ID A0A2Y9QWX6_TRIMA Unreviewed; 320 AA.
AC A0A2Y9QWX6;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE RecName: Full=N-acetylneuraminate lyase {ECO:0000256|ARBA:ARBA00039936};
DE EC=4.1.3.3 {ECO:0000256|ARBA:ARBA00012911};
DE AltName: Full=N-acetylneuraminate pyruvate-lyase {ECO:0000256|ARBA:ARBA00043127};
DE AltName: Full=N-acetylneuraminic acid aldolase {ECO:0000256|ARBA:ARBA00041211};
DE AltName: Full=Sialate lyase {ECO:0000256|ARBA:ARBA00042346};
DE AltName: Full=Sialate-pyruvate lyase {ECO:0000256|ARBA:ARBA00041376};
DE AltName: Full=Sialic acid aldolase {ECO:0000256|ARBA:ARBA00041560};
DE AltName: Full=Sialic acid lyase {ECO:0000256|ARBA:ARBA00042218};
GN Name=LOC101359533 {ECO:0000313|RefSeq:XP_004372953.1,
GN ECO:0000313|RefSeq:XP_023583868.1, ECO:0000313|RefSeq:XP_023583869.1,
GN ECO:0000313|RefSeq:XP_023583870.1, ECO:0000313|RefSeq:XP_023583871.1,
GN ECO:0000313|RefSeq:XP_023583872.1, ECO:0000313|RefSeq:XP_023583873.1,
GN ECO:0000313|RefSeq:XP_023583874.1};
OS Trichechus manatus latirostris (Florida manatee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Sirenia; Trichechidae; Trichechus.
OX NCBI_TaxID=127582 {ECO:0000313|Proteomes:UP000248480, ECO:0000313|RefSeq:XP_023583874.1};
RN [1] {ECO:0000313|RefSeq:XP_004372953.1, ECO:0000313|RefSeq:XP_023583868.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=aceneuramate = N-acetyl-D-mannosamine + pyruvate;
CC Xref=Rhea:RHEA:23296, ChEBI:CHEBI:15361, ChEBI:CHEBI:17122,
CC ChEBI:CHEBI:173083; EC=4.1.3.3;
CC Evidence={ECO:0000256|ARBA:ARBA00024547};
CC -!- PATHWAY: Amino-sugar metabolism; N-acetylneuraminate degradation.
CC {ECO:0000256|ARBA:ARBA00004878}.
CC -!- SUBUNIT: Homotetramer. {ECO:0000256|ARBA:ARBA00011881}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the DapA family. NanA subfamily.
CC {ECO:0000256|ARBA:ARBA00006324}.
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DR RefSeq; XP_004372953.1; XM_004372896.2.
DR RefSeq; XP_023583868.1; XM_023728100.1.
DR RefSeq; XP_023583869.1; XM_023728101.1.
DR RefSeq; XP_023583870.1; XM_023728102.1.
DR RefSeq; XP_023583871.1; XM_023728103.1.
DR RefSeq; XP_023583872.1; XM_023728104.1.
DR RefSeq; XP_023583873.1; XM_023728105.1.
DR RefSeq; XP_023583874.1; XM_023728106.1.
DR GeneID; 101359533; -.
DR KEGG; tmu:101359533; -.
DR OrthoDB; 101328at2759; -.
DR Proteomes; UP000248480; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0008747; F:N-acetylneuraminate lyase activity; IEA:UniProtKB-EC.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR CDD; cd00954; NAL; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR002220; DapA-like.
DR InterPro; IPR005264; NanA.
DR InterPro; IPR020624; Schiff_base-form_aldolases_CS.
DR PANTHER; PTHR12128; DIHYDRODIPICOLINATE SYNTHASE; 1.
DR PANTHER; PTHR12128:SF21; N-ACETYLNEURAMINATE LYASE; 1.
DR Pfam; PF00701; DHDPS; 1.
DR PIRSF; PIRSF001365; DHDPS; 1.
DR PRINTS; PR00146; DHPICSNTHASE.
DR SMART; SM01130; DHDPS; 1.
DR SUPFAM; SSF51569; Aldolase; 1.
DR PROSITE; PS00665; DHDPS_1; 1.
PE 3: Inferred from homology;
KW Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|PIRNR:PIRNR001365};
KW Reference proteome {ECO:0000313|Proteomes:UP000248480};
KW Schiff base {ECO:0000256|ARBA:ARBA00023270}.
FT ACT_SITE 143
FT /note="Proton donor/acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR001365-1"
FT ACT_SITE 173
FT /note="Schiff-base intermediate with substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR001365-1"
FT BINDING 52
FT /ligand="pyruvate"
FT /ligand_id="ChEBI:CHEBI:15361"
FT /evidence="ECO:0000256|PIRSR:PIRSR001365-2"
FT BINDING 216
FT /ligand="pyruvate"
FT /ligand_id="ChEBI:CHEBI:15361"
FT /evidence="ECO:0000256|PIRSR:PIRSR001365-2"
SQ SEQUENCE 320 AA; 35190 MW; E1E43934882C6AB1 CRC64;
MASSKKKLEG LVAATITPMT ENGEINFSVI GQYVDYLVEE QGVKSIFVNG TTGEGLSLSI
SERRQVAEEW VTKGRNKLDQ VVIHVGALSL KESQELAKHA AEIGADGIAV IAPFFLKPWN
KDVLINFLKE VAAAAPALPF YYYHIPALTG IKIRAEELLD GIQDKIPTFQ GLKFSDTDLL
DFGQCVDQNQ QRQFAFLFGV DEQLLSALVM GATGAVGSTY NYLGKKANQM LEAFEQKDFS
SALNYQFCIQ RFINFVVKLG FGVSQTKAIM TLVSGIPMGP PRLPLQKASR EFTDNAEAKL
KSLDFLPFTG LKDRNLEACS
//