ID A0A2Y9R0G6_TRIMA Unreviewed; 2890 AA.
AC A0A2Y9R0G6;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Nucleosome-remodeling factor subunit BPTF isoform X8 {ECO:0000313|RefSeq:XP_023585088.1};
GN Name=LOC101350452 {ECO:0000313|RefSeq:XP_023585088.1};
OS Trichechus manatus latirostris (Florida manatee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Sirenia; Trichechidae; Trichechus.
OX NCBI_TaxID=127582 {ECO:0000313|Proteomes:UP000248480, ECO:0000313|RefSeq:XP_023585088.1};
RN [1] {ECO:0000313|RefSeq:XP_023585088.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_023585088.1; XM_023729320.1.
DR Proteomes; UP000248480; Unplaced.
DR GO; GO:0016589; C:NURF complex; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR CDD; cd05509; Bromo_gcn5_like; 1.
DR CDD; cd15559; PHD1_BPTF; 1.
DR CDD; cd15560; PHD2_3_BPTF; 2.
DR Gene3D; 1.20.920.10; Bromodomain-like; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 3.
DR InterPro; IPR038028; BPTF.
DR InterPro; IPR001487; Bromodomain.
DR InterPro; IPR036427; Bromodomain-like_sf.
DR InterPro; IPR018359; Bromodomain_CS.
DR InterPro; IPR018501; DDT_dom.
DR InterPro; IPR028941; WHIM2_dom.
DR InterPro; IPR019786; Zinc_finger_PHD-type_CS.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR001965; Znf_PHD.
DR InterPro; IPR019787; Znf_PHD-finger.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR45975; NUCLEOSOME-REMODELING FACTOR SUBUNIT BPTF; 1.
DR PANTHER; PTHR45975:SF2; NUCLEOSOME-REMODELING FACTOR SUBUNIT BPTF; 1.
DR Pfam; PF00439; Bromodomain; 1.
DR Pfam; PF02791; DDT; 1.
DR Pfam; PF00628; PHD; 3.
DR Pfam; PF15613; WSD; 1.
DR PRINTS; PR00503; BROMODOMAIN.
DR SMART; SM00297; BROMO; 1.
DR SMART; SM00571; DDT; 1.
DR SMART; SM00249; PHD; 3.
DR SUPFAM; SSF47370; Bromodomain; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 3.
DR PROSITE; PS00633; BROMODOMAIN_1; 1.
DR PROSITE; PS50014; BROMODOMAIN_2; 1.
DR PROSITE; PS50827; DDT; 1.
DR PROSITE; PS01359; ZF_PHD_1; 1.
DR PROSITE; PS50016; ZF_PHD_2; 3.
PE 4: Predicted;
KW Bromodomain {ECO:0000256|ARBA:ARBA00023117, ECO:0000256|PROSITE-
KW ProRule:PRU00035};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000248480};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00146}.
FT DOMAIN 101..161
FT /note="DDT"
FT /evidence="ECO:0000259|PROSITE:PS50827"
FT DOMAIN 251..298
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 2653..2704
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 2711..2762
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 2788..2858
FT /note="Bromo"
FT /evidence="ECO:0000259|PROSITE:PS50014"
FT REGION 1..93
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 425..637
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 924..964
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1132..1169
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1230..1256
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1268..1315
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1368..1396
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1470..1557
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1831..1860
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2171..2206
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2283..2435
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2509..2528
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2592..2644
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1880..1907
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1..48
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 52..66
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 75..90
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 425..462
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 463..477
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 490..528
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 546..587
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 589..622
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1230..1252
