ID A0A2Y9QSC3_TRIMA Unreviewed; 1066 AA.
AC A0A2Y9QSC3;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Integrin alpha-6 isoform X3 {ECO:0000313|RefSeq:XP_023586335.1};
GN Name=LOC101342079 {ECO:0000313|RefSeq:XP_023586335.1};
OS Trichechus manatus latirostris (Florida manatee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Sirenia; Trichechidae; Trichechus.
OX NCBI_TaxID=127582 {ECO:0000313|Proteomes:UP000248480, ECO:0000313|RefSeq:XP_023586335.1};
RN [1] {ECO:0000313|RefSeq:XP_023586335.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479,
CC ECO:0000256|RuleBase:RU003762}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU003762}.
CC -!- SIMILARITY: Belongs to the integrin alpha chain family.
CC {ECO:0000256|ARBA:ARBA00008054, ECO:0000256|RuleBase:RU003762}.
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DR RefSeq; XP_023586335.1; XM_023730567.1.
DR AlphaFoldDB; A0A2Y9QSC3; -.
DR Proteomes; UP000248480; Unplaced.
DR GO; GO:0008305; C:integrin complex; IEA:InterPro.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR Gene3D; 1.20.5.930; Bicelle-embedded integrin alpha(iib) transmembrane segment; 1.
DR Gene3D; 2.130.10.130; Integrin alpha, N-terminal; 1.
DR Gene3D; 2.60.40.1460; Integrin domains. Chain A, domain 2; 1.
DR Gene3D; 2.60.40.1510; ntegrin, alpha v. Chain A, domain 3; 1.
DR Gene3D; 2.60.40.1530; ntegrin, alpha v. Chain A, domain 4; 1.
DR InterPro; IPR013517; FG-GAP.
DR InterPro; IPR013519; Int_alpha_beta-p.
DR InterPro; IPR000413; Integrin_alpha.
DR InterPro; IPR013649; Integrin_alpha_Ig-like_1.
DR InterPro; IPR048285; Integrin_alpha_Ig-like_2.
DR InterPro; IPR048286; Integrin_alpha_Ig-like_3.
DR InterPro; IPR028994; Integrin_alpha_N.
DR InterPro; IPR032695; Integrin_dom_sf.
DR PANTHER; PTHR23220; INTEGRIN ALPHA; 1.
DR PANTHER; PTHR23220:SF9; INTEGRIN ALPHA-6; 1.
DR Pfam; PF01839; FG-GAP; 2.
DR Pfam; PF08441; Integrin_A_Ig_1; 1.
DR Pfam; PF20805; Integrin_A_Ig_2; 1.
DR Pfam; PF20806; Integrin_A_Ig_3; 1.
DR PRINTS; PR01185; INTEGRINA.
DR SMART; SM00191; Int_alpha; 5.
DR SUPFAM; SSF69318; Integrin alpha N-terminal domain; 1.
DR SUPFAM; SSF69179; Integrin domains; 3.
DR PROSITE; PS51470; FG_GAP; 4.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW ECO:0000256|RuleBase:RU003762};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Integrin {ECO:0000256|ARBA:ARBA00023037, ECO:0000256|RuleBase:RU003762};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU003762};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU003762};
KW Reference proteome {ECO:0000313|Proteomes:UP000248480};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|RuleBase:RU003762};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003762};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU003762}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT CHAIN 24..1066
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT /id="PRO_5015796806"
FT TRANSMEM 1014..1038
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT REPEAT 30..95
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 301..363
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 364..417
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 418..479
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT DOMAIN 464..624
FT /note="Integrin alpha first immunoglubulin-like"
FT /evidence="ECO:0000259|Pfam:PF08441"
FT DOMAIN 626..792
FT /note="Integrin alpha second immunoglobulin-like"
FT /evidence="ECO:0000259|Pfam:PF20805"
FT DOMAIN 798..1004
FT /note="Integrin alpha third immunoglobulin-like"
FT /evidence="ECO:0000259|Pfam:PF20806"
SQ SEQUENCE 1066 AA; 118294 MW; 4D1137860549160D CRC64;
MAAAGQLWLL YLSAGLLSRL GAAFNLDTRE ENVIQKLGEP GSLFGFSLAM HWQLQPEDKR
LLLVGAPKAK ALPLQRANRT GGLYSCDITS QGPCTRIEFD NNADPSLESK EDQWMGVTVQ
SQGPGGKVVT CAHRYEKRQH VNTKQESRDI FGRCYVLSQN LRIEDDMDGG DWSFCDGRLR
GHEKFGSCQQ GVAATFTKDF HYIVFGAPGT YNWKGIVRVE QKNNSFFDMN IFEDGPYEVG
GESNHDESLV PVPANSYLGF SLDSGKGIVS KDEITFVSGA PRANHSGAVV LLKRDMKSTL
LLPEHIFDGE GLASSFGYDV AVVDLNKDGW QDIVIGAPQY FDRDGEVGGA VYVYINQQGR
WSNVKPIRLN GTKDSMFGIA VKNIGDINQD GYPDIAVGAP YDDNGKVFIY HGSANGVNTK
PTQVLEGKSP YFGYSIAGNM DLDRNSYPDV AVGSLSDSVT VFRSRPVINV QKTITVTPDK
IDLSKKMSCA APSGICLKVK ACFEYTAKPT GYNPSIVIVG TLEAEKERRK SGLSSRVQFR
NQGSEPKYTR QLTLSRQKQK VCMDETLWLQ ENIRDKLRPI PITASVEIQE SSSRRRVNSL
PEVLPILNSN EPKTVHTDVH FLKEGCGNDN ICNSNLKLEY KFCTREGNQD KFSYLPISQK
GIPELVLKDQ KDIALEITVT NSPSNPRNPT NDGDDAHEAK LIATFPDTLT YSAYRELRSF
PEKQLSCVAN QNGSQADCEL GNPFKRNSSV TFYLILSTTE VTFDTTDLDI NLKLETTSNQ
DNLASITAKA KVVIELLLSV SGVAKPSQVY FGGTVVGEQA MKSEDEVGSL IEYEFRVINL
GKPLKNLGTA TLNIQWPKEI SNGKWLLYLV KVESKGLEKI ACEPPSEINF LKLKESHNSR
KKREIAEKQT DDSRKFSLFA ERKYQTLNCS VNVNCVNIRC PLRGLDSKAS VILHSRLWNS
TFLEEYSKMN YLDVLMRASI DVTATAENIK LPNAGTQVRV TVFPSKTAAQ YSGVPWWIIL
VAILAGILML GLLVFLLWKC IGLLLIPYRG ESDCKEHDTN SRLYSI
//
