ID A0A2Y9QR73_TRIMA Unreviewed; 674 AA.
AC A0A2Y9QR73;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=Anoctamin {ECO:0000256|RuleBase:RU280814};
GN Name=LOC101356762 {ECO:0000313|RefSeq:XP_023581864.1};
OS Trichechus manatus latirostris (Florida manatee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Sirenia; Trichechidae; Trichechus.
OX NCBI_TaxID=127582 {ECO:0000313|Proteomes:UP000248480, ECO:0000313|RefSeq:XP_023581864.1};
RN [1] {ECO:0000313|RefSeq:XP_023581864.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU280814}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU280814}.
CC -!- SIMILARITY: Belongs to the anoctamin family.
CC {ECO:0000256|ARBA:ARBA00009671, ECO:0000256|RuleBase:RU280814}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU280814}.
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DR RefSeq; XP_023581864.1; XM_023726096.1.
DR AlphaFoldDB; A0A2Y9QR73; -.
DR KEGG; tmu:101356762; -.
DR InParanoid; A0A2Y9QR73; -.
DR OrthoDB; 534027at2759; -.
DR Proteomes; UP000248480; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR007632; Anoctamin.
DR InterPro; IPR049452; Anoctamin_TM.
DR PANTHER; PTHR12308; ANOCTAMIN; 1.
DR PANTHER; PTHR12308:SF40; ANOCTAMIN-10; 1.
DR Pfam; PF04547; Anoctamin; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU280814};
KW Reference proteome {ECO:0000313|Proteomes:UP000248480};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU280814};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU280814}.
FT TRANSMEM 208..237
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 243..261
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 314..337
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 357..377
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 400..421
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 501..524
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 591..613
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT DOMAIN 200..626
FT /note="Anoctamin transmembrane"
FT /evidence="ECO:0000259|Pfam:PF04547"
SQ SEQUENCE 674 AA; 77957 MW; 71B19500D62E886A CRC64;
MKVTLSALDT YETSFTPLVV IELAQDVKEE TKEWLKNRII AKKKDGGAQL LFRPLLNKYE
KETLENQNLY LVGASNIRLL LGAEALGLVK ECNDNTMRAF TYGSRQNFKG FDDNNDDFLT
MAECQFIIKH ELENLRARDE KMIPGYPQAK LYPGKSLLRR LITSGVVIQV FPLHDNEALK
KLEDTWYTRL TLKYQPIDNI RGYFGETIAL YFGFLEYFTF ALIPMAVIGL PYYVFVWEDY
DKYVIFASFN LIWSTVILEV WKRGCATMTY RWGTLVMKRH FEEPRPGFHG VLGINPVTGR
EEPLYPSYKR QMRIYLVSLP FVCLCLYFSL YVMMIYFDME DWALGLHENS ESEWTSVLLY
VPSIIYAIVI EIMNRLYRYA AEFLTSWENH RLESAYQNHL ILKVLVFNFL NCFASLFYIA
FVLRDMKLLR QSLATLLITS QILNQIVESF LPYWLQKKHG VQVKRKLQAL KADIDATLYE
QVILEKEMGT YLGTFDDYLE LFLQFGYVSL FSCVYPLAAA FAVLNNFTEV NSDALKMCRV
FKRPFSEPSA NIGVWQLAFE TMSVISVVTN CALIGMSPQV NALFPDSKAD LILIVVAVEH
ALLALKFILA FAIPDKPRHI QMKLARLEFE SLEALKQQVR ETVLNNRYIS LANDRKHNSE
ESLSAFPSAL RLSV
//
