ID A0A2Y9R225_TRIMA Unreviewed; 497 AA.
AC A0A2Y9R225;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE RecName: Full=Importin subunit alpha {ECO:0000256|PIRNR:PIRNR005673};
GN Name=LOC101352720 {ECO:0000313|RefSeq:XP_023589619.1,
GN ECO:0000313|RefSeq:XP_023589620.1};
OS Trichechus manatus latirostris (Florida manatee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Sirenia; Trichechidae; Trichechus.
OX NCBI_TaxID=127582 {ECO:0000313|Proteomes:UP000248480, ECO:0000313|RefSeq:XP_023589620.1};
RN [1] {ECO:0000313|RefSeq:XP_023589619.1, ECO:0000313|RefSeq:XP_023589620.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Functions in nuclear protein import.
CC {ECO:0000256|PIRNR:PIRNR005673}.
CC -!- SIMILARITY: Belongs to the importin alpha family.
CC {ECO:0000256|ARBA:ARBA00010394, ECO:0000256|PIRNR:PIRNR005673}.
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DR RefSeq; XP_023589619.1; XM_023733851.1.
DR RefSeq; XP_023589620.1; XM_023733852.1.
DR Proteomes; UP000248480; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0061608; F:nuclear import signal receptor activity; IEA:InterPro.
DR GO; GO:0006606; P:protein import into nucleus; IEA:InterPro.
DR Gene3D; 1.20.5.690; Importin-alpha, importin-beta-binding domain; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR032413; Arm_3.
DR InterPro; IPR000225; Armadillo.
DR InterPro; IPR002652; Importin-a_IBB.
DR InterPro; IPR036975; Importin-a_IBB_sf.
DR InterPro; IPR024931; Importin_alpha.
DR PANTHER; PTHR23316; IMPORTIN ALPHA; 1.
DR PANTHER; PTHR23316:SF7; IMPORTIN SUBUNIT ALPHA-3; 1.
DR Pfam; PF00514; Arm; 8.
DR Pfam; PF16186; Arm_3; 1.
DR Pfam; PF01749; IBB; 1.
DR PIRSF; PIRSF005673; Importin_alpha; 1.
DR SMART; SM00185; ARM; 8.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR PROSITE; PS50176; ARM_REPEAT; 3.
DR PROSITE; PS51214; IBB; 1.
PE 3: Inferred from homology;
KW Protein transport {ECO:0000256|ARBA:ARBA00022927,
KW ECO:0000256|PIRNR:PIRNR005673};
KW Reference proteome {ECO:0000313|Proteomes:UP000248480};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|PIRNR:PIRNR005673}.
FT DOMAIN 1..34
FT /note="IBB"
FT /evidence="ECO:0000259|PROSITE:PS51214"
FT REPEAT 90..134
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT REPEAT 133..160
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT REPEAT 260..298
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
SQ SEQUENCE 497 AA; 55041 MW; 6C5D91857BD27F2B CRC64;
MRRQRNEVVV ELRKNKRDEH LLKRRNVPHE DICEDSDIDG DYRVQNTSLE AIVQNASSDN
QGIQLSAVQA ARKLLSSDRN PPIDDLIKSG ILPILVHCLE RDDNPSLQFE AAWALTNIAS
GTSEQTQAVV QSNAVPLFLR LLHSPHQNVC EQAVWALGNI IGDGPQCRDY VISLGVVKPL
LSFISPSIPI TFLRNVTWVM VNLCRHKDPP PPMETIQEIL PALCVLIHHT DVNILVDTVW
ALSYLTDAGN EQIQMVIDSG IVPHLVPLLS HQEVKVQTAA LRAVGNIVTG TDEQTQVVLN
CDALSHFPAL LTHPKEKINK EAVWFLSNIT AGNQQQVQAV IDANLVPMII HLLDKGDFGT
QKEAAWAISN LTISGRKDQV AYLIQQNVIP PFCNLLTVKD AQVVQVVLDG LSNILKMAED
EAETIANLIE ECGGLEKIEQ LQNHENEDIY KLAYEIIDQF FSSDDIDEDP SLVPEAIQGG
TFGFNSSANV PTEGFQF
//