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1268..1309
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1368..1384
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1480..1511
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1525..1547
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2283..2325
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2326..2356
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2357..2435
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2509..2525
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2592..2610
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2620..2644
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2890 AA; 321641 MW; 04AC72282DA37068 CRC64;
MVSEEEEEED GDAEETQDSE DEEEDEMEED EDDSDYPEEM EDDDDDASYC TESSFRSHST
YSSTPGRRKP RVHRPRSPIL EEKDIPPLDF PKSSEDLMVP NEHIMNVIAI YEVLRNFGTV
LRLSPFRFED FCAALVSQEQ CTLMAEMHVV LLKAVLREED TSNTTFGPAD LKDSVNSTLY
FIDGMTWPEV LRVYCESDKE YHHVLPYQEA EDYPYGPVEN KIKVLQFLVD QFLTTNIARE
ELMSEGVIQY DDHCRVCHKL GDLLCCETCS AVYHLECVKP PLEEVPEDEW QCEVCVAHKV
PGVTDCVAEI QKNKPYIRHE PIGYDRSRRK YWFLNRRLII EEDTENENEK KIWYYSTKVQ
LAELIDCLDK DYWEAELCKI LEEMREEIHR HMDITEDLTN KARGSNKSFL AAANEEILES
IRAKKGDIDT DRSPEEIEKD KNETENTDSK DSEKSREEFE DQSLEKDNDD QTPDDDTEQG
KYEEPTEVGD KGNSVSTNLG DNTTNAASEE SSPSERRSPV GYLSETHDSS NMAEKKVASE
LPQDVPEEPN KTSDNSNTSA TTTSIQPNLE NSNSSSELNS SPSESAKAAD DPENGERESH
TPVSSQEEIG DYKSEKSNGE RSESPGAGRG GSGSTRIITR LRNPDSKLSQ LKSQQVAAAA
HEANKLFKEG KEVLVVNSQG EISRLSTKKE VVMKGNINNY FKLGQEGKYR VYHNQYSTNS
FALNKHQHRE DHDKRRHLAH KFCLTPAGEF KWNGSVHGSK VLTISTLRLT ITQLENNIPS
SFLHPNWASH RANWIKAVQM CSKPREFALA LAILECAVKP VVMLPIWRES LGHTRLHRMT
SIEREEKEKV KKKEKKQEEE ETMQQATWVK YTFPVKHQVW KQKGEEYRVT GYGGWSWISK
THVYRFVPKL PGNTNVNYRK SLEETKNNMD ENMDESDKRK SPRSPKKVKV ELNSEKGEVK
DSDAAKGIDQ SEMDISKITE KDQDVKEVLD SDNDKSFKEE PMEIDDDVKL ESHMNCQEIS
QVDVVNVSEG FHLRTSYKKK TKSSKLDGLL ERRIKQFTLE EKQRLEKMKL ESGIKGIGKT
STNSLKSLSE SPVITKVKEE CDLLRQVQSR NASNDKSENL IQGCSQSDSS VLGISDSNHT
TNKLYPKDQG LDDVPIQSPE ANCQKQNSVV NDIDKRLSEP TSKGQEPSNI KTKGTDLLMD
DSKLASTNEI GTLIYKNKKP LLQEDNDTIV SPSESSLLPS LPRSSSDREN PSLSKAVDFE
GKLGCDSEYN STLENSSDTM SIQDSSEEDM IVQSSSESIS EQFTAQEQGI EDSEPLKREF
VSDKSPGKCG DRLQANVSEA NGEKLSQEPK LEERPVNKCI DQINLRNITD KKNNENRESE
KKGQKASTFQ INGKDNKPKA YLKGECLKEN SESKVVSGDV EPKVNKINKV IPENDTKSLT
IRESTVKPFM NGDVIMEDFN EKNNLGTRSC LLGSSDAEGD YQDSLETLPS TKESESAQTT
TPPPSHPERS SVNQVEEMET ETSEVKKVTP SPITSGEESN LSNDFIDENG LPINRDENIN
GEAKRKTVIT EVTTMTSTVA TESKTVIKVA KGDKQTVVSS TENCAKSTVT TTTTVTKLST
PSTGSSVDII SVKEQSRTVV TTTVTDSLTT AGGTLVTSMT VSKEYSTRDK VKLMKFSRPK
KTRSGTALPS YRKFITKSSK KSIFVLPNDD LKKLARKGGI REVPYFNYNA KPALDIWPYP
SPRPTFGITW RYRLQTVKSL AGVSLMLRLL WASLRWDDMA AKAPPGGGTT RTETSETKIT
TTEIIKRRDV GPYGIRSEYC IRKIICPIGV PEAPKETPTP QRKGLRSSAL RPKRPETPKQ
TGPVIIETWV AEEELELWEI RAFAERVEKE KAQAVEQQAK VSEQKKAEDF KAQVEVQLKQ
QLLAAQQKRL EQQKPTVIAA STTSPTNSTT STVSPAQKVM VAPISGSVAP GAKMVLTTKV
GSPATVTFQQ NKNFHQTFAT WVKQGQSNSA TSTAATSATT IASTGQTFQI TGNPVTMAGK
VITKLPLPAN SKIVAVNVPA TQGGVVQVQQ KVLGIIPSST GTSQQTFTSF QPRTATVTIR
PNTSGSGGTT STSQVITGPQ IRPGMTVIRT PLQQSTLGKA IIRTPVMVQP GTPQQVVTQI
IRGQPVSTAV SAPNAVSSAP GQKALTSSAP TASLQSPTSQ PPRPQQGQVK LTMAQLTQLT
QGQGGNQGLT VVIQGQGQTT GQLQLIPQGV TVLPGPGQQL MQAAMPNGTV QRFLFTPLAT
TATTASTTST TVSTTAAGTS EQRQSKLSPQ TQVQQAKTLP PAQSSSVSPP ETPPPTAQPS
AQPQPPAQPP APAQPEVQTQ PEVQTQTTVS SHVPSEAQPI QTQSSKPQAA VQCQPQSNVQ
GQSPVRVQSP PQTRIRPSTP SQVSPGQQPQ VQTTASQPIA IQPHTSLQIP SQGQPQSQPQ
VVMKQNAVIE HLKQKKTMTP AEREENQRMI VCNQVMKYIL DKIDKEEKQA AKKRKREESV
EQKRSKQNAT KLSALLFKHK EQLKAEILKK RALLDKDLQI EVQEELKKDL KLKKEKDLAQ
AAAVAAALPV TAAPPAPPPS PPPALQPPGL LSTPTIPAAS QKRKREEDKD STSKSKKKKM
ISTTSKETKK DTKLYCICKT PYDESKFYIG CDLCTNWYHG ECVGITEKEA KKMDVYICND
CKRAQEGSSE ELYCICRTPY DESQFYIGCD RCQNWYHGRC VGILQSEAEL IDEYVCPQCQ
STEDAMTVLT PLTEKDYEGL KRVLRSLQAH KMAWPFLEPV DPNDAPDYYG VIKEPMDLAT
MEERVQRRYY ERLTEFVADM TKIFDNCRYY NPSDSPFYQC AEVLESFFVQ KLKGFKASRS
HNNKLQSTAS
//
