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Database: UniProt
Entry: A0A2Y9QWX6_TRIMA
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ID   A0A2Y9QWX6_TRIMA        Unreviewed;       320 AA.
AC   A0A2Y9QWX6;
DT   12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT   12-SEP-2018, sequence version 1.
DT   24-JAN-2024, entry version 22.
DE   RecName: Full=N-acetylneuraminate lyase {ECO:0000256|ARBA:ARBA00039936};
DE            EC=4.1.3.3 {ECO:0000256|ARBA:ARBA00012911};
DE   AltName: Full=N-acetylneuraminate pyruvate-lyase {ECO:0000256|ARBA:ARBA00043127};
DE   AltName: Full=N-acetylneuraminic acid aldolase {ECO:0000256|ARBA:ARBA00041211};
DE   AltName: Full=Sialate lyase {ECO:0000256|ARBA:ARBA00042346};
DE   AltName: Full=Sialate-pyruvate lyase {ECO:0000256|ARBA:ARBA00041376};
DE   AltName: Full=Sialic acid aldolase {ECO:0000256|ARBA:ARBA00041560};
DE   AltName: Full=Sialic acid lyase {ECO:0000256|ARBA:ARBA00042218};
GN   Name=LOC101359533 {ECO:0000313|RefSeq:XP_004372953.1,
GN   ECO:0000313|RefSeq:XP_023583868.1, ECO:0000313|RefSeq:XP_023583869.1,
GN   ECO:0000313|RefSeq:XP_023583870.1, ECO:0000313|RefSeq:XP_023583871.1,
GN   ECO:0000313|RefSeq:XP_023583872.1, ECO:0000313|RefSeq:XP_023583873.1,
GN   ECO:0000313|RefSeq:XP_023583874.1};
OS   Trichechus manatus latirostris (Florida manatee).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Afrotheria; Sirenia; Trichechidae; Trichechus.
OX   NCBI_TaxID=127582 {ECO:0000313|Proteomes:UP000248480, ECO:0000313|RefSeq:XP_023583874.1};
RN   [1] {ECO:0000313|RefSeq:XP_004372953.1, ECO:0000313|RefSeq:XP_023583868.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=aceneuramate = N-acetyl-D-mannosamine + pyruvate;
CC         Xref=Rhea:RHEA:23296, ChEBI:CHEBI:15361, ChEBI:CHEBI:17122,
CC         ChEBI:CHEBI:173083; EC=4.1.3.3;
CC         Evidence={ECO:0000256|ARBA:ARBA00024547};
CC   -!- PATHWAY: Amino-sugar metabolism; N-acetylneuraminate degradation.
CC       {ECO:0000256|ARBA:ARBA00004878}.
CC   -!- SUBUNIT: Homotetramer. {ECO:0000256|ARBA:ARBA00011881}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC   -!- SIMILARITY: Belongs to the DapA family. NanA subfamily.
CC       {ECO:0000256|ARBA:ARBA00006324}.
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DR   RefSeq; XP_004372953.1; XM_004372896.2.
DR   RefSeq; XP_023583868.1; XM_023728100.1.
DR   RefSeq; XP_023583869.1; XM_023728101.1.
DR   RefSeq; XP_023583870.1; XM_023728102.1.
DR   RefSeq; XP_023583871.1; XM_023728103.1.
DR   RefSeq; XP_023583872.1; XM_023728104.1.
DR   RefSeq; XP_023583873.1; XM_023728105.1.
DR   RefSeq; XP_023583874.1; XM_023728106.1.
DR   GeneID; 101359533; -.
DR   KEGG; tmu:101359533; -.
DR   OrthoDB; 101328at2759; -.
DR   Proteomes; UP000248480; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0008747; F:N-acetylneuraminate lyase activity; IEA:UniProtKB-EC.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR   CDD; cd00954; NAL; 1.
DR   Gene3D; 3.20.20.70; Aldolase class I; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR002220; DapA-like.
DR   InterPro; IPR005264; NanA.
DR   InterPro; IPR020624; Schiff_base-form_aldolases_CS.
DR   PANTHER; PTHR12128; DIHYDRODIPICOLINATE SYNTHASE; 1.
DR   PANTHER; PTHR12128:SF21; N-ACETYLNEURAMINATE LYASE; 1.
DR   Pfam; PF00701; DHDPS; 1.
DR   PIRSF; PIRSF001365; DHDPS; 1.
DR   PRINTS; PR00146; DHPICSNTHASE.
DR   SMART; SM01130; DHDPS; 1.
DR   SUPFAM; SSF51569; Aldolase; 1.
DR   PROSITE; PS00665; DHDPS_1; 1.
PE   3: Inferred from homology;
KW   Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|PIRNR:PIRNR001365};
KW   Reference proteome {ECO:0000313|Proteomes:UP000248480};
KW   Schiff base {ECO:0000256|ARBA:ARBA00023270}.
FT   ACT_SITE        143
FT                   /note="Proton donor/acceptor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR001365-1"
FT   ACT_SITE        173
FT                   /note="Schiff-base intermediate with substrate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR001365-1"
FT   BINDING         52
FT                   /ligand="pyruvate"
FT                   /ligand_id="ChEBI:CHEBI:15361"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR001365-2"
FT   BINDING         216
FT                   /ligand="pyruvate"
FT                   /ligand_id="ChEBI:CHEBI:15361"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR001365-2"
SQ   SEQUENCE   320 AA;  35190 MW;  E1E43934882C6AB1 CRC64;
     MASSKKKLEG LVAATITPMT ENGEINFSVI GQYVDYLVEE QGVKSIFVNG TTGEGLSLSI
     SERRQVAEEW VTKGRNKLDQ VVIHVGALSL KESQELAKHA AEIGADGIAV IAPFFLKPWN
     KDVLINFLKE VAAAAPALPF YYYHIPALTG IKIRAEELLD GIQDKIPTFQ GLKFSDTDLL
     DFGQCVDQNQ QRQFAFLFGV DEQLLSALVM GATGAVGSTY NYLGKKANQM LEAFEQKDFS
     SALNYQFCIQ RFINFVVKLG FGVSQTKAIM TLVSGIPMGP PRLPLQKASR EFTDNAEAKL
     KSLDFLPFTG LKDRNLEACS
//
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