ID A0A2Y9R0U3_TRIMA Unreviewed; 806 AA.
AC A0A2Y9R0U3;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=F-BAR domain only protein 2 {ECO:0000256|ARBA:ARBA00018998};
GN Name=LOC101340369 {ECO:0000313|RefSeq:XP_023585218.1};
OS Trichechus manatus latirostris (Florida manatee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Sirenia; Trichechidae; Trichechus.
OX NCBI_TaxID=127582 {ECO:0000313|Proteomes:UP000248480, ECO:0000313|RefSeq:XP_023585218.1};
RN [1] {ECO:0000313|RefSeq:XP_023585218.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane, clathrin-coated pit
CC {ECO:0000256|ARBA:ARBA00004283}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004283}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004283}.
CC -!- SIMILARITY: Belongs to the FCHO family.
CC {ECO:0000256|ARBA:ARBA00011064}.
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DR RefSeq; XP_023585218.1; XM_023729450.1.
DR AlphaFoldDB; A0A2Y9R0U3; -.
DR STRING; 127582.A0A2Y9R0U3; -.
DR KEGG; tmu:101340369; -.
DR InParanoid; A0A2Y9R0U3; -.
DR OrthoDB; 2996449at2759; -.
DR Proteomes; UP000248480; Unplaced.
DR GO; GO:0005905; C:clathrin-coated pit; IEA:UniProtKB-SubCell.
DR CDD; cd07673; F-BAR_FCHO2; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 2.60.40.1170; Mu homology domain, subdomain B; 2.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR031160; F_BAR.
DR InterPro; IPR001060; FCH_dom.
DR InterPro; IPR030122; FCHo2_F-BAR.
DR InterPro; IPR028565; MHD.
DR InterPro; IPR018808; Muniscin_C.
DR PANTHER; PTHR23065:SF8; F-BAR DOMAIN ONLY PROTEIN 2; 1.
DR PANTHER; PTHR23065; PROLINE-SERINE-THREONINE PHOSPHATASE INTERACTING PROTEIN 1; 1.
DR Pfam; PF00611; FCH; 1.
DR Pfam; PF10291; muHD; 1.
DR SMART; SM00055; FCH; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR PROSITE; PS51741; F_BAR; 1.
DR PROSITE; PS51072; MHD; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|PROSITE-ProRule:PRU01077};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000248480}.
FT DOMAIN 34..278
FT /note="F-BAR"
FT /evidence="ECO:0000259|PROSITE:PS51741"
FT DOMAIN 546..805
FT /note="MHD"
FT /evidence="ECO:0000259|PROSITE:PS51072"
FT REGION 329..380
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 420..448
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 466..536
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 466..483
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 806 AA; 88908 MW; 2093A47E4F448E41 CRC64;
MYGAMETYKG IGIQVWLPSM QKLKNIRVGR NLVTTWSTKG EKNSGFDVLY HNMKHGQIST
KELADFVRER AAIEEAYSRS MTKLAKSASN YSQLGTFAAM WDVFKTSTEK LANCHLDLVR
KLQELIKEIQ KYGEEQVKSH KKTKEEVAGT LEAVQTIQSI TQALQKSKEN YNAKCVEQER
LKKEGATQRE VEKAAVKSKK ATDTYKIYVE KYALAKADFE QKMTETAQKF QDIEETHLIR
MKEIIESLSN AIKEIHLQIG QVHEEFLNNM ANTTVESLIQ KYVESKGTGK ERPGLIEFEE
CDPASAVEGI KPRKRKTFAL PGIIKKEKDA ESVECPDADS LNIPDVDEEG YSIKPEANQN
DTKENHFYSS SDSDSEDEEP KKYRIEIKPM HPNNSHHTMA SLDELKVSIG NIMLSPAISR
HSPVQMNRNS SSEELTKSKL SAPSNEKGTN DLLAWDPLFG PSLDSSSSAS LTSSLSARPT
TPLSVGTIVP PPRPASRPKL TSGKLSGINE IPRPFSPPVT SNTSPPPAAP LARAESSSSI
SSSASLSAAN TPTVEIPNFR CIVKITGDMT ISFPSGIIKV FTSNPSPAVL CFRVKNISRL
EQILPNAQLV FSDPSQCDSN TKDFWMNMQA VTVYLKKLSE QNPAASYYNI DVLKYQVSSN
GIQSTPLNLA TYWKCSAGTT DLRVDYKYNP EAMVAPSVLS NIQVVVPVDG GVTNMQSLPP
AIWNAEQMKA FWKLSGISEK SENGGSGSLR AKFDLSEGPS KPTTLAVQFL SEGSTLSGVD
IELVGTGYRL SLVKKRFATG RYLADC
//
