ID A0A2Y9R092_TRIMA Unreviewed; 740 AA.
AC A0A2Y9R092;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 24-JAN-2024, entry version 19.
DE SubName: Full=Adhesion G protein-coupled receptor E4-like isoform X4 {ECO:0000313|RefSeq:XP_023589020.1};
GN Name=LOC101345977 {ECO:0000313|RefSeq:XP_023589020.1};
OS Trichechus manatus latirostris (Florida manatee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Sirenia; Trichechidae; Trichechus.
OX NCBI_TaxID=127582 {ECO:0000313|Proteomes:UP000248480, ECO:0000313|RefSeq:XP_023589020.1};
RN [1] {ECO:0000313|RefSeq:XP_023589020.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR RefSeq; XP_023589020.1; XM_023733252.1.
DR AlphaFoldDB; A0A2Y9R092; -.
DR Proteomes; UP000248480; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:InterPro.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR Gene3D; 2.60.220.50; -; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR046338; GAIN_dom_sf.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR InterPro; IPR001740; GPCR_2_EMR1-like_rcpt.
DR InterPro; IPR000832; GPCR_2_secretin-like.
DR InterPro; IPR017983; GPCR_2_secretin-like_CS.
DR InterPro; IPR000203; GPS.
DR PANTHER; PTHR12011:SF433; ADHESION G PROTEIN-COUPLED RECEPTOR E4P-RELATED; 1.
DR PANTHER; PTHR12011; ADHESION G-PROTEIN COUPLED RECEPTOR; 1.
DR Pfam; PF00002; 7tm_2; 1.
DR Pfam; PF01825; GPS; 1.
DR PRINTS; PR01128; EMR1HORMONER.
DR PRINTS; PR00249; GPCRSECRETIN.
DR SMART; SM00303; GPS; 1.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS00650; G_PROTEIN_RECEP_F2_2; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
DR PROSITE; PS50221; GPS; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000313|RefSeq:XP_023589020.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000248480};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 416..440
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 452..471
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 483..507
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 527..546
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 566..591
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 612..631
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 643..666
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 417..667
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
FT REGION 692..740
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 692..713
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 714..740
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 740 AA; 82534 MW; 9984520A1B7EFF9F CRC64;
MKGVKYPNSA NMDLKDINLE GEQRFVFGSC QPPLEDSGKI TDPNSASMYL TVIPEKGKPR
AVIVSCKPLL EANWKIFAPT CAPMNFILIY QESVPYTLIM NCQHPKEINR NITALTSAPT
DFTVFTDTPE VKPHSVVVTS QPPLETNGRT TASTYAPMDV TVITAEGKQH AVTVRRNPAQ
KDNGKINKNN SKEVQTSVDI WRNGGRARAW KQLNNIWNHG TKKDIAQMAT QLLQEVVVTT
WNEIFASPGK HENPELGIAY ETNRCNETSK RIILEAGNNT MDIDCTHAFK ETTRGQRDFA
LIVYRTLGDI VNGSFFSGRK GLQDVKLNSF VVSGTNDSEK KIYLSKPVFL TLKHTQPVGA
RTKHLCASWE GSKEGGRWST KGCSHMGSND SHTTCQCFHL PSFAVLMALT PKADSALAVI
TCVGLSLSLL CLLLAAFTFL LCRSIQNTST SLHLQLSFCL FLAHLLFLVG IDKTEPEVLC
SVIAGALHYL YLASFTWMLL EALQLFLTVR NFKVSNYTSE GRFKKNFMYP FGYGIPAVIV
AVSAGVGHKN YGTNTHCWLK LDKSFIWSFM GPVATIILIN LVFYFIILCI LKSKVSSLSK
EVSTVRNTRV MTFKTIAQLF ILSCSWILGF FMVEAVGTTA GLVIAYIFII INVLQGVLLF
VLYCLLNHQV RMEYKKWFSG MRKGFEMEST ELSHSTTHTK MEEPGKSSEF VQRRDTKNTT
FAQPEPPTHL ATVSSLKTEK
//