.
DR STRING; 127582.A0A2Y9QP23; -.
DR GeneID; 101352346; -.
DR KEGG; tmu:101352346; -.
DR OrthoDB; 6951at2759; -.
DR Proteomes; UP000248480; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR CDD; cd03263; ABC_subfamily_A; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR013525; ABC2_TM.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR026082; ABCA.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR19229; ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A ABCA; 1.
DR PANTHER; PTHR19229:SF34; PHOSPHOLIPID-TRANSPORTING ATPASE ABCA1; 1.
DR Pfam; PF12698; ABC2_membrane_3; 2.
DR Pfam; PF00005; ABC_tran; 2.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840,
KW ECO:0000313|RefSeq:XP_004372260.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000248480};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 25..46
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 640..660
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 680..704
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 716..740
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 752..771
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 777..797
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 818..842
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1347..1368
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1655..1677
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1697..1723
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1735..1754
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1766..1790
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1853..1875
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 899..1131
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT DOMAIN 1912..2144
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT REGION 1286..1310
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2261 AA; 253950 MW; B01955EFA5712A22 CRC64;
MAYWPQLRLL LWKNLTFRRR QTCQLLLEVA WPLFIFLILI SVRLSYPPYE QHECHFPNKA
MPSAGTLPWV QGIICNANNP CFRYPTPGEA PGVVGNFNKS IVSRLFSDAQ RLLLYSQKDT
SMKDIHKVLR TLRQIENSSS NLTLQDFLVH NETFSGFLHH NLSLPRPTVD KMMKADISLH
KVFLHGYQLH LTNLCNGSKL GEVIQLGDQE VSQLCSLPRE KLDAAEQVLR SNMDVLKPIL
AELNSSSPFP SKELAEATKT LLDSLGTLAQ ELFTVRSWSD MRQEVMFLTN VNSSSSPTQI
YQAVSRIVCG HPEGGGLKIK SLNWYEDNNY KALFGGNDTG EDVGTFYDNS TTPYCNDLMK
NLESSPLSRI IWKALKPLLV GKILYTPDTP ATRQVMAEVN KTFQELAVFH DLEGMWEELS
PKIWTFVESS QEMDLIRTLL DSRGSDHFWE ERLDGLGWTA QDIAVFLAKH PEDVEAINGS
VYTWREAFNE TNQAIQTISR FMECVNLNKL EPIATEVRLI NKSMELLDER KFWAGIVFTG
ITSDSVELPH HVKYKIRMDI DNVERTNKIK DGYWDPGPRA DPFEDMRYVW GGFTYLQDVV
EQAIIRVLTG SEKKTGVYVQ QMPYPCYVDD IFLRVMSRSM PLFMTLAWIY SVAVIIKGIV
YEKEARLKET MRIMGLDSGI LWFSWFISSL IPLLVSASLL VVILKLGNLL PYSDPSVVFV
FLSVFAVVTI LQCFLISTFF SRANLAAACG GIIYFMLYLP YVLCVAWQDY VGFTPKIFAS
LLSPVAFGFG CEYFALFEEQ GTGVQWDNLF ESPVEGDGFN FTTSVSMMLF DTFIYGVMTW
YIEAVFPGQY GIPRPWYFPC TKSYWFGEES DEKSHPCSSQ KGISEICMEE EPTHLKLGVS
IQNLVKVYRD GMKVAVDGLR LNFYEGQITS FLGHNGAGKT TTMSILTGLF PPTSGTAYIL
GKDIRSEMST IRQNLGVCPQ HNVLFDMLTV EEHIWFYARL KGLSEKHVKA EMEQMALDVV
LPPSKLKSKT SQLSGGMQRK LSVALAFVGG SKVVILDEPT AGVDPYSRRG IWELLLKYRQ
GRTIILSTHH MDEADILGDR IAIISHGKLC CVGSSLFLKN QLGTGYYLTL VKKDVDSSLS
SCRNSSSTVS YLKKEDSVSQ SSSDAGLGSD HESDTLTIDV SAISNLIRKH VAEARLVEDI
GHELTYVLPY EAAKEGAFVE LFHEIDDRLS DLGISSYGIS ETTLEEIFLK VAEDSGVDAE
TSDGTLPARR KRRAFGDRQS CLRPFTADDA VDPNDSDIDP ESRETDLLSG MDGKGSYQVK
GWKLTQQQFV ALLWKRLLIA RRSRKGFFAQ IVLPAVFVCI ALVFSLIVPP FGKYPSLELQ
PWMYSEQYTF VSNDAPEDIS TQKLLNALTK DPGFGTRCME GNPIPDMPCL VGEEEWITAP
VPQTITDLFQ KGNWTMENPS PACQCSSDKI KKMLPVCPPG AGGLPPPQRR QNTADILQNL
TGRNISDYLV KTYVQIIAKS LKNKIWVNEF RYGGFSLGAS NSQVLPPSEE VNDAIKQVKK
HLKLVKDSSA DRFLSSLGRF MTGLDTKNNV KVWFNNKGWH AISSFLNVIN NAILRANLQK
GENPSKYGIT AFNHPLNLTK QQLSEVALMT TSVDVLVSIC VIFAMSFVPA SFVVFLIQER
VSKAKHLQFI SGVKPVIYWL SNFVWDMCNY VVPATLVIII FICFQQKSYV SSTNLPVLAL
LLLLYGWSIT PLMYPASFVF KIPSTAYVVL TSVNLFIGIN GSVATFVLEL FTNNKLNNIN
DILKSVFLIF PHFCLGRGLI DMVKNQAMAD ALERFGENRF VSPLSWDLVG RNLFAMAVEG
VVFFLITVLI QYRFFIRPRP VNTKLPPLND EDEDVRRERQ RILDGGGQND ILEIKDLTKI
YTRKRKPAVD RICVGIPPGE CFGLLGVNGA GKSSTFKMLT GDTTVTRGDA FLNKNSILSN
IDEVHQSMGY CPQFDAITEL LTGREHVEFF ALLRGVPEKE VGKVGEWAIR KLGLLKYGEK
YAGNYSGGNK RKLSTAMALI GGPPVVFLDE PTTGMDPKAR RFLWNCALSI IKEGRSVVLT
SHSMEECEAL CTRMAIMVNG KFRCLGSVQH LKNRFGDGYT IVVRIAGTNP DLKPVQEFFG
LAFPGSVLKE KHRNMLQYQL PSSLSSLARI FSILSHSKKR LHIEDYSVSQ TTLDQVFVNF
AKDQSDDDHL KDLSLHKNQT VVDVAVLTSF LQDEKVKESY V
//
