ID A0A2Y9QS50_TRIMA Unreviewed; 1055 AA.
AC A0A2Y9QS50;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Ubiquitin carboxyl-terminal hydrolase 7 {ECO:0000256|ARBA:ARBA00021393};
DE EC=3.4.19.12 {ECO:0000256|ARBA:ARBA00012759};
DE AltName: Full=Ubiquitin thioesterase 7 {ECO:0000256|ARBA:ARBA00031508};
DE AltName: Full=Ubiquitin-specific-processing protease 7 {ECO:0000256|ARBA:ARBA00031500};
GN Name=LOC101353384 {ECO:0000313|RefSeq:XP_004373301.2,
GN ECO:0000313|RefSeq:XP_023584226.1, ECO:0000313|RefSeq:XP_023584227.1};
OS Trichechus manatus latirostris (Florida manatee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Sirenia; Trichechidae; Trichechus.
OX NCBI_TaxID=127582 {ECO:0000313|Proteomes:UP000248480, ECO:0000313|RefSeq:XP_023584226.1};
RN [1] {ECO:0000313|RefSeq:XP_004373301.2, ECO:0000313|RefSeq:XP_023584226.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide
CC and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-
CC residue protein attached to proteins as an intracellular targeting
CC signal).; EC=3.4.19.12; Evidence={ECO:0000256|ARBA:ARBA00000707};
CC -!- SIMILARITY: Belongs to the peptidase C19 family.
CC {ECO:0000256|ARBA:ARBA00009085}.
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DR RefSeq; XP_004373301.2; XM_004373244.3.
DR RefSeq; XP_023584226.1; XM_023728458.1.
DR RefSeq; XP_023584227.1; XM_023728459.1.
DR STRING; 127582.A0A2Y9QS50; -.
DR KEGG; tmu:101353384; -.
DR OrthoDB; 51419at2759; -.
DR Proteomes; UP000248480; Unplaced.
DR GO; GO:0004843; F:cysteine-type deubiquitinase activity; IEA:UniProtKB-EC.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd03772; MATH_HAUSP; 1.
DR CDD; cd02659; peptidase_C19C; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR InterPro; IPR002083; MATH/TRAF_dom.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR001394; Peptidase_C19_UCH.
DR InterPro; IPR008974; TRAF-like.
DR InterPro; IPR024729; USP7_ICP0-binding_dom.
DR InterPro; IPR029346; USP_C.
DR InterPro; IPR018200; USP_CS.
DR InterPro; IPR028889; USP_dom.
DR PANTHER; PTHR24006; UBIQUITIN CARBOXYL-TERMINAL HYDROLASE; 1.
DR PANTHER; PTHR24006:SF644; UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 7; 1.
DR Pfam; PF00917; MATH; 1.
DR Pfam; PF00443; UCH; 1.
DR Pfam; PF14533; USP7_C2; 1.
DR Pfam; PF12436; USP7_ICP0_bdg; 1.
DR SMART; SM00061; MATH; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR SUPFAM; SSF49599; TRAF domain-like; 1.
DR PROSITE; PS50144; MATH; 1.
DR PROSITE; PS00972; USP_1; 1.
DR PROSITE; PS00973; USP_2; 1.
DR PROSITE; PS50235; USP_3; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801,
KW ECO:0000313|RefSeq:XP_004373301.2};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000248480};
KW Thiol protease {ECO:0000256|ARBA:ARBA00022807};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 21..148
FT /note="MATH"
FT /evidence="ECO:0000259|PROSITE:PS50144"
FT DOMAIN 167..474
FT /note="USP"
FT /evidence="ECO:0000259|PROSITE:PS50235"
SQ SEQUENCE 1055 AA; 123146 MW; 9486950A246A2FE8 CRC64;
MSDGHNNTEE DMEDDTSWRS EATFQFTVER FSRLSESVLS PPCFVRNLPW KIMVMPRFYP
DRPHQKSVGF FLQCNAESDS TSWSCHAQAV LKIINYRDDE KSFSRRISHL FFHKENDWGF
SNFMAWSEVT DPEKGFIDDD KVTFEVFVQA DAPHGVAWDS KKHTGYVGLK NQGATCYMNS
LLQTLFFTNQ LRKAVYMMPT EGDDSSKSVP LALQRVFYEL QHSDKPVGTK KLTKSFGWET
LDSFMQHDVQ ELCRVLLDNV ENKMKGTCVE GTIPKLFRGK MVSYIQCKEV DYRSDRREDY
YDIQLSIKGK KNIFESFVDY VAVEQLDGDN KYDAGEHGLQ EAEKGVKFLT LPPVLHLQLM
RFMYDPQTDQ NIKINDRFEF PEQLPLDEFL QKTDPKDPAN YILHAVLVHS GDNHGGHYVV
YLNPKGDGKW CKFDDDVVSR CTKEEAIEHN YGGHDDDLSV RHCTNAYMLV YIRESKLSEV
LQAVTDHDIP QQLVERLQEE KRIEAQKRKE RQEAHLYMQV QIVAEDQFCG HQGNDMYDEE
KVKYTVFKVL KNSSLAEFVQ NLSQTMGFPQ DQIRLWPMQA RSNGTKRPAM LDNEADGNKT
MIELSDNENP WTIFLETVDP ELAASGATLP KFDKDHDVML FLKMYDPKTR SLNYCGHIYT
PISCKIRDLL PVMCDRAGFI QDTSLILYEE VKPNLTERIQ DYDVSLDKAL DELMDGDIIV
FQKDDPENDN SELPTAKEYF RDLYHRVDVI FCDKTIPNDP GFVVTLSNRM NYFQVAKTVA
QRLNTDPMLL QFFKSQGYRD GPGNPLRHNY EGTLRDLLQF FKPRQPKKLY YQQLKMKITD
FENRRSFKCI WLNSQFREEE ITLYPDKHGC VRDLLEECKK AVELGEKASG KLRLLEIVSY
KIIGVHQEDE LLECLSPATS RTFRIEEIPL DQVDIDKENE MLITVAHFHK EVFGTFGIPF
LLRIHQGEHF REVMKRIQSL LDIQEKEFEK FKFAIVMMGR HQYINEDEYE VNLKDFEPQP
GNMSHPRPWL GLDHFNKAPK RSRYTYLEKA IKIHN
//
